Computed tomography assessment of bone lesions in patients with POEMS syndrome

K. Glazebrook; Francis L. Guerra Bonilla; Adam Johnson; S. Leng; A. Dispenzieri

doi:10.1007/s00330-014-3428-y

Computed tomography assessment of bone lesions in patients with POEMS syndrome

K. Glazebrook, Francis L. Guerra Bonilla, Adam Johnson, S. Leng, A. Dispenzieri

Research output: Contribution to journal › Article › peer-review

21 Scopus citations

Abstract

Objectives: To describe the imaging findings on computed tomography (CT) and skeletal survey (SS) in patients with POEMS syndrome.

Methods: We retrospectively reviewed, with institutional review board approval, the dysproteinemia database at our institution for patients with new diagnosis of POEMS syndrome between January 1998 and December 2008. Twenty-four patients were identified with PET/CT or CT and had skeletal survey (SS) available for review.

Results: Twenty-four patients were included in the study group with median age of 47 years. All CTs demonstrated at least one sclerotic lesion. The most common pattern was multiple small lesions, with 18 patients (75 %) having at least 5 lesions less than 1 cm. The larger lesions had a central lytic component and were FDG avid. SS had a false negative rate of 36 % (8 patients). Serial CT after treatment showed a decrease in size and number of sclerotic lesions in 53 % of cases (13 patients), the majority showing increased sclerosis. Two patients had complete resolution of sclerotic lesions.

Conclusions: CT identified sclerotic lesions in all study patients with POEMS syndrome, the majority being less than 1 cm in size, which were not identified radiographically. CT may demonstrate increased sclerosis or even resolution of sclerotic lesions corresponding to treatment response.

Key

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Original language	English (US)
Pages (from-to)	497-504
Number of pages	8
Journal	European radiology
Volume	25
Issue number	2
DOIs	https://doi.org/10.1007/s00330-014-3428-y
State	Published - Feb 2015

Keywords

Computed tomography
POEMS syndrome
Radiography
Sclerosis
Skeletal survey (SS)

ASJC Scopus subject areas

Radiology Nuclear Medicine and imaging

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title = "Computed tomography assessment of bone lesions in patients with POEMS syndrome",

abstract = "Objectives: To describe the imaging findings on computed tomography (CT) and skeletal survey (SS) in patients with POEMS syndrome.Methods: We retrospectively reviewed, with institutional review board approval, the dysproteinemia database at our institution for patients with new diagnosis of POEMS syndrome between January 1998 and December 2008. Twenty-four patients were identified with PET/CT or CT and had skeletal survey (SS) available for review.Results: Twenty-four patients were included in the study group with median age of 47 years. All CTs demonstrated at least one sclerotic lesion. The most common pattern was multiple small lesions, with 18 patients (75 %) having at least 5 lesions less than 1 cm. The larger lesions had a central lytic component and were FDG avid. SS had a false negative rate of 36 % (8 patients). Serial CT after treatment showed a decrease in size and number of sclerotic lesions in 53 % of cases (13 patients), the majority showing increased sclerosis. Two patients had complete resolution of sclerotic lesions.Conclusions: CT identified sclerotic lesions in all study patients with POEMS syndrome, the majority being less than 1 cm in size, which were not identified radiographically. CT may demonstrate increased sclerosis or even resolution of sclerotic lesions corresponding to treatment response.Key••••",

keywords = "Computed tomography, POEMS syndrome, Radiography, Sclerosis, Skeletal survey (SS)",

author = "K. Glazebrook and {Guerra Bonilla}, {Francis L.} and Adam Johnson and S. Leng and A. Dispenzieri",

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T1 - Computed tomography assessment of bone lesions in patients with POEMS syndrome

AU - Glazebrook, K.

AU - Guerra Bonilla, Francis L.

AU - Johnson, Adam

AU - Leng, S.

AU - Dispenzieri, A.

PY - 2015/2

Y1 - 2015/2

N2 - Objectives: To describe the imaging findings on computed tomography (CT) and skeletal survey (SS) in patients with POEMS syndrome.Methods: We retrospectively reviewed, with institutional review board approval, the dysproteinemia database at our institution for patients with new diagnosis of POEMS syndrome between January 1998 and December 2008. Twenty-four patients were identified with PET/CT or CT and had skeletal survey (SS) available for review.Results: Twenty-four patients were included in the study group with median age of 47 years. All CTs demonstrated at least one sclerotic lesion. The most common pattern was multiple small lesions, with 18 patients (75 %) having at least 5 lesions less than 1 cm. The larger lesions had a central lytic component and were FDG avid. SS had a false negative rate of 36 % (8 patients). Serial CT after treatment showed a decrease in size and number of sclerotic lesions in 53 % of cases (13 patients), the majority showing increased sclerosis. Two patients had complete resolution of sclerotic lesions.Conclusions: CT identified sclerotic lesions in all study patients with POEMS syndrome, the majority being less than 1 cm in size, which were not identified radiographically. CT may demonstrate increased sclerosis or even resolution of sclerotic lesions corresponding to treatment response.Key••••

AB - Objectives: To describe the imaging findings on computed tomography (CT) and skeletal survey (SS) in patients with POEMS syndrome.Methods: We retrospectively reviewed, with institutional review board approval, the dysproteinemia database at our institution for patients with new diagnosis of POEMS syndrome between January 1998 and December 2008. Twenty-four patients were identified with PET/CT or CT and had skeletal survey (SS) available for review.Results: Twenty-four patients were included in the study group with median age of 47 years. All CTs demonstrated at least one sclerotic lesion. The most common pattern was multiple small lesions, with 18 patients (75 %) having at least 5 lesions less than 1 cm. The larger lesions had a central lytic component and were FDG avid. SS had a false negative rate of 36 % (8 patients). Serial CT after treatment showed a decrease in size and number of sclerotic lesions in 53 % of cases (13 patients), the majority showing increased sclerosis. Two patients had complete resolution of sclerotic lesions.Conclusions: CT identified sclerotic lesions in all study patients with POEMS syndrome, the majority being less than 1 cm in size, which were not identified radiographically. CT may demonstrate increased sclerosis or even resolution of sclerotic lesions corresponding to treatment response.Key••••

KW - Computed tomography

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KW - Sclerosis

KW - Skeletal survey (SS)

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Computed tomography assessment of bone lesions in patients with POEMS syndrome

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