Complete remission of nodular pulmonary Langerhans cell histiocytosis lesions induced by 2-chlorodeoxyadenosine in a non-smoker

Michelle R. Aerni, Marie Christine Aubry, Jeffery L. Myers, Robert Vassallo

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

Pulmonary Langerhans cell histiocytosis (LCH) is an uncommon cause of interstitial lung disease. Corticosteroids and chemotherapeutic agents are frequently used to treat symptomatic patients but their efficacy is unclear. We describe a 66-year-old with biopsy-proven pulmonary and systemic LCH, whose pulmonary abnormalities responded dramatically to treatment with 2-chlorodeoxyadenosine (2-CdA). We propose that, in selected cases, 2-CdA should be considered in the management of pulmonary LCH.

Original languageEnglish (US)
Pages (from-to)316-319
Number of pages4
JournalRespiratory Medicine
Volume102
Issue number2
DOIs
StatePublished - Feb 2008

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Cladribine
Langerhans Cell Histiocytosis
Lung
Interstitial Lung Diseases
Adrenal Cortex Hormones
Biopsy

Keywords

  • 2-Chlorodeoxyadenosine
  • Cigarette smoking
  • Interstitial lung disease
  • Langerhans cell histiocytosis
  • Lung nodules

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

Cite this

Complete remission of nodular pulmonary Langerhans cell histiocytosis lesions induced by 2-chlorodeoxyadenosine in a non-smoker. / Aerni, Michelle R.; Christine Aubry, Marie; Myers, Jeffery L.; Vassallo, Robert.

In: Respiratory Medicine, Vol. 102, No. 2, 02.2008, p. 316-319.

Research output: Contribution to journalArticle

Aerni, Michelle R. ; Christine Aubry, Marie ; Myers, Jeffery L. ; Vassallo, Robert. / Complete remission of nodular pulmonary Langerhans cell histiocytosis lesions induced by 2-chlorodeoxyadenosine in a non-smoker. In: Respiratory Medicine. 2008 ; Vol. 102, No. 2. pp. 316-319.
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