Composite Hodgkin and non-Hodgkin lymphoma of the mitral and aortic valves

Amber D. Khanna; Harold M. Burkhart; Marosh Manduch; Andrew L. Feldman; David J. Inwards; Heidi M. Connolly

doi:10.1016/j.echo.2010.03.011

Composite Hodgkin and non-Hodgkin lymphoma of the mitral and aortic valves

Amber D. Khanna, Harold M. Burkhart, Marosh Manduch, Andrew L. Feldman, David J. Inwards, Heidi M. Connolly

Laboratory Medicine and Pathology

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

A 58-year-old man with a remote history of diffuse large B-cell lymphoma (DLBCL), status post chemotherapy, radiation, and peripheral blood stem cell transplantation, presented with splenic nodular sclerosis classical Hodgkin lymphoma. He was found to have aortic and mitral valve mass lesions. The mitral valve mass showed typical histologic and immunophenotypic features of nodular sclerosis classical Hodgkin lymphoma, whereas the aortic valve mass and aortic mitral curtain tissue showed DLBCL with necrosis. Both tumors were Epstein-Barr virus positive and were clonally related; however, they were not related to his DLBCL from 14 years prior. This is the first case report of a patient with a composite lymphoma affecting two cardiac valves.

Original language	English (US)
Pages (from-to)	1113.e5-1113.e7
Journal	Journal of the American Society of Echocardiography
Volume	23
Issue number	10
DOIs	https://doi.org/10.1016/j.echo.2010.03.011
State	Published - Oct 2010

Keywords

Lymphoma
Mitral valve
Transesophageal echocardiography
Tumor

ASJC Scopus subject areas

Radiology Nuclear Medicine and imaging
Cardiology and Cardiovascular Medicine

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10.1016/j.echo.2010.03.011

Cite this

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title = "Composite Hodgkin and non-Hodgkin lymphoma of the mitral and aortic valves",

abstract = "A 58-year-old man with a remote history of diffuse large B-cell lymphoma (DLBCL), status post chemotherapy, radiation, and peripheral blood stem cell transplantation, presented with splenic nodular sclerosis classical Hodgkin lymphoma. He was found to have aortic and mitral valve mass lesions. The mitral valve mass showed typical histologic and immunophenotypic features of nodular sclerosis classical Hodgkin lymphoma, whereas the aortic valve mass and aortic mitral curtain tissue showed DLBCL with necrosis. Both tumors were Epstein-Barr virus positive and were clonally related; however, they were not related to his DLBCL from 14 years prior. This is the first case report of a patient with a composite lymphoma affecting two cardiac valves.",

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AU - Khanna, Amber D.

AU - Burkhart, Harold M.

AU - Manduch, Marosh

AU - Feldman, Andrew L.

AU - Inwards, David J.

AU - Connolly, Heidi M.

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AB - A 58-year-old man with a remote history of diffuse large B-cell lymphoma (DLBCL), status post chemotherapy, radiation, and peripheral blood stem cell transplantation, presented with splenic nodular sclerosis classical Hodgkin lymphoma. He was found to have aortic and mitral valve mass lesions. The mitral valve mass showed typical histologic and immunophenotypic features of nodular sclerosis classical Hodgkin lymphoma, whereas the aortic valve mass and aortic mitral curtain tissue showed DLBCL with necrosis. Both tumors were Epstein-Barr virus positive and were clonally related; however, they were not related to his DLBCL from 14 years prior. This is the first case report of a patient with a composite lymphoma affecting two cardiac valves.

KW - Lymphoma

KW - Mitral valve

KW - Transesophageal echocardiography

KW - Tumor

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Composite Hodgkin and non-Hodgkin lymphoma of the mitral and aortic valves

Abstract

Keywords

ASJC Scopus subject areas

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