Complex-valued stiffness reconstruction for magnetic resonance elastography by algebraic inversion of the differential equation

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Abstract

Noninvasive quantitation of the mechanical properties of tissue could improve early detection of pathology. Previously a method for detecting displacement from propagating shear waves using a phase-contrast MRI technique was developed. In this work it is demonstrated how a collection of data representing the full vector displacement field could be used to potentially estimate the full complex stiffness tensor. An algebraic inversion approach useful for piece-wise homogeneous materials is described in detail for the general isotropic case, which is then specialized to incompressible materials as a model for tissue. Results of the inversion approach are presented for simulated and experimental phantom data that show the technique can be used to obtain shear wave-speed and attenuation in regions where there is sufficient signal-to-noise ratio in the displacement and its second spatial derivatives. The sensitivity to noise is higher in the attenuation estimates than the shear wave-speed estimates.

Original languageEnglish (US)
Pages (from-to)299-310
Number of pages12
JournalMagnetic Resonance in Medicine
Volume45
Issue number2
DOIs
StatePublished - Feb 15 2001

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Keywords

  • Elastography
  • Parameter estimation
  • Phase contrast
  • Shear modulus
  • Tissue characterization

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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