Comprehensive analysis of human leukocyte antigen class I alleles and cervical neoplasia in 3 epidemiologic studies

Sophia S. Wang; Allan Hildesheim; Xiaojiang Gao; Mark Schiffman; Rolando Herrero; M. Concepcion Bratti; Mark E. Sherman; Willard A. Barnes; Mitchell D. Greenberg; Larry Mc Gowan; Rodrigue Mortel; Peter E. Schwartz; Richard J. Zaino; Andrew G. Glass; Robert D. Burk; Peter Karacki; Mary Carrington

doi:10.1086/342295

Comprehensive analysis of human leukocyte antigen class I alleles and cervical neoplasia in 3 epidemiologic studies

Sophia S. Wang, Allan Hildesheim, Xiaojiang Gao, Mark Schiffman, Rolando Herrero, M. Concepcion Bratti, Mark E. Sherman, Willard A. Barnes, Mitchell D. Greenberg, Larry Mc Gowan, Rodrigue Mortel, Peter E. Schwartz, Richard J. Zaino, Andrew G. Glass, Robert D. Burk, Peter Karacki, Mary Carrington

Quantitative Health Sciences

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Abstract

To comprehensively explore the relationship between human leukocyte antigen (HLA) class I alleles and cervical neoplasia, a subset of participants from 3 large US and Costa Rican cervix studies were typed for HLA class I alleles. Study subjects were women with cervical cancer or high-grade squamous epithelial lesions (HSILs; n = 365) or low-grade squamous epithelial lesions (LSILs; n = 275) or who were cytologically normal (control subjects; n = 681). Allele-disease associations were assessed by logistic regression analysis. Consistent associations across all studies were observed for HLA-CW*0202 with a combined odds ratio of 0.53 (95% confidence interval [CI], 0.29-0.89) for cancer or HSILs and 0.58 (95% CI, 0.37-1.04) for LSILs, compared with control subjects and adjusted for study. This finding supports the hypothesis that a single allele may be sufficient to confer protection against cervical neoplasia. Given the relationship between HLA-C and its receptors on natural killer (NK) cells, a role is proposed for NK function in human papillomavirus infection and cervical neoplasia.

Original language	English (US)
Pages (from-to)	598-605
Number of pages	8
Journal	Journal of Infectious Diseases
Volume	186
Issue number	5
DOIs	https://doi.org/10.1086/342295
State	Published - Sep 1 2002

ASJC Scopus subject areas

General Medicine

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Wang, S. S., Hildesheim, A., Gao, X., Schiffman, M., Herrero, R., Bratti, M. C., Sherman, M. E., Barnes, W. A., Greenberg, M. D., Mc Gowan, L., Mortel, R., Schwartz, P. E., Zaino, R. J., Glass, A. G., Burk, R. D., Karacki, P., & Carrington, M. (2002). Comprehensive analysis of human leukocyte antigen class I alleles and cervical neoplasia in 3 epidemiologic studies. Journal of Infectious Diseases, 186(5), 598-605. https://doi.org/10.1086/342295

Wang, SS, Hildesheim, A, Gao, X, Schiffman, M, Herrero, R, Bratti, MC, Sherman, ME, Barnes, WA, Greenberg, MD, Mc Gowan, L, Mortel, R, Schwartz, PE, Zaino, RJ, Glass, AG, Burk, RD, Karacki, P & Carrington, M 2002, 'Comprehensive analysis of human leukocyte antigen class I alleles and cervical neoplasia in 3 epidemiologic studies', Journal of Infectious Diseases, vol. 186, no. 5, pp. 598-605. https://doi.org/10.1086/342295

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title = "Comprehensive analysis of human leukocyte antigen class I alleles and cervical neoplasia in 3 epidemiologic studies",

abstract = "To comprehensively explore the relationship between human leukocyte antigen (HLA) class I alleles and cervical neoplasia, a subset of participants from 3 large US and Costa Rican cervix studies were typed for HLA class I alleles. Study subjects were women with cervical cancer or high-grade squamous epithelial lesions (HSILs; n = 365) or low-grade squamous epithelial lesions (LSILs; n = 275) or who were cytologically normal (control subjects; n = 681). Allele-disease associations were assessed by logistic regression analysis. Consistent associations across all studies were observed for HLA-CW*0202 with a combined odds ratio of 0.53 (95% confidence interval [CI], 0.29-0.89) for cancer or HSILs and 0.58 (95% CI, 0.37-1.04) for LSILs, compared with control subjects and adjusted for study. This finding supports the hypothesis that a single allele may be sufficient to confer protection against cervical neoplasia. Given the relationship between HLA-C and its receptors on natural killer (NK) cells, a role is proposed for NK function in human papillomavirus infection and cervical neoplasia.",

author = "Wang, {Sophia S.} and Allan Hildesheim and Xiaojiang Gao and Mark Schiffman and Rolando Herrero and Bratti, {M. Concepcion} and Sherman, {Mark E.} and Barnes, {Willard A.} and Greenberg, {Mitchell D.} and {Mc Gowan}, Larry and Rodrigue Mortel and Schwartz, {Peter E.} and Zaino, {Richard J.} and Glass, {Andrew G.} and Burk, {Robert D.} and Peter Karacki and Mary Carrington",

note = "Funding Information: Financial support: National Institutes of Health (contracts CO-12400, CP-21081, and CP-31061; grant CA-78527 to R.D.B.); FUCODOCSA (Costa Rican Foundation for Training in Health Sciences); Caja Costarri-cense de Seguro Social (Costa Rica).",

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doi = "10.1086/342295",

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T1 - Comprehensive analysis of human leukocyte antigen class I alleles and cervical neoplasia in 3 epidemiologic studies

AU - Wang, Sophia S.

AU - Hildesheim, Allan

AU - Gao, Xiaojiang

AU - Schiffman, Mark

AU - Herrero, Rolando

AU - Bratti, M. Concepcion

AU - Sherman, Mark E.

AU - Barnes, Willard A.

AU - Greenberg, Mitchell D.

AU - Mc Gowan, Larry

AU - Mortel, Rodrigue

AU - Schwartz, Peter E.

AU - Zaino, Richard J.

AU - Glass, Andrew G.

AU - Burk, Robert D.

AU - Karacki, Peter

AU - Carrington, Mary

N1 - Funding Information: Financial support: National Institutes of Health (contracts CO-12400, CP-21081, and CP-31061; grant CA-78527 to R.D.B.); FUCODOCSA (Costa Rican Foundation for Training in Health Sciences); Caja Costarri-cense de Seguro Social (Costa Rica).

PY - 2002/9/1

Y1 - 2002/9/1

N2 - To comprehensively explore the relationship between human leukocyte antigen (HLA) class I alleles and cervical neoplasia, a subset of participants from 3 large US and Costa Rican cervix studies were typed for HLA class I alleles. Study subjects were women with cervical cancer or high-grade squamous epithelial lesions (HSILs; n = 365) or low-grade squamous epithelial lesions (LSILs; n = 275) or who were cytologically normal (control subjects; n = 681). Allele-disease associations were assessed by logistic regression analysis. Consistent associations across all studies were observed for HLA-CW*0202 with a combined odds ratio of 0.53 (95% confidence interval [CI], 0.29-0.89) for cancer or HSILs and 0.58 (95% CI, 0.37-1.04) for LSILs, compared with control subjects and adjusted for study. This finding supports the hypothesis that a single allele may be sufficient to confer protection against cervical neoplasia. Given the relationship between HLA-C and its receptors on natural killer (NK) cells, a role is proposed for NK function in human papillomavirus infection and cervical neoplasia.

AB - To comprehensively explore the relationship between human leukocyte antigen (HLA) class I alleles and cervical neoplasia, a subset of participants from 3 large US and Costa Rican cervix studies were typed for HLA class I alleles. Study subjects were women with cervical cancer or high-grade squamous epithelial lesions (HSILs; n = 365) or low-grade squamous epithelial lesions (LSILs; n = 275) or who were cytologically normal (control subjects; n = 681). Allele-disease associations were assessed by logistic regression analysis. Consistent associations across all studies were observed for HLA-CW*0202 with a combined odds ratio of 0.53 (95% confidence interval [CI], 0.29-0.89) for cancer or HSILs and 0.58 (95% CI, 0.37-1.04) for LSILs, compared with control subjects and adjusted for study. This finding supports the hypothesis that a single allele may be sufficient to confer protection against cervical neoplasia. Given the relationship between HLA-C and its receptors on natural killer (NK) cells, a role is proposed for NK function in human papillomavirus infection and cervical neoplasia.

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Comprehensive analysis of human leukocyte antigen class I alleles and cervical neoplasia in 3 epidemiologic studies

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