Composite metric R2 − R (1/T2 − 1/T) as a potential MR imaging biomarker associated with changes in pain after ACL reconstruction: A six-month follow-up

AF-ACL Consortium, Matthew A. Frick, Aaron J. Krych

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

This study looked to investigate a new quantitative metric, R2 − R (1/T2 − 1/T), using magnetic resonance (MR) images and voxel-based relaxometry (VBR) for detecting early cartilage degeneration and explore the association with patient-reported outcomes measures (PROMs) in patients 6 months after ACL reconstruction. Sixty-four patients from three sites were bilaterally scanned on a 3T MR with a combined T/T2 protocol to calculate R (1/T) and R2 (1/T2) values at baseline and 6 months after reconstructive surgery. Non-rigid registration was applied to align images onto a template, allowing VBR to determine VBR rate differences and explore cross-sectional and longitudinal differences between injured and uninjured knees, generating Statistical Parametric Maps (SPMs). Baseline R2 − R differences were further correlated with change in PROMs from the Knee Injury and Osteoarthritis Outcome Score (KOOS) from baseline to 6 months. Cross-sectional results demonstrated low relaxation rate differences in the injured patella (baseline: 21%, p = 0.01; 6-months: 18%, p = 0.02), lateral tibia (baseline: 25%, p = 0.01; 6-months: 24%, p = 0.01), and weight-bearing regions of the tibia and femur. The uninjured patella showed significant longitudinal changes (17%, p = 0.02). R2 − R differences showed significant correlations with KOOS PROMs, particularly in the lateral tibia, patella, and trochlea. R2 − R difference VBR analyses provide new and highly sensitive parameters for assessing early cartilage degeneration in patients after ACL injury by integrating findings from both T and T2, commonly used relaxation time parameters, into a single metric.

Original languageEnglish (US)
Pages (from-to)718-729
Number of pages12
JournalJournal of Orthopaedic Research
Volume35
Issue number3
DOIs
StatePublished - Mar 1 2017

Fingerprint

Patella
Tibia
Knee Injuries
Knee Osteoarthritis
Biomarkers
Magnetic Resonance Imaging
Pain
Cartilage
Reconstructive Surgical Procedures
Magnetic Resonance Spectroscopy
Weight-Bearing
Femur
Knee
Patient Reported Outcome Measures

Keywords

  • ACL injury
  • cartilage degeneration
  • KOOS
  • R – R
  • voxel-based relaxometry

ASJC Scopus subject areas

  • Orthopedics and Sports Medicine

Cite this

Composite metric R2 − R (1/T2 − 1/T) as a potential MR imaging biomarker associated with changes in pain after ACL reconstruction : A six-month follow-up. / AF-ACL Consortium; Frick, Matthew A.; Krych, Aaron J.

In: Journal of Orthopaedic Research, Vol. 35, No. 3, 01.03.2017, p. 718-729.

Research output: Contribution to journalArticle

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title = "Composite metric R2 − R1ρ (1/T2 − 1/T1ρ) as a potential MR imaging biomarker associated with changes in pain after ACL reconstruction: A six-month follow-up",
abstract = "This study looked to investigate a new quantitative metric, R2 − R1ρ (1/T2 − 1/T1ρ), using magnetic resonance (MR) images and voxel-based relaxometry (VBR) for detecting early cartilage degeneration and explore the association with patient-reported outcomes measures (PROMs) in patients 6 months after ACL reconstruction. Sixty-four patients from three sites were bilaterally scanned on a 3T MR with a combined T1ρ/T2 protocol to calculate R1ρ (1/T1ρ) and R2 (1/T2) values at baseline and 6 months after reconstructive surgery. Non-rigid registration was applied to align images onto a template, allowing VBR to determine VBR rate differences and explore cross-sectional and longitudinal differences between injured and uninjured knees, generating Statistical Parametric Maps (SPMs). Baseline R2 − R1ρ differences were further correlated with change in PROMs from the Knee Injury and Osteoarthritis Outcome Score (KOOS) from baseline to 6 months. Cross-sectional results demonstrated low relaxation rate differences in the injured patella (baseline: 21{\%}, p = 0.01; 6-months: 18{\%}, p = 0.02), lateral tibia (baseline: 25{\%}, p = 0.01; 6-months: 24{\%}, p = 0.01), and weight-bearing regions of the tibia and femur. The uninjured patella showed significant longitudinal changes (17{\%}, p = 0.02). R2 − R1ρ differences showed significant correlations with KOOS PROMs, particularly in the lateral tibia, patella, and trochlea. R2 − R1ρ difference VBR analyses provide new and highly sensitive parameters for assessing early cartilage degeneration in patients after ACL injury by integrating findings from both T1ρ and T2, commonly used relaxation time parameters, into a single metric.",
keywords = "ACL injury, cartilage degeneration, KOOS, R – R, voxel-based relaxometry",
author = "{AF-ACL Consortium} and Colin Russell and Valentina Pedoia and Sharmila Majumdar and Koff, {Matthew F.} and Goldring, {Steven R.} and Mary Goldring and Hannafin, {Jo A.} and Marx, {Robert G.} and Nawabi, {Danyal H.} and Miguel Otero and Hollis Potter and Rodeo, {Scott A.} and Parina Shah and Warren, {Russell F.} and Amrami, {Kimberley K.} and Frick, {Matthew A.} and Krych, {Aaron J.} and Krych, {Aaron J.} and Aaron Krych and Williams, {Steven L.} and Martin Kretzchmar and Lansdown, {Drew A.} and Alan Li and Xiaojuan Li and Link, {Thomas M.} and {Benjamin Ma}, C. and Narihiro Okazaki and Dragana Savic and Benedikt Schwaiger and Favian Su and Cory Wyatt and Hardin, {John A.}",
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AU - Amrami, Kimberley K.

AU - Frick, Matthew A.

AU - Krych, Aaron J.

AU - Krych, Aaron J.

AU - Krych, Aaron

AU - Williams, Steven L.

AU - Kretzchmar, Martin

AU - Lansdown, Drew A.

AU - Li, Alan

AU - Li, Xiaojuan

AU - Link, Thomas M.

AU - Benjamin Ma, C.

AU - Okazaki, Narihiro

AU - Savic, Dragana

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N2 - This study looked to investigate a new quantitative metric, R2 − R1ρ (1/T2 − 1/T1ρ), using magnetic resonance (MR) images and voxel-based relaxometry (VBR) for detecting early cartilage degeneration and explore the association with patient-reported outcomes measures (PROMs) in patients 6 months after ACL reconstruction. Sixty-four patients from three sites were bilaterally scanned on a 3T MR with a combined T1ρ/T2 protocol to calculate R1ρ (1/T1ρ) and R2 (1/T2) values at baseline and 6 months after reconstructive surgery. Non-rigid registration was applied to align images onto a template, allowing VBR to determine VBR rate differences and explore cross-sectional and longitudinal differences between injured and uninjured knees, generating Statistical Parametric Maps (SPMs). Baseline R2 − R1ρ differences were further correlated with change in PROMs from the Knee Injury and Osteoarthritis Outcome Score (KOOS) from baseline to 6 months. Cross-sectional results demonstrated low relaxation rate differences in the injured patella (baseline: 21%, p = 0.01; 6-months: 18%, p = 0.02), lateral tibia (baseline: 25%, p = 0.01; 6-months: 24%, p = 0.01), and weight-bearing regions of the tibia and femur. The uninjured patella showed significant longitudinal changes (17%, p = 0.02). R2 − R1ρ differences showed significant correlations with KOOS PROMs, particularly in the lateral tibia, patella, and trochlea. R2 − R1ρ difference VBR analyses provide new and highly sensitive parameters for assessing early cartilage degeneration in patients after ACL injury by integrating findings from both T1ρ and T2, commonly used relaxation time parameters, into a single metric.

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KW - KOOS

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KW - voxel-based relaxometry

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