Comprehensively understanding fatigue in patients with myeloproliferative neoplasms

Robyn M. Scherber, Heidi E. Kosiorek, Zhenya Senyak, Amylou Dueck, Matthew M Clark, Michael A. Boxer, Holly L. Geyer, Archie Mccallister, Mary Cotter, Barbara Van Husen, Claire N. Harrison, Ruben A. Mesa

Research output: Contribution to journalArticle

24 Scopus citations


BACKGROUND: Patients with myeloproliferative neoplasms (MPNs) experience a high persistence, prevalence, and severity of fatigue. There is currently only limited information regarding factors that contribute to fatigue in patients with MPNs. METHODS: A 70-item, Internet-based survey regarding fatigue was developed by MPN investigators and patients/advocates and hosted by the Mayo Clinic Survey Research Center. RESULTS: Fatigue was found to be prevalent and severe among international survey respondents (1788 respondents). Higher body mass index (P2 on the Patient Health Questionnaire, indicating a high probability of depression. Higher Brief Fatigue Inventory score, Myeloproliferative Neoplasm Total Symptom Score, and individual symptom items were all associated with a higher likelihood of depressive symptoms (P

Original languageEnglish (US)
StateAccepted/In press - 2015


  • Essential thrombocythemia
  • Fatigue
  • Myelofibrosis
  • Polycythemia vera
  • Quality of life

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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    Scherber, R. M., Kosiorek, H. E., Senyak, Z., Dueck, A., Clark, M. M., Boxer, M. A., Geyer, H. L., Mccallister, A., Cotter, M., Van Husen, B., Harrison, C. N., & Mesa, R. A. (Accepted/In press). Comprehensively understanding fatigue in patients with myeloproliferative neoplasms. Cancer.