Computational analysis of muscular dystrophy sub-types using a novel integrative scheme

Chen Wang, Sook Ha, Jianhua Xuan, Yue Wang, Eric Hoffman

Research output: Contribution to journalArticle

1 Scopus citations

Abstract

To construct biologically interpretable gene sets for muscular dystrophy (MD) sub-type classification, we propose a novel computational scheme to integrate protein-protein interaction (PPI) network, functional gene set information, and mRNA profiling data. The workflow of the proposed scheme includes the following three major steps: firstly, we apply an affinity propagation clustering (APC) approach to identify gene sub-networks associated with each MD sub-type, in which a new distance metric is proposed for APC to combine PPI network information and gene-gene co-expression relationship; secondly, we further incorporate functional gene set knowledge, which complements the physical PPI information, into our scheme for biomarker identification; finally, based on the constructed sub-networks and gene set features, we apply multiclass support vector machines (MSVMs) for MD sub-type classification, with which to highlight the biomarkers contributing to sub-type prediction. The experimental results show that our scheme can help identify sub-networks and gene sets that are more relevant to MD than those constructed by other conventional approaches. Moreover, our integrative strategy improves the prediction accuracy substantially, especially for those 'hard-to-classify' sub-types.

Original languageEnglish (US)
Pages (from-to)9-17
Number of pages9
JournalNeurocomputing
Volume92
DOIs
StatePublished - Sep 1 2012

Keywords

  • Affinity propagation clustering
  • Biomarker discovery
  • Classification
  • Gene expression
  • Muscular dystrophy

ASJC Scopus subject areas

  • Computer Science Applications
  • Cognitive Neuroscience
  • Artificial Intelligence

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