Concise review: Mesenchymal stem cell treatment for ischemic kidney disease

Xiang Yang Zhu, Amir Lerman, Lilach O. Lerman

Research output: Contribution to journalArticlepeer-review

48 Scopus citations

Abstract

Ischemic kidney diseases are common clinical entities that bear high mortality and morbidity and may lead to irreversible loss of kidney function. Their pathophysiology is multifaceted, involves complex hormonal-immunological- cellular interactions, and leads to damage in multiple cell types, which is often resistant to conventional therapy. Thus, novel strategies are needed to repair the renal parenchyma and preserve kidney function. Mesenchymal stem cells (MSC) confer renal protection through paracrine/endocrine effects and to some degree possibly by direct engraftment. Their anti-inflammatory and immune-modulatory properties target multiple cascades in the mechanisms of ischemic kidney disease. This review focuses on recent progress on the use of MSC to prevent kidney injury in ischemic kidney injury, with a focus on the chronic form. Stem Cells 2013;31:1731-1736

Original languageEnglish (US)
Pages (from-to)1731-1736
Number of pages6
JournalStem Cells
Volume31
Issue number9
DOIs
StatePublished - Sep 2013

Keywords

  • Cellular therapy
  • Inflammation
  • Kidney
  • Mesenchymal stem cells

ASJC Scopus subject areas

  • Molecular Medicine
  • Developmental Biology
  • Cell Biology

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