Composite outcomes in 2.25-mm drug eluting stents: A systematic review

Justin Z. Lee, Nirmal Singh, Gilbert Ortega, See Wei Low, Uday Kanakadandi, F. David Fortuin, Tom Lassar, Kwan S. Lee

Research output: Contribution to journalArticle

2 Scopus citations

Abstract

Background: Coronary atherosclerosis often involves small-caliber coronaries, yet the safety and efficacy of 2.25-mm DES have been poorly defined, with a general lack of separation of 2.25 with 2.5-mm performance. No randomized head-to-head 2.25. mm DES studies have been reported. There are several single-arm prospective studies, and we aim to systematically review all published specific 2.25-mm data to estimate composite DES-specific performance and highlight current knowledge gaps. Methods: We performed a systematic literature search of PubMed, EMBASE, Web of Science and Cochrane database for clinical trials of 2.25-mm DES. Angiographic and composite clinical outcomes were compared with descriptive statistics. Results: 2.25. mm-Paclitaxel (PES), sirolimus (SES), everolimus (EES) and platinum chromium EES DES-specific outcomes have been reported. Death at 12. months for SES, PES, EES and platinum chromium EES was 1.3%, 3.0%, 1.5%, and 4.4%. Rates of target vessel revascularization at 12. months for SES, PES, EES and platinum chromium EES were 5.7%, 13.3%, 8.8%, and 3.3%. Angiographic outcomes at 9. months to one year were as follows: mean late lumen loss (LLL) for SES, PES, and EES was 0.15. ±. 0.11-mm, 0.28. ±. 0.11-mm, and 0.16. ±. 0.41-mm and mean diameter restenosis for SES, PES, and EES were 29.5. ±. 6.2%, 34.7. ±. 4.2%, and 20.9. ±. 22.5%. Reported stent thrombosis rates for 2.25-mm DES were low ranging from 0% to 2.2% in up to 24-months of follow-up. Conclusions: This systematic review summarizes and tabulates all available specific data on 2.25-mm DES. Based on our descriptive analysis, 2.25-mm DESs have a favorable safety and efficacy profile for the treatment of very small coronary lesions.

Original languageEnglish (US)
Pages (from-to)237-242
Number of pages6
JournalCardiovascular Revascularization Medicine
Volume16
Issue number4
DOIs
StatePublished - Jun 1 2015

Keywords

  • 2.25-mm
  • Drug eluting stents
  • Small coronary vessels

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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    Lee, J. Z., Singh, N., Ortega, G., Low, S. W., Kanakadandi, U., Fortuin, F. D., Lassar, T., & Lee, K. S. (2015). Composite outcomes in 2.25-mm drug eluting stents: A systematic review. Cardiovascular Revascularization Medicine, 16(4), 237-242. https://doi.org/10.1016/j.carrev.2015.03.008