TY - JOUR
T1 - Conjugated Estrogen for Platelet Dysfunction Associated with Liver Disease
AU - Perez, Edith A.
AU - Tanaka, Michael
AU - Gandara, David R.
PY - 1988/6/9
Y1 - 1988/6/9
N2 - To the Editor: Livio et al. (Sept. 18, 1986, issue)1 demonstrated the beneficial effect of conjugated-estrogen therapy in reversing platelet dysfunction in patients with uremia. The authors concluded that conjugated estrogens are an adequate alternative to cryoprecipitate or desmopressin in this clinical setting. The mechanism of action remains unclear, since in contrast to cryoprecipitate and desmopressin, estrogen does not appear to increase the circulating level or change the multimeric structure of von Willebrand factor. In a fashion similar to that of patients with uremia, patients with liver disease may have a hemostatic defect related to platelet dysfunction. Desmopressin has been.
AB - To the Editor: Livio et al. (Sept. 18, 1986, issue)1 demonstrated the beneficial effect of conjugated-estrogen therapy in reversing platelet dysfunction in patients with uremia. The authors concluded that conjugated estrogens are an adequate alternative to cryoprecipitate or desmopressin in this clinical setting. The mechanism of action remains unclear, since in contrast to cryoprecipitate and desmopressin, estrogen does not appear to increase the circulating level or change the multimeric structure of von Willebrand factor. In a fashion similar to that of patients with uremia, patients with liver disease may have a hemostatic defect related to platelet dysfunction. Desmopressin has been.
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U2 - 10.1056/NEJM198806093182317
DO - 10.1056/NEJM198806093182317
M3 - Letter
C2 - 2835682
AN - SCOPUS:0023927491
SN - 0028-4793
VL - 318
SP - 1543
JO - New England Journal of Medicine
JF - New England Journal of Medicine
IS - 23
ER -