Comprehensive Left Atrial Appendage Optimization of Thrombus Using Surface Echocardiography

The CLOTS Multicenter Pilot Trial

John A. Sallach, Sarinya Puwanant, Jeanne K. Drinko, Sukaina Jaffer, Erwan Donal, Senthil K. Thambidorai, Craig R. Asher, Wael A. Jaber, Marcus F. Stoddard, William A. Zoghbi, Neil J. Weissmann, Sharon L. Mulvagh, Joseph F. Malouf, Susan E. Jasper, Allen G. Borowski, Carolyn Apperson-Hansen, Elizabeth A. Lieber, Jianbo Li, Allan L. Klein

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

Background: The aim of this study was to determine the ability to identify thrombus within the left atrial appendage (LAA) in the setting of atrial fibrillation (AF) using transthoracic echocardiography (TTE). In AF, the structure and function of the LAA has historically been evaluated using transesophageal echocardiography (TEE). The role of TTE remains undefined. Methods: The Comprehensive Left Atrial Appendage Optimization of Thrombus (CLOTS) multicenter study enrolled 118 patients (85 men; mean age, 67 ± 13 years) with AF of >2 days in duration undergoing clinically indicated TEE. On TEE, the LAA was evaluated for mild spontaneous echo contrast (SEC), severe SEC, sludge, or thrombus. Doppler Tissue imaging (DTI) peak S-wave and E-wave velocities of the LAA walls (anterior, posterior, and apical) were acquired on TTE. Transthoracic echocardiographic harmonic imaging (with and without intravenous contrast) was examined to determine its ability to identify LAA SEC, sludge, or thrombus. Results: Among the 118 patients, TEE identified 6 (5%) with LAA sludge and 2 (2%) with LAA thrombi. Both LAA thrombi were identified on TTE using harmonic imaging with contrast. Anterior, posterior, and apical LAA wall DTI velocities on TTE varied significantly among the 3 groups examined (no SEC, mild SEC, severe SEC, sludge or thrombus). An apical E velocity ≤ 9.7 cm/s on TTE best identified the group of patients with severe SEC, sludge, or thrombus. An anterior S velocity ≤ 5.2 cm/s on TTE best identified the group of patients with sludge or thrombus. Conclusions: The CLOTS multicenter pilot trial determined that TTE is useful in the detection of thrombus using harmonic imaging combined with intravenous contrast (Optison; GE Healthcare, Milwaukee, WI). Additionally, LAA wall DTI velocities on TTE are useful in determining the severity of LAA SEC and detecting sludge or thrombus.

Original languageEnglish (US)
Pages (from-to)1165-1172
Number of pages8
JournalJournal of the American Society of Echocardiography
Volume22
Issue number10
DOIs
StatePublished - Oct 2009

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Atrial Appendage
Multicenter Studies
Echocardiography
Thrombosis
Sewage
Transesophageal Echocardiography
Atrial Fibrillation

Keywords

  • Atrial fibrillation
  • Doppler tissue imaging
  • Left atrial appendage
  • Spontaneous echo contrast
  • Thrombus

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Cardiology and Cardiovascular Medicine

Cite this

Comprehensive Left Atrial Appendage Optimization of Thrombus Using Surface Echocardiography : The CLOTS Multicenter Pilot Trial. / Sallach, John A.; Puwanant, Sarinya; Drinko, Jeanne K.; Jaffer, Sukaina; Donal, Erwan; Thambidorai, Senthil K.; Asher, Craig R.; Jaber, Wael A.; Stoddard, Marcus F.; Zoghbi, William A.; Weissmann, Neil J.; Mulvagh, Sharon L.; Malouf, Joseph F.; Jasper, Susan E.; Borowski, Allen G.; Apperson-Hansen, Carolyn; Lieber, Elizabeth A.; Li, Jianbo; Klein, Allan L.

In: Journal of the American Society of Echocardiography, Vol. 22, No. 10, 10.2009, p. 1165-1172.

Research output: Contribution to journalArticle

Sallach, JA, Puwanant, S, Drinko, JK, Jaffer, S, Donal, E, Thambidorai, SK, Asher, CR, Jaber, WA, Stoddard, MF, Zoghbi, WA, Weissmann, NJ, Mulvagh, SL, Malouf, JF, Jasper, SE, Borowski, AG, Apperson-Hansen, C, Lieber, EA, Li, J & Klein, AL 2009, 'Comprehensive Left Atrial Appendage Optimization of Thrombus Using Surface Echocardiography: The CLOTS Multicenter Pilot Trial', Journal of the American Society of Echocardiography, vol. 22, no. 10, pp. 1165-1172. https://doi.org/10.1016/j.echo.2009.05.028
Sallach, John A. ; Puwanant, Sarinya ; Drinko, Jeanne K. ; Jaffer, Sukaina ; Donal, Erwan ; Thambidorai, Senthil K. ; Asher, Craig R. ; Jaber, Wael A. ; Stoddard, Marcus F. ; Zoghbi, William A. ; Weissmann, Neil J. ; Mulvagh, Sharon L. ; Malouf, Joseph F. ; Jasper, Susan E. ; Borowski, Allen G. ; Apperson-Hansen, Carolyn ; Lieber, Elizabeth A. ; Li, Jianbo ; Klein, Allan L. / Comprehensive Left Atrial Appendage Optimization of Thrombus Using Surface Echocardiography : The CLOTS Multicenter Pilot Trial. In: Journal of the American Society of Echocardiography. 2009 ; Vol. 22, No. 10. pp. 1165-1172.
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abstract = "Background: The aim of this study was to determine the ability to identify thrombus within the left atrial appendage (LAA) in the setting of atrial fibrillation (AF) using transthoracic echocardiography (TTE). In AF, the structure and function of the LAA has historically been evaluated using transesophageal echocardiography (TEE). The role of TTE remains undefined. Methods: The Comprehensive Left Atrial Appendage Optimization of Thrombus (CLOTS) multicenter study enrolled 118 patients (85 men; mean age, 67 ± 13 years) with AF of >2 days in duration undergoing clinically indicated TEE. On TEE, the LAA was evaluated for mild spontaneous echo contrast (SEC), severe SEC, sludge, or thrombus. Doppler Tissue imaging (DTI) peak S-wave and E-wave velocities of the LAA walls (anterior, posterior, and apical) were acquired on TTE. Transthoracic echocardiographic harmonic imaging (with and without intravenous contrast) was examined to determine its ability to identify LAA SEC, sludge, or thrombus. Results: Among the 118 patients, TEE identified 6 (5{\%}) with LAA sludge and 2 (2{\%}) with LAA thrombi. Both LAA thrombi were identified on TTE using harmonic imaging with contrast. Anterior, posterior, and apical LAA wall DTI velocities on TTE varied significantly among the 3 groups examined (no SEC, mild SEC, severe SEC, sludge or thrombus). An apical E velocity ≤ 9.7 cm/s on TTE best identified the group of patients with severe SEC, sludge, or thrombus. An anterior S velocity ≤ 5.2 cm/s on TTE best identified the group of patients with sludge or thrombus. Conclusions: The CLOTS multicenter pilot trial determined that TTE is useful in the detection of thrombus using harmonic imaging combined with intravenous contrast (Optison; GE Healthcare, Milwaukee, WI). Additionally, LAA wall DTI velocities on TTE are useful in determining the severity of LAA SEC and detecting sludge or thrombus.",
keywords = "Atrial fibrillation, Doppler tissue imaging, Left atrial appendage, Spontaneous echo contrast, Thrombus",
author = "Sallach, {John A.} and Sarinya Puwanant and Drinko, {Jeanne K.} and Sukaina Jaffer and Erwan Donal and Thambidorai, {Senthil K.} and Asher, {Craig R.} and Jaber, {Wael A.} and Stoddard, {Marcus F.} and Zoghbi, {William A.} and Weissmann, {Neil J.} and Mulvagh, {Sharon L.} and Malouf, {Joseph F.} and Jasper, {Susan E.} and Borowski, {Allen G.} and Carolyn Apperson-Hansen and Lieber, {Elizabeth A.} and Jianbo Li and Klein, {Allan L.}",
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T1 - Comprehensive Left Atrial Appendage Optimization of Thrombus Using Surface Echocardiography

T2 - The CLOTS Multicenter Pilot Trial

AU - Sallach, John A.

AU - Puwanant, Sarinya

AU - Drinko, Jeanne K.

AU - Jaffer, Sukaina

AU - Donal, Erwan

AU - Thambidorai, Senthil K.

AU - Asher, Craig R.

AU - Jaber, Wael A.

AU - Stoddard, Marcus F.

AU - Zoghbi, William A.

AU - Weissmann, Neil J.

AU - Mulvagh, Sharon L.

AU - Malouf, Joseph F.

AU - Jasper, Susan E.

AU - Borowski, Allen G.

AU - Apperson-Hansen, Carolyn

AU - Lieber, Elizabeth A.

AU - Li, Jianbo

AU - Klein, Allan L.

PY - 2009/10

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N2 - Background: The aim of this study was to determine the ability to identify thrombus within the left atrial appendage (LAA) in the setting of atrial fibrillation (AF) using transthoracic echocardiography (TTE). In AF, the structure and function of the LAA has historically been evaluated using transesophageal echocardiography (TEE). The role of TTE remains undefined. Methods: The Comprehensive Left Atrial Appendage Optimization of Thrombus (CLOTS) multicenter study enrolled 118 patients (85 men; mean age, 67 ± 13 years) with AF of >2 days in duration undergoing clinically indicated TEE. On TEE, the LAA was evaluated for mild spontaneous echo contrast (SEC), severe SEC, sludge, or thrombus. Doppler Tissue imaging (DTI) peak S-wave and E-wave velocities of the LAA walls (anterior, posterior, and apical) were acquired on TTE. Transthoracic echocardiographic harmonic imaging (with and without intravenous contrast) was examined to determine its ability to identify LAA SEC, sludge, or thrombus. Results: Among the 118 patients, TEE identified 6 (5%) with LAA sludge and 2 (2%) with LAA thrombi. Both LAA thrombi were identified on TTE using harmonic imaging with contrast. Anterior, posterior, and apical LAA wall DTI velocities on TTE varied significantly among the 3 groups examined (no SEC, mild SEC, severe SEC, sludge or thrombus). An apical E velocity ≤ 9.7 cm/s on TTE best identified the group of patients with severe SEC, sludge, or thrombus. An anterior S velocity ≤ 5.2 cm/s on TTE best identified the group of patients with sludge or thrombus. Conclusions: The CLOTS multicenter pilot trial determined that TTE is useful in the detection of thrombus using harmonic imaging combined with intravenous contrast (Optison; GE Healthcare, Milwaukee, WI). Additionally, LAA wall DTI velocities on TTE are useful in determining the severity of LAA SEC and detecting sludge or thrombus.

AB - Background: The aim of this study was to determine the ability to identify thrombus within the left atrial appendage (LAA) in the setting of atrial fibrillation (AF) using transthoracic echocardiography (TTE). In AF, the structure and function of the LAA has historically been evaluated using transesophageal echocardiography (TEE). The role of TTE remains undefined. Methods: The Comprehensive Left Atrial Appendage Optimization of Thrombus (CLOTS) multicenter study enrolled 118 patients (85 men; mean age, 67 ± 13 years) with AF of >2 days in duration undergoing clinically indicated TEE. On TEE, the LAA was evaluated for mild spontaneous echo contrast (SEC), severe SEC, sludge, or thrombus. Doppler Tissue imaging (DTI) peak S-wave and E-wave velocities of the LAA walls (anterior, posterior, and apical) were acquired on TTE. Transthoracic echocardiographic harmonic imaging (with and without intravenous contrast) was examined to determine its ability to identify LAA SEC, sludge, or thrombus. Results: Among the 118 patients, TEE identified 6 (5%) with LAA sludge and 2 (2%) with LAA thrombi. Both LAA thrombi were identified on TTE using harmonic imaging with contrast. Anterior, posterior, and apical LAA wall DTI velocities on TTE varied significantly among the 3 groups examined (no SEC, mild SEC, severe SEC, sludge or thrombus). An apical E velocity ≤ 9.7 cm/s on TTE best identified the group of patients with severe SEC, sludge, or thrombus. An anterior S velocity ≤ 5.2 cm/s on TTE best identified the group of patients with sludge or thrombus. Conclusions: The CLOTS multicenter pilot trial determined that TTE is useful in the detection of thrombus using harmonic imaging combined with intravenous contrast (Optison; GE Healthcare, Milwaukee, WI). Additionally, LAA wall DTI velocities on TTE are useful in determining the severity of LAA SEC and detecting sludge or thrombus.

KW - Atrial fibrillation

KW - Doppler tissue imaging

KW - Left atrial appendage

KW - Spontaneous echo contrast

KW - Thrombus

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