Computer-Aided Nodule Assessment and Risk Yield Risk Management of Adenocarcinoma: The Future of Imaging?

Finbar Foley, Srinivasan Rajagopalan, Sushravya M. Raghunath, Jennifer M. Boland, Ronald A. Karwoski, Fabien Maldonado, Brian Jack Bartholmai, Tobias D Peikert

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Increased clinical use of chest high-resolution computed tomography results in increased identification of lung adenocarcinomas and persistent subsolid opacities. However, these lesions range from very indolent to extremely aggressive tumors. Clinically relevant diagnostic tools to noninvasively risk stratify and guide individualized management of these lesions are lacking. Research efforts investigating semiquantitative measures to decrease interrater and intrarater variability are emerging, and in some cases steps have been taken to automate this process. However, many such methods currently are still suboptimal, require validation and are not yet clinically applicable. The computer-aided nodule assessment and risk yield software application represents a validated tool for the automated, quantitative, and noninvasive tool for risk stratification of adenocarcinoma lung nodules. Computer-aided nodule assessment and risk yield correlates well with consensus histology and postsurgical patient outcomes, and therefore may help to guide individualized patient management, for example, in identification of nodules amenable to radiological surveillance, or in need of adjunctive therapy.

Original languageEnglish (US)
JournalSeminars in Thoracic and Cardiovascular Surgery
DOIs
StateAccepted/In press - 2016

Fingerprint

Risk Management
Adenocarcinoma
Histology
Thorax
Software
Tomography
Research
Neoplasms
Adenocarcinoma of lung
Therapeutics

Keywords

  • Lung adenocarcinoma
  • Lung cancer screening
  • Pulmonary nodule
  • Quantitative image analytics
  • Risk stratification

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Surgery
  • Pulmonary and Respiratory Medicine

Cite this

Computer-Aided Nodule Assessment and Risk Yield Risk Management of Adenocarcinoma : The Future of Imaging? / Foley, Finbar; Rajagopalan, Srinivasan; Raghunath, Sushravya M.; Boland, Jennifer M.; Karwoski, Ronald A.; Maldonado, Fabien; Bartholmai, Brian Jack; Peikert, Tobias D.

In: Seminars in Thoracic and Cardiovascular Surgery, 2016.

Research output: Contribution to journalArticle

Foley, Finbar ; Rajagopalan, Srinivasan ; Raghunath, Sushravya M. ; Boland, Jennifer M. ; Karwoski, Ronald A. ; Maldonado, Fabien ; Bartholmai, Brian Jack ; Peikert, Tobias D. / Computer-Aided Nodule Assessment and Risk Yield Risk Management of Adenocarcinoma : The Future of Imaging?. In: Seminars in Thoracic and Cardiovascular Surgery. 2016.
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