Compelling evidence for a prostate cancer gene at 22q12.3 by the international consortium for prostate cancer genetics

Nicola J. Camp, Lisa A. Cannon-Albright, James M. Farnham, Agnes B. Baffoe-Bonnie, Asha George, Isaac Powell, Joan E. Bailey-Wilson, John D. Carpten, Graham G. Giles, John L. Hopper, Gianluca Severi, Dallas R. English, William D. Foulkes, Lovise Maehle, Pal Moller, Ros Eeles, Douglas Easton, Michael D. Badzioch, Alice S. Whittemore, Ingrid Oakley-GirvanChih Lin Hsieh, Latchezar Dimitrov, Jianfeng Xu, Janet L. Stanford, Bo Johanneson, Kerry Deutsch, Laura McIntosh, Elaine A. Ostrander, Kathleen E. Wiley, Sarah D. Isaacs, Patrick C. Walsh, Stephen N Thibodeau, Shannon K. McDonnell, Scott Hebbring, Daniel J Schaid, Ethan M. Lange, Kathleen A. Cooney, Teuvo L J Tammela, Johanna Schleutker, Thomas Paiss, Christiane Maier, Henrik Grönberg, Fredrik Wiklund, Monica Emanuelsson, William B. Isaacs

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

Previously, an analysis of 14 extended, high-risk Utah pedigrees localized in the chromosome 22q linkage region to 3.2 Mb at 22q12.3-13.1 (flanked on each side by three recombinants) contained 31 annotated genes. In this large, multi-centered, collaborative study, we performed statistical recombinant mapping in 54 pedigrees selected to be informative for recombinant mapping from nine member groups of the International Consortium for Prostate Cancer Genetics (ICPCG). These 54 pedigrees included the 14 extended pedigrees from Utah and 40 pedigrees from eight other ICPCG member groups. The additional 40 pedigrees were selected from a total pool of 1213 such that each pedigree was required to contain both at least four prostate cancer (PRCA) cases and exhibit evidence for linkage to the chromosome 22q region. The recombinant events in these 40 independent pedigrees confirmed the previously proposed region. Further, when all 54 pedigrees were considered, the three-recombinant consensus region was narrowed down by more than a megabase to 2.2 Mb at chromosome 22q12.3 flanked by D22S281 and D22S683. This narrower region eliminated 20 annotated genes from that previously proposed, leaving only 11 genes. This region at 22q12.3 is the most consistently identified and smallest linkage region for PRCA. This collaborative study by the ICPCG illustrates the value of consortium efforts and the continued utility of linkage analysis using informative pedigrees to localize genes for complex diseases.

Original languageEnglish (US)
Pages (from-to)1271-1278
Number of pages8
JournalHuman Molecular Genetics
Volume16
Issue number11
DOIs
StatePublished - Jun 2007

Fingerprint

Neoplasm Genes
Pedigree
Prostatic Neoplasms
Chromosomes
Genes

ASJC Scopus subject areas

  • Genetics

Cite this

Camp, N. J., Cannon-Albright, L. A., Farnham, J. M., Baffoe-Bonnie, A. B., George, A., Powell, I., ... Isaacs, W. B. (2007). Compelling evidence for a prostate cancer gene at 22q12.3 by the international consortium for prostate cancer genetics. Human Molecular Genetics, 16(11), 1271-1278. https://doi.org/10.1093/hmg/ddm075

Compelling evidence for a prostate cancer gene at 22q12.3 by the international consortium for prostate cancer genetics. / Camp, Nicola J.; Cannon-Albright, Lisa A.; Farnham, James M.; Baffoe-Bonnie, Agnes B.; George, Asha; Powell, Isaac; Bailey-Wilson, Joan E.; Carpten, John D.; Giles, Graham G.; Hopper, John L.; Severi, Gianluca; English, Dallas R.; Foulkes, William D.; Maehle, Lovise; Moller, Pal; Eeles, Ros; Easton, Douglas; Badzioch, Michael D.; Whittemore, Alice S.; Oakley-Girvan, Ingrid; Hsieh, Chih Lin; Dimitrov, Latchezar; Xu, Jianfeng; Stanford, Janet L.; Johanneson, Bo; Deutsch, Kerry; McIntosh, Laura; Ostrander, Elaine A.; Wiley, Kathleen E.; Isaacs, Sarah D.; Walsh, Patrick C.; Thibodeau, Stephen N; McDonnell, Shannon K.; Hebbring, Scott; Schaid, Daniel J; Lange, Ethan M.; Cooney, Kathleen A.; Tammela, Teuvo L J; Schleutker, Johanna; Paiss, Thomas; Maier, Christiane; Grönberg, Henrik; Wiklund, Fredrik; Emanuelsson, Monica; Isaacs, William B.

In: Human Molecular Genetics, Vol. 16, No. 11, 06.2007, p. 1271-1278.

Research output: Contribution to journalArticle

Camp, NJ, Cannon-Albright, LA, Farnham, JM, Baffoe-Bonnie, AB, George, A, Powell, I, Bailey-Wilson, JE, Carpten, JD, Giles, GG, Hopper, JL, Severi, G, English, DR, Foulkes, WD, Maehle, L, Moller, P, Eeles, R, Easton, D, Badzioch, MD, Whittemore, AS, Oakley-Girvan, I, Hsieh, CL, Dimitrov, L, Xu, J, Stanford, JL, Johanneson, B, Deutsch, K, McIntosh, L, Ostrander, EA, Wiley, KE, Isaacs, SD, Walsh, PC, Thibodeau, SN, McDonnell, SK, Hebbring, S, Schaid, DJ, Lange, EM, Cooney, KA, Tammela, TLJ, Schleutker, J, Paiss, T, Maier, C, Grönberg, H, Wiklund, F, Emanuelsson, M & Isaacs, WB 2007, 'Compelling evidence for a prostate cancer gene at 22q12.3 by the international consortium for prostate cancer genetics', Human Molecular Genetics, vol. 16, no. 11, pp. 1271-1278. https://doi.org/10.1093/hmg/ddm075
Camp, Nicola J. ; Cannon-Albright, Lisa A. ; Farnham, James M. ; Baffoe-Bonnie, Agnes B. ; George, Asha ; Powell, Isaac ; Bailey-Wilson, Joan E. ; Carpten, John D. ; Giles, Graham G. ; Hopper, John L. ; Severi, Gianluca ; English, Dallas R. ; Foulkes, William D. ; Maehle, Lovise ; Moller, Pal ; Eeles, Ros ; Easton, Douglas ; Badzioch, Michael D. ; Whittemore, Alice S. ; Oakley-Girvan, Ingrid ; Hsieh, Chih Lin ; Dimitrov, Latchezar ; Xu, Jianfeng ; Stanford, Janet L. ; Johanneson, Bo ; Deutsch, Kerry ; McIntosh, Laura ; Ostrander, Elaine A. ; Wiley, Kathleen E. ; Isaacs, Sarah D. ; Walsh, Patrick C. ; Thibodeau, Stephen N ; McDonnell, Shannon K. ; Hebbring, Scott ; Schaid, Daniel J ; Lange, Ethan M. ; Cooney, Kathleen A. ; Tammela, Teuvo L J ; Schleutker, Johanna ; Paiss, Thomas ; Maier, Christiane ; Grönberg, Henrik ; Wiklund, Fredrik ; Emanuelsson, Monica ; Isaacs, William B. / Compelling evidence for a prostate cancer gene at 22q12.3 by the international consortium for prostate cancer genetics. In: Human Molecular Genetics. 2007 ; Vol. 16, No. 11. pp. 1271-1278.
@article{3964f124eb354e84a15cc584780281d3,
title = "Compelling evidence for a prostate cancer gene at 22q12.3 by the international consortium for prostate cancer genetics",
abstract = "Previously, an analysis of 14 extended, high-risk Utah pedigrees localized in the chromosome 22q linkage region to 3.2 Mb at 22q12.3-13.1 (flanked on each side by three recombinants) contained 31 annotated genes. In this large, multi-centered, collaborative study, we performed statistical recombinant mapping in 54 pedigrees selected to be informative for recombinant mapping from nine member groups of the International Consortium for Prostate Cancer Genetics (ICPCG). These 54 pedigrees included the 14 extended pedigrees from Utah and 40 pedigrees from eight other ICPCG member groups. The additional 40 pedigrees were selected from a total pool of 1213 such that each pedigree was required to contain both at least four prostate cancer (PRCA) cases and exhibit evidence for linkage to the chromosome 22q region. The recombinant events in these 40 independent pedigrees confirmed the previously proposed region. Further, when all 54 pedigrees were considered, the three-recombinant consensus region was narrowed down by more than a megabase to 2.2 Mb at chromosome 22q12.3 flanked by D22S281 and D22S683. This narrower region eliminated 20 annotated genes from that previously proposed, leaving only 11 genes. This region at 22q12.3 is the most consistently identified and smallest linkage region for PRCA. This collaborative study by the ICPCG illustrates the value of consortium efforts and the continued utility of linkage analysis using informative pedigrees to localize genes for complex diseases.",
author = "Camp, {Nicola J.} and Cannon-Albright, {Lisa A.} and Farnham, {James M.} and Baffoe-Bonnie, {Agnes B.} and Asha George and Isaac Powell and Bailey-Wilson, {Joan E.} and Carpten, {John D.} and Giles, {Graham G.} and Hopper, {John L.} and Gianluca Severi and English, {Dallas R.} and Foulkes, {William D.} and Lovise Maehle and Pal Moller and Ros Eeles and Douglas Easton and Badzioch, {Michael D.} and Whittemore, {Alice S.} and Ingrid Oakley-Girvan and Hsieh, {Chih Lin} and Latchezar Dimitrov and Jianfeng Xu and Stanford, {Janet L.} and Bo Johanneson and Kerry Deutsch and Laura McIntosh and Ostrander, {Elaine A.} and Wiley, {Kathleen E.} and Isaacs, {Sarah D.} and Walsh, {Patrick C.} and Thibodeau, {Stephen N} and McDonnell, {Shannon K.} and Scott Hebbring and Schaid, {Daniel J} and Lange, {Ethan M.} and Cooney, {Kathleen A.} and Tammela, {Teuvo L J} and Johanna Schleutker and Thomas Paiss and Christiane Maier and Henrik Gr{\"o}nberg and Fredrik Wiklund and Monica Emanuelsson and Isaacs, {William B.}",
year = "2007",
month = "6",
doi = "10.1093/hmg/ddm075",
language = "English (US)",
volume = "16",
pages = "1271--1278",
journal = "Human Molecular Genetics",
issn = "0964-6906",
publisher = "Oxford University Press",
number = "11",

}

TY - JOUR

T1 - Compelling evidence for a prostate cancer gene at 22q12.3 by the international consortium for prostate cancer genetics

AU - Camp, Nicola J.

AU - Cannon-Albright, Lisa A.

AU - Farnham, James M.

AU - Baffoe-Bonnie, Agnes B.

AU - George, Asha

AU - Powell, Isaac

AU - Bailey-Wilson, Joan E.

AU - Carpten, John D.

AU - Giles, Graham G.

AU - Hopper, John L.

AU - Severi, Gianluca

AU - English, Dallas R.

AU - Foulkes, William D.

AU - Maehle, Lovise

AU - Moller, Pal

AU - Eeles, Ros

AU - Easton, Douglas

AU - Badzioch, Michael D.

AU - Whittemore, Alice S.

AU - Oakley-Girvan, Ingrid

AU - Hsieh, Chih Lin

AU - Dimitrov, Latchezar

AU - Xu, Jianfeng

AU - Stanford, Janet L.

AU - Johanneson, Bo

AU - Deutsch, Kerry

AU - McIntosh, Laura

AU - Ostrander, Elaine A.

AU - Wiley, Kathleen E.

AU - Isaacs, Sarah D.

AU - Walsh, Patrick C.

AU - Thibodeau, Stephen N

AU - McDonnell, Shannon K.

AU - Hebbring, Scott

AU - Schaid, Daniel J

AU - Lange, Ethan M.

AU - Cooney, Kathleen A.

AU - Tammela, Teuvo L J

AU - Schleutker, Johanna

AU - Paiss, Thomas

AU - Maier, Christiane

AU - Grönberg, Henrik

AU - Wiklund, Fredrik

AU - Emanuelsson, Monica

AU - Isaacs, William B.

PY - 2007/6

Y1 - 2007/6

N2 - Previously, an analysis of 14 extended, high-risk Utah pedigrees localized in the chromosome 22q linkage region to 3.2 Mb at 22q12.3-13.1 (flanked on each side by three recombinants) contained 31 annotated genes. In this large, multi-centered, collaborative study, we performed statistical recombinant mapping in 54 pedigrees selected to be informative for recombinant mapping from nine member groups of the International Consortium for Prostate Cancer Genetics (ICPCG). These 54 pedigrees included the 14 extended pedigrees from Utah and 40 pedigrees from eight other ICPCG member groups. The additional 40 pedigrees were selected from a total pool of 1213 such that each pedigree was required to contain both at least four prostate cancer (PRCA) cases and exhibit evidence for linkage to the chromosome 22q region. The recombinant events in these 40 independent pedigrees confirmed the previously proposed region. Further, when all 54 pedigrees were considered, the three-recombinant consensus region was narrowed down by more than a megabase to 2.2 Mb at chromosome 22q12.3 flanked by D22S281 and D22S683. This narrower region eliminated 20 annotated genes from that previously proposed, leaving only 11 genes. This region at 22q12.3 is the most consistently identified and smallest linkage region for PRCA. This collaborative study by the ICPCG illustrates the value of consortium efforts and the continued utility of linkage analysis using informative pedigrees to localize genes for complex diseases.

AB - Previously, an analysis of 14 extended, high-risk Utah pedigrees localized in the chromosome 22q linkage region to 3.2 Mb at 22q12.3-13.1 (flanked on each side by three recombinants) contained 31 annotated genes. In this large, multi-centered, collaborative study, we performed statistical recombinant mapping in 54 pedigrees selected to be informative for recombinant mapping from nine member groups of the International Consortium for Prostate Cancer Genetics (ICPCG). These 54 pedigrees included the 14 extended pedigrees from Utah and 40 pedigrees from eight other ICPCG member groups. The additional 40 pedigrees were selected from a total pool of 1213 such that each pedigree was required to contain both at least four prostate cancer (PRCA) cases and exhibit evidence for linkage to the chromosome 22q region. The recombinant events in these 40 independent pedigrees confirmed the previously proposed region. Further, when all 54 pedigrees were considered, the three-recombinant consensus region was narrowed down by more than a megabase to 2.2 Mb at chromosome 22q12.3 flanked by D22S281 and D22S683. This narrower region eliminated 20 annotated genes from that previously proposed, leaving only 11 genes. This region at 22q12.3 is the most consistently identified and smallest linkage region for PRCA. This collaborative study by the ICPCG illustrates the value of consortium efforts and the continued utility of linkage analysis using informative pedigrees to localize genes for complex diseases.

UR - http://www.scopus.com/inward/record.url?scp=34447299666&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=34447299666&partnerID=8YFLogxK

U2 - 10.1093/hmg/ddm075

DO - 10.1093/hmg/ddm075

M3 - Article

C2 - 17478474

AN - SCOPUS:34447299666

VL - 16

SP - 1271

EP - 1278

JO - Human Molecular Genetics

JF - Human Molecular Genetics

SN - 0964-6906

IS - 11

ER -