Concise two-step solution phase syntheses of four novel dihydroquinazoline scaffolds

Justin Dietrich, Christine Kaiser, Nathalie Meurice, Christopher Hulme

Research output: Contribution to journalArticle

26 Scopus citations

Abstract

Novel two-step solution phase protocols for the synthesis of dihydroquinazolines and fused dihydroquinazoline-benzodiazepine tetracycles are reported. The methodology employs the Ugi reaction to assemble the desired diversity and acid treatment enables ring-closing transformations. The protocols are further facilitated by the use of microwave irradiation and n-butyl isocyanide to control the rate of each ring-forming transformation.

Original languageEnglish (US)
Pages (from-to)3951-3955
Number of pages5
JournalTetrahedron Letters
Volume51
Issue number30
DOIs
StatePublished - Jul 28 2010

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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