TY - JOUR
T1 - Congestion in Acute Heart Failure Syndromes
T2 - An Essential Target of Evaluation and Treatment
AU - Gheorghiade, Mihai
AU - Filippatos, Gerasimos
AU - De Luca, Leonardo
AU - Burnett, John
PY - 2006/12
Y1 - 2006/12
N2 - Patients with acute heart failure syndromes (AHFS) typically present with signs and symptoms of systemic and pulmonary congestion at admission. However, elevated left ventricular (LV) filling pressures (hemodynamic congestion) may be present days or weeks before systemic and pulmonary congestion develop, resulting in hospital admission. This "hemodynamic congestion," with or without clinical congestion, may have deleterious effects including subendocardial ischemia, alterations in LV geometry resulting in secondary mitral insufficiency, and impaired cardiac venous drainage from coronary veins resulting in diastolic dysfunction. It is possible that these hemodynamic abnormalities in addition to neurohormonal activation may contribute to LV remodeling and heart failure progression. Approximately 50% of patients admitted for AHFS are discharged with persistent symptoms and/or minimal or no weight loss in spite of the fact that the main reason for admission was clinical congestion. Accordingly, the assessment and management of pulmonary and systemic congestion in these patients require reevaluation.
AB - Patients with acute heart failure syndromes (AHFS) typically present with signs and symptoms of systemic and pulmonary congestion at admission. However, elevated left ventricular (LV) filling pressures (hemodynamic congestion) may be present days or weeks before systemic and pulmonary congestion develop, resulting in hospital admission. This "hemodynamic congestion," with or without clinical congestion, may have deleterious effects including subendocardial ischemia, alterations in LV geometry resulting in secondary mitral insufficiency, and impaired cardiac venous drainage from coronary veins resulting in diastolic dysfunction. It is possible that these hemodynamic abnormalities in addition to neurohormonal activation may contribute to LV remodeling and heart failure progression. Approximately 50% of patients admitted for AHFS are discharged with persistent symptoms and/or minimal or no weight loss in spite of the fact that the main reason for admission was clinical congestion. Accordingly, the assessment and management of pulmonary and systemic congestion in these patients require reevaluation.
KW - Acute heart failure syndromes
KW - Outcomes
KW - Pulmonary congestion
KW - Treatment
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U2 - 10.1016/j.amjmed.2006.09.011
DO - 10.1016/j.amjmed.2006.09.011
M3 - Article
C2 - 17113398
AN - SCOPUS:33751059230
SN - 0002-9343
VL - 119
SP - S3-S10
JO - American Journal of Medicine
JF - American Journal of Medicine
IS - 12 SUPPL.
ER -