Computing the Cox Model for Case Cohort Designs

Terry M. Therneau, Hongzhe Li

Research output: Contribution to journalArticle

90 Scopus citations


Prentice (1986) proposed a case-cohort design as an efficient subsampling mechanism for survival studies. Several other authors have expanded on these ideas to create a family of related sampling plans, along with estimators for the covariate effects. We describe how to obtain the proposed parameter estimates and their variance estimates using standard software packages, with SAS and S-Plus as particular examples.

Original languageEnglish (US)
Pages (from-to)99-112
Number of pages14
JournalLifetime Data Analysis
Issue number2
StatePublished - Dec 1 1999



  • Case-cohort design
  • Cox model
  • Finite sampling
  • Jackknife estimate
  • Robust variance

ASJC Scopus subject areas

  • Applied Mathematics

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