Comprehensive study of cardiovascular morbidity in hospitalized inflammatory bowel disease patients

Arun Raghav Mahankali Sridhar, Sravanthi Parasa, Udayakumar Navaneethan, Michael D. Crowell, Kevin Olden

Research output: Contribution to journalArticle

36 Citations (Scopus)

Abstract

Background: The full extent of cardiovascular morbidity in inflammatory bowel disease is not well understood. Objective: To comprehensively study the association of different cardiovascular diseases in hospitalized patients with inflammatory bowel disease (IBD) using a large database. Methods: We used the Nationwide Inpatient Sample (NIS) database to perform a cross-sectional study. The study group was defined as all hospitalized patients between ages 18-60 years included in the NIS 2006 database with a discharge diagnosis of IBD, as per the International Classification of Diseases - Clinical Modification, 9th revision (ICD-9-CM) codes. Individuals in the same age group whose hospital discharge records did not note IBD were identified as the control group. Cardiovascular diseases, identified by the ICD-9-CM codes, were studied comprehensively for their association with IBD using multivariate logistic regression analysis. Odds ratios were calculated adjusting for relevant patient comorbidities. Results: IBD was found to be strongly associated with mesenteric ischemia (adjusted odds ratio (aOR), 3.4; 95% confidence interval (CI), 2.9-4.0) and venous thrombotic diseases (aOR, 1.38; 95% CI, 1.25-1.53). Age and gender stratified analysis revealed that IBD is positively associated with dysrhythmias in females aged 18-39 years (aOR, 2.05; 95% CI, 1.72-2.44). We did not find an increased risk of other cardiovascular diseases in IBD patients. Conclusions: Our study substantiates the previously reported associations of mesenteric ischemia and venous thrombotic disorders with IBD. Our study also suggests that young females with IBD might have an increased risk for dysrhythmias.

Original languageEnglish (US)
Pages (from-to)287-294
Number of pages8
JournalJournal of Crohn's and Colitis
Volume5
Issue number4
DOIs
StatePublished - Sep 2011

Fingerprint

Inflammatory Bowel Diseases
Morbidity
International Classification of Diseases
Odds Ratio
Cardiovascular Diseases
Databases
Confidence Intervals
Inpatients
Hospital Records
Comorbidity
Age Groups
Cross-Sectional Studies
Logistic Models
Regression Analysis
Control Groups

Keywords

  • Arterial thromboembolic events
  • Cardiovascular morbidity
  • Crohn's disease
  • Dysrhythmias
  • Inflammatory bowel disease
  • Ulcerative colitis

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Comprehensive study of cardiovascular morbidity in hospitalized inflammatory bowel disease patients. / Sridhar, Arun Raghav Mahankali; Parasa, Sravanthi; Navaneethan, Udayakumar; Crowell, Michael D.; Olden, Kevin.

In: Journal of Crohn's and Colitis, Vol. 5, No. 4, 09.2011, p. 287-294.

Research output: Contribution to journalArticle

Sridhar, Arun Raghav Mahankali ; Parasa, Sravanthi ; Navaneethan, Udayakumar ; Crowell, Michael D. ; Olden, Kevin. / Comprehensive study of cardiovascular morbidity in hospitalized inflammatory bowel disease patients. In: Journal of Crohn's and Colitis. 2011 ; Vol. 5, No. 4. pp. 287-294.
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