Complete recovery after early intraarterial recombinant tissue plasminogen activator thrombolysis of carotid T occlusion

Alejandro Rabinstein, E. F M Wijdicks, Douglas A. Nichols

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Carotid T occlusion (intracranial carotid bifurcation occlusion with involvement of A1 and M1 segments) is associated with poor outcome. In most cases, treatment with intraarterial thrombolysis within a 6-hour window has been unsuccessful. We describe the case of a 26-year-old woman who presented with severe neurologic deficits (National Institutes of Health Stroke Scale score of 23) secondary to angiographically proved right carotid T occlusion. She was treated with intraarterial infusion of recombinant tissue plasminogen activator that was started less than 3 hours after symptom onset (26 mg administered during 2 hours 15 minutes). Thrombolysis resulted in recanalization of all major intracranial vessels and complete neurologic recovery. Early intraarterial thrombolysis may be effective in the treatment of patients with carotid T occlusion and should be considered for appropriate candidates.

Original languageEnglish (US)
Pages (from-to)1596-1599
Number of pages4
JournalAmerican Journal of Neuroradiology
Volume23
Issue number9
StatePublished - Oct 1 2002

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Tissue Plasminogen Activator
Intra Arterial Infusions
National Institutes of Health (U.S.)
Neurologic Manifestations
Nervous System
Stroke
Therapeutics

ASJC Scopus subject areas

  • Clinical Neurology
  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology

Cite this

Complete recovery after early intraarterial recombinant tissue plasminogen activator thrombolysis of carotid T occlusion. / Rabinstein, Alejandro; Wijdicks, E. F M; Nichols, Douglas A.

In: American Journal of Neuroradiology, Vol. 23, No. 9, 01.10.2002, p. 1596-1599.

Research output: Contribution to journalArticle

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