Compound muscle action potential duration in critical illness neuromyopathy

Christopher L. Kramer, Andrea J. Boon, C. Michel Harper, Brent P. Goodman

Research output: Contribution to journalArticlepeer-review

7 Scopus citations


Introduction: We sought to determine the specificity of compound muscle action potential (CMAP) durations and amplitudes in a large critical illness neuromyopathy (CINM) cohort relative to controls with other neuromuscular conditions. Methods: Fifty-eight patients with CINM who had been seen over a 17-year period were retrospectively studied. Electrodiagnostic findings of the CINM cohort were compared with patients with axonal peripheral neuropathy and myopathy due to other causes. Results: Mean CMAP durations were prolonged, and mean CMAP amplitudes were severely reduced both proximally and distally in all nerves studied in the CINM cohort relative to the control groups. The specificity of prolonged CMAP durations for CINM approached 100% if they were encountered in more than 1 nerve. Discussion: Prolonged, low-amplitude CMAPs occur more frequently and with greater severity in CINM patients than in neuromuscular controls with myopathy and axonal neuropathy and are highly specific for the diagnosis of CINM. Muscle Nerve 57: 395–400, 2018.

Original languageEnglish (US)
Pages (from-to)395-400
Number of pages6
JournalMuscle and Nerve
Issue number3
StatePublished - Mar 2018


  • ICU acquired weakness
  • compound muscle action potential amplitude
  • compound muscle action potential duration
  • critical illness myopathy
  • critical illness neuromyopathy
  • critical illness neuropathy
  • nerve conduction study

ASJC Scopus subject areas

  • Physiology
  • Clinical Neurology
  • Cellular and Molecular Neuroscience
  • Physiology (medical)


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