Conformal irradiation for hepatobiliary malignancies

Leonard L. Gunderson, M. G. Haddock, M. L. Foo, T. Todoroki, D. Nagorney

Research output: Contribution to journalArticle

25 Scopus citations

Abstract

The term 'conformal irradiation' is usually used to describe the delivery of sophisticated high dose external beam irradiation (EBRT) with the aid of 3-D treatment planning and the option of both coplanar and non- coplanar beams. Data will be presented from the University of Michigan which suggest that conformal high dose EBRT (48-72.6 Gy) can be used for intrahepatic cancers, both hepatocellular carcinoma (HCC) and intrahepatic cholangiocarcinoma (IHCC), to potentially increase local control and survival over what would be expected with lower dose EBRT. For purpose of this discussion, the term conformal irradiation will be expanded to include other techniques which conform the high dose irradiation boost volume in close proximity to unresected tumor or positive margins of resection. Data will be presented from series which utilize transcatheter iridium and intraoperative electron irradiation (IOERT) supplements to EBRT ± concomitant chemotherapy. Each method intensifies treatment in an attempt to improve local control and survival.

Original languageEnglish (US)
Pages (from-to)S221-S225
JournalAnnals of Oncology
Volume10
Issue numberSUPPL. 4
DOIs
StatePublished - Jan 1 1999

Keywords

  • Bile duct cancer
  • Conformal irradiation
  • Gallbladder cancer
  • Liver cancer

ASJC Scopus subject areas

  • Hematology
  • Oncology

Fingerprint Dive into the research topics of 'Conformal irradiation for hepatobiliary malignancies'. Together they form a unique fingerprint.

  • Cite this

    Gunderson, L. L., Haddock, M. G., Foo, M. L., Todoroki, T., & Nagorney, D. (1999). Conformal irradiation for hepatobiliary malignancies. Annals of Oncology, 10(SUPPL. 4), S221-S225. https://doi.org/10.1093/annonc/10.suppl_4.S221