Compound Heterozygosity of Dominant and Recessive COL7A Alleles in a Severely Affected Patient with a Family History of Dystrophic Epidermolysis Bullosa: Clinical Findings, Genetic Testing, and Treatment Implications

Kendra D. Watson, Jennifer J. Schoch, Geoffrey J. Beek, Jennifer L. Hand

Research output: Contribution to journalArticle

1 Scopus citations

Abstract

An 8-year-old girl born to a family with more than three generations of dominant dystrophic epidermolysis bullosa (DDEB) presented with life-threatening confluent skin erosions, mitten hand deformity, and failure to thrive. Reassessment of her family history and genetic testing showed compound heterozygous COL7A mutations, one inherited from her DDEB-affected mother and one from her unaffected, healthy father. This family illustrates the risk of unexpected, severe, autosomal recessive epidermolysis bullosa (EB) in a family with milder, multigenerational autosomal dominant EB. Clinicians should recognize the clinical spectrum of dystrophic EB and recommend genetic consultation when the phenotype conflicts with family history.

Original languageEnglish (US)
Pages (from-to)166-171
Number of pages6
JournalPediatric Dermatology
Volume34
Issue number2
DOIs
StatePublished - Mar 1 2017

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Dermatology

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