Confirmation of linkage of prostate cancer aggressiveness with chromosome 19q

S. L. Slager; Daniel J. Schaid; J. M. Cunningham; S. K. McDonnell; A. F. Marks; B. J. Peterson; S. J. Hebbring; S. Anderson; A. J. French; S. N. Thibodeau

doi:10.1086/368230

Confirmation of linkage of prostate cancer aggressiveness with chromosome 19q

S. L. Slager, Daniel J. Schaid, J. M. Cunningham, S. K. McDonnell, A. F. Marks, B. J. Peterson, S. J. Hebbring, S. Anderson, A. J. French, S. N. Thibodeau

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Abstract

Regions on chromosomes 7 and 19 were recently reported to contain susceptibility loci that regulate tumor aggressiveness of prostate cancer. To confirm these findings, we analyzed genome scan data from 161 pedigrees affected with prostate cancer. Using the Gleason score as a quantitative measure of tumor aggressiveness, we regressed the squared trait difference, as well as the mean-corrected cross product, on the estimated proportion of alleles shared identical-by-descent at each marker position. Our results confirm the previous linkage results for chromosome 19q (D19S902, P < .00001). In addition, we report suggestive evidence for linkage on chromosome 4 (D4S403, P = .00012). The results of previous findings, together with our results, provide strong evidence that chromosome 19 harbors a gene for tumor aggressiveness.

Original language	English (US)
Pages (from-to)	759-762
Number of pages	4
Journal	American journal of human genetics
Volume	72
Issue number	3
DOIs	https://doi.org/10.1086/368230
State	Published - Mar 1 2003

ASJC Scopus subject areas

Genetics
Genetics(clinical)

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@article{175629cf5728490395e7dadb954318d4,

title = "Confirmation of linkage of prostate cancer aggressiveness with chromosome 19q",

abstract = "Regions on chromosomes 7 and 19 were recently reported to contain susceptibility loci that regulate tumor aggressiveness of prostate cancer. To confirm these findings, we analyzed genome scan data from 161 pedigrees affected with prostate cancer. Using the Gleason score as a quantitative measure of tumor aggressiveness, we regressed the squared trait difference, as well as the mean-corrected cross product, on the estimated proportion of alleles shared identical-by-descent at each marker position. Our results confirm the previous linkage results for chromosome 19q (D19S902, P < .00001). In addition, we report suggestive evidence for linkage on chromosome 4 (D4S403, P = .00012). The results of previous findings, together with our results, provide strong evidence that chromosome 19 harbors a gene for tumor aggressiveness.",

author = "Slager, {S. L.} and Schaid, {Daniel J.} and Cunningham, {J. M.} and McDonnell, {S. K.} and Marks, {A. F.} and Peterson, {B. J.} and Hebbring, {S. J.} and S. Anderson and French, {A. J.} and Thibodeau, {S. N.}",

note = "Funding Information: This work was supported by National Cancer Institute grants CA 94919 and CA 72818. ",

year = "2003",

month = mar,

day = "1",

doi = "10.1086/368230",

language = "English (US)",

volume = "72",

pages = "759--762",

journal = "American journal of human genetics",

issn = "0002-9297",

publisher = "Cell Press",

number = "3",

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TY - JOUR

T1 - Confirmation of linkage of prostate cancer aggressiveness with chromosome 19q

AU - Slager, S. L.

AU - Schaid, Daniel J.

AU - Cunningham, J. M.

AU - McDonnell, S. K.

AU - Marks, A. F.

AU - Peterson, B. J.

AU - Hebbring, S. J.

AU - Anderson, S.

AU - French, A. J.

AU - Thibodeau, S. N.

N1 - Funding Information: This work was supported by National Cancer Institute grants CA 94919 and CA 72818.

PY - 2003/3/1

Y1 - 2003/3/1

N2 - Regions on chromosomes 7 and 19 were recently reported to contain susceptibility loci that regulate tumor aggressiveness of prostate cancer. To confirm these findings, we analyzed genome scan data from 161 pedigrees affected with prostate cancer. Using the Gleason score as a quantitative measure of tumor aggressiveness, we regressed the squared trait difference, as well as the mean-corrected cross product, on the estimated proportion of alleles shared identical-by-descent at each marker position. Our results confirm the previous linkage results for chromosome 19q (D19S902, P < .00001). In addition, we report suggestive evidence for linkage on chromosome 4 (D4S403, P = .00012). The results of previous findings, together with our results, provide strong evidence that chromosome 19 harbors a gene for tumor aggressiveness.

AB - Regions on chromosomes 7 and 19 were recently reported to contain susceptibility loci that regulate tumor aggressiveness of prostate cancer. To confirm these findings, we analyzed genome scan data from 161 pedigrees affected with prostate cancer. Using the Gleason score as a quantitative measure of tumor aggressiveness, we regressed the squared trait difference, as well as the mean-corrected cross product, on the estimated proportion of alleles shared identical-by-descent at each marker position. Our results confirm the previous linkage results for chromosome 19q (D19S902, P < .00001). In addition, we report suggestive evidence for linkage on chromosome 4 (D4S403, P = .00012). The results of previous findings, together with our results, provide strong evidence that chromosome 19 harbors a gene for tumor aggressiveness.

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DO - 10.1086/368230

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SN - 0002-9297

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EP - 762

JO - American journal of human genetics

JF - American journal of human genetics

IS - 3

ER -

Confirmation of linkage of prostate cancer aggressiveness with chromosome 19q

Abstract

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