TY - JOUR
T1 - Computer-assisted alignment and tracking of acne lesions indicate that most inflammatory lesions arise from comedones and de novo
AU - Do, Thy Thy
AU - Zarkhin, Semyon
AU - Orringer, Jeffrey S.
AU - Nemeth, Shari
AU - Hamilton, Ted
AU - Sachs, Dana
AU - Voorhees, John J.
AU - Kang, Sewon
PY - 2008/4
Y1 - 2008/4
N2 - Background: Inflammatory acne lesions are believed to derive from comedones; however, their evolution has not been rigorously studied. Objective: To examine the evolution of facial acne lesions using serial digital photographs and spatial alignment software. Methods: Six predefined lesion types, including inflammatory lesions, were counted and tracked from photographs taken every 2 weeks for 12 weeks from 25 individuals with untreated facial acne. Results: Closed comedones occurred most frequently (37%), followed by erythematous macules (26%), inflammatory papules (15%), open comedones (12%), pustules (2%), and nodules (1%). Inflammatory lesions were preceded by comedones (54%), normal-appearing skin (28%), erythematous macules (12%), and scars (6%). Limitations: Lesions could have appeared and resolved within the 2-week intervals and some comedones may have been too small to identify on digital photographs. Conclusion: Our results confirm the comedonal origin of the majority of inflammatory acne lesions. However, a sizeable number (28%) appear to arise from normal skin.
AB - Background: Inflammatory acne lesions are believed to derive from comedones; however, their evolution has not been rigorously studied. Objective: To examine the evolution of facial acne lesions using serial digital photographs and spatial alignment software. Methods: Six predefined lesion types, including inflammatory lesions, were counted and tracked from photographs taken every 2 weeks for 12 weeks from 25 individuals with untreated facial acne. Results: Closed comedones occurred most frequently (37%), followed by erythematous macules (26%), inflammatory papules (15%), open comedones (12%), pustules (2%), and nodules (1%). Inflammatory lesions were preceded by comedones (54%), normal-appearing skin (28%), erythematous macules (12%), and scars (6%). Limitations: Lesions could have appeared and resolved within the 2-week intervals and some comedones may have been too small to identify on digital photographs. Conclusion: Our results confirm the comedonal origin of the majority of inflammatory acne lesions. However, a sizeable number (28%) appear to arise from normal skin.
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U2 - 10.1016/j.jaad.2007.12.024
DO - 10.1016/j.jaad.2007.12.024
M3 - Article
C2 - 18249468
AN - SCOPUS:40649121682
SN - 0190-9622
VL - 58
SP - 603
EP - 608
JO - Journal of the American Academy of Dermatology
JF - Journal of the American Academy of Dermatology
IS - 4
ER -