Abstract
Objectives: This study aims to establish parameters for identifying normal function for each of the 3 iterations of balloon-expandable valves and 2 iterations of self-expanding valves. Background: Expected transthoracic echocardiographic Doppler-derived hemodynamic data for transcatheter aortic valves inform pre-implant decision-making and post-implanted monitoring of longitudinal valve function. Methods: We collected the Echocardiography Core Lab measured mean gradients and effective orifice area (EOA) from discharge or 30-day echocardiograms from randomized trials; the PARTNER (Placement of Aortic Transcatheter Valves) trials for the balloon-expandable valves and the Medtronic CoreValve US Pivotal trial and Medtronic CoreValve Evolut R United States IDE Clinical Study for the self-expanding valves. Results: For all SAPIEN (Edwards Lifesciences, Irvine, California) valve sizes, mean EOA = 1.70 ± 0.49 cm2 with mean gradient of 9.36 ± 4.13 mm Hg. For all SAPIEN XT valve sizes, mean EOA = 1.67 ± 0.46 cm2 with mean gradient of 9.52 ± 3.64 mm Hg. For all SAPIEN 3 valve sizes, the mean EOA = 1.66 ± 0.38 cm2 with mean gradient of 11.18 ± 4.35 mm Hg. For all CoreValve valve sizes, the mean EOA = 1.88 ± 0.56 cm2 with mean gradient of 8.85 ± 4.14 mm Hg. For all Evolut R valve sizes, the mean EOA = 2.01 ± 0.65 cm2 with mean gradient of 7.52 ± 3.19 mm Hg. The SAPIEN 3 post-implant EOA was progressively larger for each quintile of baseline annular area by computed tomography (p < 0.001). Similarly, for the Evolut R valve, post-implantation EOA was significantly larger for each quintile of baseline annular perimeter (p < 0.001). Conclusions: Tables of expected mean transcatheter aortic valve hemodynamics by valve type and size are essential in evaluating the function of these transcatheter prosthetic valves. Tables of expected EOA by the native annular anatomy may be useful for pre-implantation decision making. Criteria for defining structural valve dysfunction are proposed.
| Original language | English (US) |
|---|---|
| Journal | JACC: Cardiovascular Imaging |
| DOIs | |
| State | Accepted/In press - Jan 1 2018 |
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Keywords
- echocardiography
- effective orifice area
- hemodynamics
- transcatheter aortic valve replacement
ASJC Scopus subject areas
- Radiology Nuclear Medicine and imaging
- Cardiology and Cardiovascular Medicine
Cite this
Comprehensive Echocardiographic Assessment of Normal Transcatheter Valve Function. / Hahn, Rebecca T.; Leipsic, Jonathon; Douglas, Pamela S.; Jaber, Wael A.; Weissman, Neil J.; Pibarot, Philippe; Blanke, Philipp; Oh, Jae Kuen.
In: JACC: Cardiovascular Imaging, 01.01.2018.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Comprehensive Echocardiographic Assessment of Normal Transcatheter Valve Function
AU - Hahn, Rebecca T.
AU - Leipsic, Jonathon
AU - Douglas, Pamela S.
AU - Jaber, Wael A.
AU - Weissman, Neil J.
AU - Pibarot, Philippe
AU - Blanke, Philipp
AU - Oh, Jae Kuen
PY - 2018/1/1
Y1 - 2018/1/1
N2 - Objectives: This study aims to establish parameters for identifying normal function for each of the 3 iterations of balloon-expandable valves and 2 iterations of self-expanding valves. Background: Expected transthoracic echocardiographic Doppler-derived hemodynamic data for transcatheter aortic valves inform pre-implant decision-making and post-implanted monitoring of longitudinal valve function. Methods: We collected the Echocardiography Core Lab measured mean gradients and effective orifice area (EOA) from discharge or 30-day echocardiograms from randomized trials; the PARTNER (Placement of Aortic Transcatheter Valves) trials for the balloon-expandable valves and the Medtronic CoreValve US Pivotal trial and Medtronic CoreValve Evolut R United States IDE Clinical Study for the self-expanding valves. Results: For all SAPIEN (Edwards Lifesciences, Irvine, California) valve sizes, mean EOA = 1.70 ± 0.49 cm2 with mean gradient of 9.36 ± 4.13 mm Hg. For all SAPIEN XT valve sizes, mean EOA = 1.67 ± 0.46 cm2 with mean gradient of 9.52 ± 3.64 mm Hg. For all SAPIEN 3 valve sizes, the mean EOA = 1.66 ± 0.38 cm2 with mean gradient of 11.18 ± 4.35 mm Hg. For all CoreValve valve sizes, the mean EOA = 1.88 ± 0.56 cm2 with mean gradient of 8.85 ± 4.14 mm Hg. For all Evolut R valve sizes, the mean EOA = 2.01 ± 0.65 cm2 with mean gradient of 7.52 ± 3.19 mm Hg. The SAPIEN 3 post-implant EOA was progressively larger for each quintile of baseline annular area by computed tomography (p < 0.001). Similarly, for the Evolut R valve, post-implantation EOA was significantly larger for each quintile of baseline annular perimeter (p < 0.001). Conclusions: Tables of expected mean transcatheter aortic valve hemodynamics by valve type and size are essential in evaluating the function of these transcatheter prosthetic valves. Tables of expected EOA by the native annular anatomy may be useful for pre-implantation decision making. Criteria for defining structural valve dysfunction are proposed.
AB - Objectives: This study aims to establish parameters for identifying normal function for each of the 3 iterations of balloon-expandable valves and 2 iterations of self-expanding valves. Background: Expected transthoracic echocardiographic Doppler-derived hemodynamic data for transcatheter aortic valves inform pre-implant decision-making and post-implanted monitoring of longitudinal valve function. Methods: We collected the Echocardiography Core Lab measured mean gradients and effective orifice area (EOA) from discharge or 30-day echocardiograms from randomized trials; the PARTNER (Placement of Aortic Transcatheter Valves) trials for the balloon-expandable valves and the Medtronic CoreValve US Pivotal trial and Medtronic CoreValve Evolut R United States IDE Clinical Study for the self-expanding valves. Results: For all SAPIEN (Edwards Lifesciences, Irvine, California) valve sizes, mean EOA = 1.70 ± 0.49 cm2 with mean gradient of 9.36 ± 4.13 mm Hg. For all SAPIEN XT valve sizes, mean EOA = 1.67 ± 0.46 cm2 with mean gradient of 9.52 ± 3.64 mm Hg. For all SAPIEN 3 valve sizes, the mean EOA = 1.66 ± 0.38 cm2 with mean gradient of 11.18 ± 4.35 mm Hg. For all CoreValve valve sizes, the mean EOA = 1.88 ± 0.56 cm2 with mean gradient of 8.85 ± 4.14 mm Hg. For all Evolut R valve sizes, the mean EOA = 2.01 ± 0.65 cm2 with mean gradient of 7.52 ± 3.19 mm Hg. The SAPIEN 3 post-implant EOA was progressively larger for each quintile of baseline annular area by computed tomography (p < 0.001). Similarly, for the Evolut R valve, post-implantation EOA was significantly larger for each quintile of baseline annular perimeter (p < 0.001). Conclusions: Tables of expected mean transcatheter aortic valve hemodynamics by valve type and size are essential in evaluating the function of these transcatheter prosthetic valves. Tables of expected EOA by the native annular anatomy may be useful for pre-implantation decision making. Criteria for defining structural valve dysfunction are proposed.
KW - echocardiography
KW - effective orifice area
KW - hemodynamics
KW - transcatheter aortic valve replacement
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UR - http://www.scopus.com/inward/citedby.url?scp=85048566445&partnerID=8YFLogxK
U2 - 10.1016/j.jcmg.2018.04.010
DO - 10.1016/j.jcmg.2018.04.010
M3 - Article
C2 - 29909110
AN - SCOPUS:85048566445
JO - JACC: Cardiovascular Imaging
JF - JACC: Cardiovascular Imaging
SN - 1936-878X
ER -