Confirmation of a positive association between prostate cancer risk and a locus at chromosome 8q24

Miia Suuriniemi, Ilir Agalliu, Daniel J Schaid, Bo Johanneson, Shannon K. McDonnell, Lori Iwasaki, Janet L. Stanford, Elaine A. Ostrander

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Abstract

Background: Family-based linkage studies, association studies, and studies of tumors have highlighted human chromosome 8q as a genomic region of interest for prostate cancer susceptibility loci. Recently, a locus at 8q24, characterized by both a single nucleotide polymorphism (SNP) and a microsatellite marker, was shown to be associated with prostate cancer risk in Icelandic, Swedish, and U.S. samples. Although the data were provocative, the U.S. samples were not population based, which precludes assessment of the potential contribution of this locus to prostate cancer incidence in the United States. Methods: We analyzed both markers in a population-based, case-control study of middle-aged men from King County, Washington. Results: Overall, there was a significant positive association between the A allele of the SNP rs1447295 and prostate cancer risk [odds ratio, 1.4; 95% confidence interval (95% CI), 1.1-2.0] but no significant association with the microsatellite DG8S737. However, significant associations were observed for both markers in men with high Gleason scores. Adjusting for age, first-degree family history of prostate cancer, and prostate cancer screening history, the adjusted odds ratios were 1.4 (95% CI, 1.1-1.8) for the A allele of the SNP and 1.9 (95% CI, 1.2-2.8) for the -10 allele of the microsatellite. Conclusions: These data suggest that the locus on chromosome 8q24 harbors a genetic variant associated with prostate cancer and that the microsatellite marker is a stronger risk factor for aggressive prostate cancers defined by poorly differentiated tumor morphology.

Original languageEnglish (US)
Pages (from-to)809-814
Number of pages6
JournalCancer Epidemiology Biomarkers and Prevention
Volume16
Issue number4
DOIs
StatePublished - Apr 2007

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Prostatic Neoplasms
Chromosomes
Microsatellite Repeats
Single Nucleotide Polymorphism
Alleles
Odds Ratio
Confidence Intervals
Neoplasm Grading
Human Chromosomes
Early Detection of Cancer
Population
Case-Control Studies
Neoplasms
History
Incidence

ASJC Scopus subject areas

  • Epidemiology
  • Oncology

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Confirmation of a positive association between prostate cancer risk and a locus at chromosome 8q24. / Suuriniemi, Miia; Agalliu, Ilir; Schaid, Daniel J; Johanneson, Bo; McDonnell, Shannon K.; Iwasaki, Lori; Stanford, Janet L.; Ostrander, Elaine A.

In: Cancer Epidemiology Biomarkers and Prevention, Vol. 16, No. 4, 04.2007, p. 809-814.

Research output: Contribution to journalArticle

Suuriniemi, M, Agalliu, I, Schaid, DJ, Johanneson, B, McDonnell, SK, Iwasaki, L, Stanford, JL & Ostrander, EA 2007, 'Confirmation of a positive association between prostate cancer risk and a locus at chromosome 8q24', Cancer Epidemiology Biomarkers and Prevention, vol. 16, no. 4, pp. 809-814. https://doi.org/10.1158/1055-9965.EPI-06-1049
Suuriniemi, Miia ; Agalliu, Ilir ; Schaid, Daniel J ; Johanneson, Bo ; McDonnell, Shannon K. ; Iwasaki, Lori ; Stanford, Janet L. ; Ostrander, Elaine A. / Confirmation of a positive association between prostate cancer risk and a locus at chromosome 8q24. In: Cancer Epidemiology Biomarkers and Prevention. 2007 ; Vol. 16, No. 4. pp. 809-814.
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abstract = "Background: Family-based linkage studies, association studies, and studies of tumors have highlighted human chromosome 8q as a genomic region of interest for prostate cancer susceptibility loci. Recently, a locus at 8q24, characterized by both a single nucleotide polymorphism (SNP) and a microsatellite marker, was shown to be associated with prostate cancer risk in Icelandic, Swedish, and U.S. samples. Although the data were provocative, the U.S. samples were not population based, which precludes assessment of the potential contribution of this locus to prostate cancer incidence in the United States. Methods: We analyzed both markers in a population-based, case-control study of middle-aged men from King County, Washington. Results: Overall, there was a significant positive association between the A allele of the SNP rs1447295 and prostate cancer risk [odds ratio, 1.4; 95{\%} confidence interval (95{\%} CI), 1.1-2.0] but no significant association with the microsatellite DG8S737. However, significant associations were observed for both markers in men with high Gleason scores. Adjusting for age, first-degree family history of prostate cancer, and prostate cancer screening history, the adjusted odds ratios were 1.4 (95{\%} CI, 1.1-1.8) for the A allele of the SNP and 1.9 (95{\%} CI, 1.2-2.8) for the -10 allele of the microsatellite. Conclusions: These data suggest that the locus on chromosome 8q24 harbors a genetic variant associated with prostate cancer and that the microsatellite marker is a stronger risk factor for aggressive prostate cancers defined by poorly differentiated tumor morphology.",
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AU - Suuriniemi, Miia

AU - Agalliu, Ilir

AU - Schaid, Daniel J

AU - Johanneson, Bo

AU - McDonnell, Shannon K.

AU - Iwasaki, Lori

AU - Stanford, Janet L.

AU - Ostrander, Elaine A.

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N2 - Background: Family-based linkage studies, association studies, and studies of tumors have highlighted human chromosome 8q as a genomic region of interest for prostate cancer susceptibility loci. Recently, a locus at 8q24, characterized by both a single nucleotide polymorphism (SNP) and a microsatellite marker, was shown to be associated with prostate cancer risk in Icelandic, Swedish, and U.S. samples. Although the data were provocative, the U.S. samples were not population based, which precludes assessment of the potential contribution of this locus to prostate cancer incidence in the United States. Methods: We analyzed both markers in a population-based, case-control study of middle-aged men from King County, Washington. Results: Overall, there was a significant positive association between the A allele of the SNP rs1447295 and prostate cancer risk [odds ratio, 1.4; 95% confidence interval (95% CI), 1.1-2.0] but no significant association with the microsatellite DG8S737. However, significant associations were observed for both markers in men with high Gleason scores. Adjusting for age, first-degree family history of prostate cancer, and prostate cancer screening history, the adjusted odds ratios were 1.4 (95% CI, 1.1-1.8) for the A allele of the SNP and 1.9 (95% CI, 1.2-2.8) for the -10 allele of the microsatellite. Conclusions: These data suggest that the locus on chromosome 8q24 harbors a genetic variant associated with prostate cancer and that the microsatellite marker is a stronger risk factor for aggressive prostate cancers defined by poorly differentiated tumor morphology.

AB - Background: Family-based linkage studies, association studies, and studies of tumors have highlighted human chromosome 8q as a genomic region of interest for prostate cancer susceptibility loci. Recently, a locus at 8q24, characterized by both a single nucleotide polymorphism (SNP) and a microsatellite marker, was shown to be associated with prostate cancer risk in Icelandic, Swedish, and U.S. samples. Although the data were provocative, the U.S. samples were not population based, which precludes assessment of the potential contribution of this locus to prostate cancer incidence in the United States. Methods: We analyzed both markers in a population-based, case-control study of middle-aged men from King County, Washington. Results: Overall, there was a significant positive association between the A allele of the SNP rs1447295 and prostate cancer risk [odds ratio, 1.4; 95% confidence interval (95% CI), 1.1-2.0] but no significant association with the microsatellite DG8S737. However, significant associations were observed for both markers in men with high Gleason scores. Adjusting for age, first-degree family history of prostate cancer, and prostate cancer screening history, the adjusted odds ratios were 1.4 (95% CI, 1.1-1.8) for the A allele of the SNP and 1.9 (95% CI, 1.2-2.8) for the -10 allele of the microsatellite. Conclusions: These data suggest that the locus on chromosome 8q24 harbors a genetic variant associated with prostate cancer and that the microsatellite marker is a stronger risk factor for aggressive prostate cancers defined by poorly differentiated tumor morphology.

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