Congestive heart failure despite normal left ventricular systolic function in a population-based sample: The Strong Heart Study

Richard B. Devereux, Mary J. Roman, Jennifer E. Liu, Thomas K. Welty, Elisa T. Lee, Richard Rodeheffer, Richard R. Fabsitz, Barbara V. Howard

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Abstract

In selected clinical series, ≥50% of adults with congestive heart failure (CHF) do not have left ventricular (LV) systolic dysfunction. Little is known of the prevalence of this phenomenon in population samples. Therefore, clinical examination and echocardiography were used in the second examination of the Strong Heart Study (3,184 men and women, 47 to 81 years old) to identify 95 participants with CHF, 50 of whom had normal LV ejection fraction (EF) (>54%), 19 of whom had mildly reduced EF (40% to 54%), and 26 of whom had EF ≤40%. Compared with those with no CHF, participants with CHF and no, mild, or severe decrease in EF had higher creatinine levels (2.34 to 2.85 vs 1.01 mg/dl, p <0.001) and higher prevalences of diabetes (60% to 70% vs 50%) and hypertension (75% to 96% vs 46%, p <0.05). Compared with those with no CHF, participants with CHF and normal EF had prolonged deceleration time (233 vs 204 ms, p <0.05) and a reduced E/A, whereas those with CHF and EF ≤40% had short deceleration time (158 ms, p <0.05) and high E/A (1.70, p <0.001); patients with CHF and normal EF had higher LV mass (98 vs 84 g/m 2, p <0.001) and relative wall thickness (0.37 vs 0.35, p <0.05) than those without CHF. Patients with CHF with normal EF were, compared with those without CHF or with CHF and EF ≤40%, disproportionately women (mean 84% vs 63% and 42%, p <0.001), older (mean 64 vs 60 years and 63 years, respectively, p <0.01), had higher body mass index (mean 33.1 vs 31.0 and 27.7 kg/m 2, p <0.05), and higher systolic blood pressure (mean 137 vs 130 and 128 mm Hg, both p <0.05). Thus, in a population-based sample, patients with CHF and normal LV EF were older and overweight, more often women, had renal dysfunction, impaired early diastolic LV relaxation, and concentric LV geometry, whereas patients with CHF and severe LV dysfunction were more often men, had lower body mass index, a restrictive pattern of LV filling, and eccentric LV hypertrophy. Copyright (C) 2000 Excerpta Medica Inc.

Original languageEnglish (US)
Pages (from-to)1090-1096
Number of pages7
JournalAmerican Journal of Cardiology
Volume86
Issue number10
DOIs
StatePublished - Nov 15 2000

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Left Ventricular Function
Heart Failure
Population
Deceleration
Left Ventricular Dysfunction
Stroke Volume
Body Mass Index
Hypertension
Left Ventricular Hypertrophy
Echocardiography
Creatinine

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Congestive heart failure despite normal left ventricular systolic function in a population-based sample : The Strong Heart Study. / Devereux, Richard B.; Roman, Mary J.; Liu, Jennifer E.; Welty, Thomas K.; Lee, Elisa T.; Rodeheffer, Richard; Fabsitz, Richard R.; Howard, Barbara V.

In: American Journal of Cardiology, Vol. 86, No. 10, 15.11.2000, p. 1090-1096.

Research output: Contribution to journalArticle

Devereux, RB, Roman, MJ, Liu, JE, Welty, TK, Lee, ET, Rodeheffer, R, Fabsitz, RR & Howard, BV 2000, 'Congestive heart failure despite normal left ventricular systolic function in a population-based sample: The Strong Heart Study', American Journal of Cardiology, vol. 86, no. 10, pp. 1090-1096. https://doi.org/10.1016/S0002-9149(00)01165-6
Devereux, Richard B. ; Roman, Mary J. ; Liu, Jennifer E. ; Welty, Thomas K. ; Lee, Elisa T. ; Rodeheffer, Richard ; Fabsitz, Richard R. ; Howard, Barbara V. / Congestive heart failure despite normal left ventricular systolic function in a population-based sample : The Strong Heart Study. In: American Journal of Cardiology. 2000 ; Vol. 86, No. 10. pp. 1090-1096.
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title = "Congestive heart failure despite normal left ventricular systolic function in a population-based sample: The Strong Heart Study",
abstract = "In selected clinical series, ≥50{\%} of adults with congestive heart failure (CHF) do not have left ventricular (LV) systolic dysfunction. Little is known of the prevalence of this phenomenon in population samples. Therefore, clinical examination and echocardiography were used in the second examination of the Strong Heart Study (3,184 men and women, 47 to 81 years old) to identify 95 participants with CHF, 50 of whom had normal LV ejection fraction (EF) (>54{\%}), 19 of whom had mildly reduced EF (40{\%} to 54{\%}), and 26 of whom had EF ≤40{\%}. Compared with those with no CHF, participants with CHF and no, mild, or severe decrease in EF had higher creatinine levels (2.34 to 2.85 vs 1.01 mg/dl, p <0.001) and higher prevalences of diabetes (60{\%} to 70{\%} vs 50{\%}) and hypertension (75{\%} to 96{\%} vs 46{\%}, p <0.05). Compared with those with no CHF, participants with CHF and normal EF had prolonged deceleration time (233 vs 204 ms, p <0.05) and a reduced E/A, whereas those with CHF and EF ≤40{\%} had short deceleration time (158 ms, p <0.05) and high E/A (1.70, p <0.001); patients with CHF and normal EF had higher LV mass (98 vs 84 g/m 2, p <0.001) and relative wall thickness (0.37 vs 0.35, p <0.05) than those without CHF. Patients with CHF with normal EF were, compared with those without CHF or with CHF and EF ≤40{\%}, disproportionately women (mean 84{\%} vs 63{\%} and 42{\%}, p <0.001), older (mean 64 vs 60 years and 63 years, respectively, p <0.01), had higher body mass index (mean 33.1 vs 31.0 and 27.7 kg/m 2, p <0.05), and higher systolic blood pressure (mean 137 vs 130 and 128 mm Hg, both p <0.05). Thus, in a population-based sample, patients with CHF and normal LV EF were older and overweight, more often women, had renal dysfunction, impaired early diastolic LV relaxation, and concentric LV geometry, whereas patients with CHF and severe LV dysfunction were more often men, had lower body mass index, a restrictive pattern of LV filling, and eccentric LV hypertrophy. Copyright (C) 2000 Excerpta Medica Inc.",
author = "Devereux, {Richard B.} and Roman, {Mary J.} and Liu, {Jennifer E.} and Welty, {Thomas K.} and Lee, {Elisa T.} and Richard Rodeheffer and Fabsitz, {Richard R.} and Howard, {Barbara V.}",
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T1 - Congestive heart failure despite normal left ventricular systolic function in a population-based sample

T2 - The Strong Heart Study

AU - Devereux, Richard B.

AU - Roman, Mary J.

AU - Liu, Jennifer E.

AU - Welty, Thomas K.

AU - Lee, Elisa T.

AU - Rodeheffer, Richard

AU - Fabsitz, Richard R.

AU - Howard, Barbara V.

PY - 2000/11/15

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N2 - In selected clinical series, ≥50% of adults with congestive heart failure (CHF) do not have left ventricular (LV) systolic dysfunction. Little is known of the prevalence of this phenomenon in population samples. Therefore, clinical examination and echocardiography were used in the second examination of the Strong Heart Study (3,184 men and women, 47 to 81 years old) to identify 95 participants with CHF, 50 of whom had normal LV ejection fraction (EF) (>54%), 19 of whom had mildly reduced EF (40% to 54%), and 26 of whom had EF ≤40%. Compared with those with no CHF, participants with CHF and no, mild, or severe decrease in EF had higher creatinine levels (2.34 to 2.85 vs 1.01 mg/dl, p <0.001) and higher prevalences of diabetes (60% to 70% vs 50%) and hypertension (75% to 96% vs 46%, p <0.05). Compared with those with no CHF, participants with CHF and normal EF had prolonged deceleration time (233 vs 204 ms, p <0.05) and a reduced E/A, whereas those with CHF and EF ≤40% had short deceleration time (158 ms, p <0.05) and high E/A (1.70, p <0.001); patients with CHF and normal EF had higher LV mass (98 vs 84 g/m 2, p <0.001) and relative wall thickness (0.37 vs 0.35, p <0.05) than those without CHF. Patients with CHF with normal EF were, compared with those without CHF or with CHF and EF ≤40%, disproportionately women (mean 84% vs 63% and 42%, p <0.001), older (mean 64 vs 60 years and 63 years, respectively, p <0.01), had higher body mass index (mean 33.1 vs 31.0 and 27.7 kg/m 2, p <0.05), and higher systolic blood pressure (mean 137 vs 130 and 128 mm Hg, both p <0.05). Thus, in a population-based sample, patients with CHF and normal LV EF were older and overweight, more often women, had renal dysfunction, impaired early diastolic LV relaxation, and concentric LV geometry, whereas patients with CHF and severe LV dysfunction were more often men, had lower body mass index, a restrictive pattern of LV filling, and eccentric LV hypertrophy. Copyright (C) 2000 Excerpta Medica Inc.

AB - In selected clinical series, ≥50% of adults with congestive heart failure (CHF) do not have left ventricular (LV) systolic dysfunction. Little is known of the prevalence of this phenomenon in population samples. Therefore, clinical examination and echocardiography were used in the second examination of the Strong Heart Study (3,184 men and women, 47 to 81 years old) to identify 95 participants with CHF, 50 of whom had normal LV ejection fraction (EF) (>54%), 19 of whom had mildly reduced EF (40% to 54%), and 26 of whom had EF ≤40%. Compared with those with no CHF, participants with CHF and no, mild, or severe decrease in EF had higher creatinine levels (2.34 to 2.85 vs 1.01 mg/dl, p <0.001) and higher prevalences of diabetes (60% to 70% vs 50%) and hypertension (75% to 96% vs 46%, p <0.05). Compared with those with no CHF, participants with CHF and normal EF had prolonged deceleration time (233 vs 204 ms, p <0.05) and a reduced E/A, whereas those with CHF and EF ≤40% had short deceleration time (158 ms, p <0.05) and high E/A (1.70, p <0.001); patients with CHF and normal EF had higher LV mass (98 vs 84 g/m 2, p <0.001) and relative wall thickness (0.37 vs 0.35, p <0.05) than those without CHF. Patients with CHF with normal EF were, compared with those without CHF or with CHF and EF ≤40%, disproportionately women (mean 84% vs 63% and 42%, p <0.001), older (mean 64 vs 60 years and 63 years, respectively, p <0.01), had higher body mass index (mean 33.1 vs 31.0 and 27.7 kg/m 2, p <0.05), and higher systolic blood pressure (mean 137 vs 130 and 128 mm Hg, both p <0.05). Thus, in a population-based sample, patients with CHF and normal LV EF were older and overweight, more often women, had renal dysfunction, impaired early diastolic LV relaxation, and concentric LV geometry, whereas patients with CHF and severe LV dysfunction were more often men, had lower body mass index, a restrictive pattern of LV filling, and eccentric LV hypertrophy. Copyright (C) 2000 Excerpta Medica Inc.

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