Conditional cancer-specific versus cardiovascular-specific survival after lobectomy for stage i non-small cell lung cancer

Shawn S. Groth, Natasha M. Rueth, James S. Hodges, Elizabeth B Habermann, Rafael S. Andrade, Jonathan D'Cunha, Michael A. Maddaus

Research output: Contribution to journalArticle

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Abstract

Background: Conditional cancer-specific survival rates account for changes in the risk of death from cancer over time. There may be a point during follow-up when patients who undergo lobectomy for stage I non-small cell lung cancer (NSCLC) are as likely to die of cardiovascular disease as of cancer. Methods: Using the Surveillance Epidemiology and End Results Database (1988 through 2005), we identified patients 50 years old and older who underwent lobectomy for stage I NSCLC. We used competing risks methods to calculate conditional survival rates and to ascertain if there is a point in follow-up where the risk of dying of cancer is equivalent to the risk of dying of cardiovascular disease. Results: In all, 22,518 patients met our inclusion criteria. The difference in the 5-year conditional probability of dying of cancer and the 5-year conditional probability of dying of cardiovascular disease decreased with time; in the whole cohort, these probabilities were equivalent if patients survived to 7 years after lobectomy (p = 0.11). With increasing age, the probability of dying of cancer and the probability of dying of cardiovascular disease became equivalent at earlier time points. Furthermore, the 5-year probability of dying of cardiovascular disease was significantly greater than the 5-year probability of dying of cancer for patients aged 70 to 79 years who survived to 7 years and for patients aged 80 years and older who survived to 5 years after lobectomy. Conclusions: For patients undergoing lobectomy for stage I NSCLC, cardiovascular-specific mortality becomes increasingly important over the course of follow-up, especially among elderly patients.

Original languageEnglish (US)
Pages (from-to)375-381
Number of pages7
JournalAnnals of Thoracic Surgery
Volume90
Issue number2
DOIs
StatePublished - Aug 2010
Externally publishedYes

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Non-Small Cell Lung Carcinoma
Survival
Cardiovascular Diseases
Neoplasms
Survival Rate
Epidemiology
Databases
Mortality

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Surgery
  • Pulmonary and Respiratory Medicine

Cite this

Conditional cancer-specific versus cardiovascular-specific survival after lobectomy for stage i non-small cell lung cancer. / Groth, Shawn S.; Rueth, Natasha M.; Hodges, James S.; Habermann, Elizabeth B; Andrade, Rafael S.; D'Cunha, Jonathan; Maddaus, Michael A.

In: Annals of Thoracic Surgery, Vol. 90, No. 2, 08.2010, p. 375-381.

Research output: Contribution to journalArticle

Groth, Shawn S. ; Rueth, Natasha M. ; Hodges, James S. ; Habermann, Elizabeth B ; Andrade, Rafael S. ; D'Cunha, Jonathan ; Maddaus, Michael A. / Conditional cancer-specific versus cardiovascular-specific survival after lobectomy for stage i non-small cell lung cancer. In: Annals of Thoracic Surgery. 2010 ; Vol. 90, No. 2. pp. 375-381.
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