Computer-assisted alignment and tracking of acne lesions indicate that most inflammatory lesions arise from comedones and de novo

Thy Thy Do, Semyon Zarkhin, Jeffrey S. Orringer, Shari Nemeth, Ted Hamilton, Dana Sachs, John J. Voorhees, Sewon Kang

Research output: Contribution to journalArticle

38 Scopus citations

Abstract

Background: Inflammatory acne lesions are believed to derive from comedones; however, their evolution has not been rigorously studied. Objective: To examine the evolution of facial acne lesions using serial digital photographs and spatial alignment software. Methods: Six predefined lesion types, including inflammatory lesions, were counted and tracked from photographs taken every 2 weeks for 12 weeks from 25 individuals with untreated facial acne. Results: Closed comedones occurred most frequently (37%), followed by erythematous macules (26%), inflammatory papules (15%), open comedones (12%), pustules (2%), and nodules (1%). Inflammatory lesions were preceded by comedones (54%), normal-appearing skin (28%), erythematous macules (12%), and scars (6%). Limitations: Lesions could have appeared and resolved within the 2-week intervals and some comedones may have been too small to identify on digital photographs. Conclusion: Our results confirm the comedonal origin of the majority of inflammatory acne lesions. However, a sizeable number (28%) appear to arise from normal skin.

Original languageEnglish (US)
Pages (from-to)603-608
Number of pages6
JournalJournal of the American Academy of Dermatology
Volume58
Issue number4
DOIs
StatePublished - Apr 1 2008

ASJC Scopus subject areas

  • Dermatology

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