TY - JOUR
T1 - Congress on women's health trudy bush lecture 2014
T2 - New insights into sex hormones and cardiovascular disease
AU - Miller, Virginia M.
N1 - Publisher Copyright:
© Copyright 2014, Mary Ann Liebert, Inc. 2014.
PY - 2014/12/1
Y1 - 2014/12/1
N2 - Many basic, mechanistic studies of how sex steroids alter vascular function proceeded from Dr. Bush's seminal epidemiologic observations that noncontraceptive use of estrogen reduced all-cause and cardiovascular mortality. However, translating findings from these basic science studies into clinical trials and clinical guidelines has been controversial. This commentary reviews the development of sex steroid vascular research, identifies mechanisms by which sex steroids affect vascular function, reviews findings from recent clinical hormone trials, and identifies challenges and the need for continued funding of such investigations.
AB - Many basic, mechanistic studies of how sex steroids alter vascular function proceeded from Dr. Bush's seminal epidemiologic observations that noncontraceptive use of estrogen reduced all-cause and cardiovascular mortality. However, translating findings from these basic science studies into clinical trials and clinical guidelines has been controversial. This commentary reviews the development of sex steroid vascular research, identifies mechanisms by which sex steroids affect vascular function, reviews findings from recent clinical hormone trials, and identifies challenges and the need for continued funding of such investigations.
UR - http://www.scopus.com/inward/record.url?scp=84918507132&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84918507132&partnerID=8YFLogxK
U2 - 10.1089/jwh.2014.4995
DO - 10.1089/jwh.2014.4995
M3 - Article
C2 - 25495365
AN - SCOPUS:84918507132
SN - 1540-9996
VL - 23
SP - 997
EP - 1004
JO - Journal of Women's Health
JF - Journal of Women's Health
IS - 12
ER -