Computer-assisted identification and quantification of multiple sclerosis lesions in MR imaging volumes in the brain.

Joseph Ross Mitchell, S. J. Karlik, D. H. Lee, A. Fenster

Research output: Contribution to journalArticle

77 Citations (Scopus)

Abstract

Magnetic resonance (MR) imaging is the principal imaging technique for the diagnosis of multiple sclerosis (MS). However, quantifying the number and extent of lesions on MR images manually is arduous. The authors have developed a computerized three-dimensional (3D) quantitative system to assist in the identification and analysis of MS lesions in proton-density (PD)- and T2-weighted volumes of the head. The system provides intuitive, interactive operations that allow flexible extraction of information from the data. Use of the system to analyze MR examinations of a phantom containing regular "lesions" showed that accurate (average error, < 0.21 cm3) and precise (10% or better for lesions > 1 cm3) measurements of objects less than 7 cm3 is possible, and that an estimate of the quantization error predicted the uncertainty in the volume. Analysis of four MR examinations of a chronic-progressive MS patient conducted over an 18-month period was performed. A two-dimensional histogram showing the frequency of voxels with particular PD- and T2-weighted intensities revealed a distinct cluster only in histograms of sections that contained lesions. Measurements and 3D volume rendering of lesions clearly showed changes in lesion shape, position, and size.

Original languageEnglish (US)
Pages (from-to)197-208
Number of pages12
JournalJournal of magnetic resonance imaging : JMRI
Volume4
Issue number2
StatePublished - Mar 1994
Externally publishedYes

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Multiple Sclerosis
Magnetic Resonance Spectroscopy
Magnetic Resonance Imaging
Protons
Brain
Chronic Progressive Multiple Sclerosis
Information Storage and Retrieval
Uncertainty
Head

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology

Cite this

Computer-assisted identification and quantification of multiple sclerosis lesions in MR imaging volumes in the brain. / Mitchell, Joseph Ross; Karlik, S. J.; Lee, D. H.; Fenster, A.

In: Journal of magnetic resonance imaging : JMRI, Vol. 4, No. 2, 03.1994, p. 197-208.

Research output: Contribution to journalArticle

Mitchell, Joseph Ross ; Karlik, S. J. ; Lee, D. H. ; Fenster, A. / Computer-assisted identification and quantification of multiple sclerosis lesions in MR imaging volumes in the brain. In: Journal of magnetic resonance imaging : JMRI. 1994 ; Vol. 4, No. 2. pp. 197-208.
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