Complications of androgen deprivation therapy: Prevention and treatment

Jeffrey M. Holzbeierlein, Erik P Castle, J. Brantley Thrasher

Research output: Contribution to journalArticle

49 Citations (Scopus)

Abstract

Androgen deprivation, as a form of treatment for prostate cancer, has been used for decades. Within the last decade, however, its use has increased significantly. Therefore, it is incumbent upon the physician to be familiar with the side effects associated with this treatment. Some of these side effects (eg, osteoporosis, changes in lipid profiles, and anemia) may be associated with significant morbidity, whereas others (eg, impotence, decreased libido, fatigue, and hot flashes) primarily affect the patient's quality of life. Prevention strategies and treatments exist for many of these side effects. In addition, alternative forms of antiandrogen therapy such as intermittent hormone ablation and antiandrogen monotherapy may be effective, with the added benefit of minimizing side effects. This review focuses on the wide range of side effects associated with androgen ablation as well aspreventive and treatment strategies.

Original languageEnglish (US)
Pages (from-to)303-309
Number of pages7
JournalOncology
Volume18
Issue number3
StatePublished - Mar 2004
Externally publishedYes

Fingerprint

Androgens
Androgen Antagonists
Hot Flashes
Therapeutics
Libido
Erectile Dysfunction
Osteoporosis
Fatigue
Anemia
Prostatic Neoplasms
Quality of Life
Hormones
Morbidity
Physicians
Lipids

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

Holzbeierlein, J. M., Castle, E. P., & Thrasher, J. B. (2004). Complications of androgen deprivation therapy: Prevention and treatment. Oncology, 18(3), 303-309.

Complications of androgen deprivation therapy : Prevention and treatment. / Holzbeierlein, Jeffrey M.; Castle, Erik P; Thrasher, J. Brantley.

In: Oncology, Vol. 18, No. 3, 03.2004, p. 303-309.

Research output: Contribution to journalArticle

Holzbeierlein, JM, Castle, EP & Thrasher, JB 2004, 'Complications of androgen deprivation therapy: Prevention and treatment', Oncology, vol. 18, no. 3, pp. 303-309.
Holzbeierlein, Jeffrey M. ; Castle, Erik P ; Thrasher, J. Brantley. / Complications of androgen deprivation therapy : Prevention and treatment. In: Oncology. 2004 ; Vol. 18, No. 3. pp. 303-309.
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