Comparison of two free light chain assays: performance of the involved free light chain ratio and implications for diagnosis of multiple myeloma

Maria Alice V. Willrich; David L. Murray; S. Vincent Rajkumar; Sandra C. Bryant; Dirk Larson; Vanessa Pazdernik; Melissa R. Snyder; Robert A. Kyle; Angela Dispenzieri

doi:10.1038/s41408-022-00722-5

Comparison of two free light chain assays: performance of the involved free light chain ratio and implications for diagnosis of multiple myeloma

Maria Alice V. Willrich, David L. Murray, S. Vincent Rajkumar, Sandra C. Bryant, Dirk Larson, Vanessa Pazdernik, Melissa R. Snyder, Robert A. Kyle, Angela Dispenzieri

Hematology

Research output: Contribution to journal › Letter › peer-review

Original language	English (US)
Article number	127
Journal	Blood cancer journal
Volume	12
Issue number	9
DOIs	https://doi.org/10.1038/s41408-022-00722-5
State	Published - Sep 2022

ASJC Scopus subject areas

Hematology
Oncology

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10.1038/s41408-022-00722-5

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Willrich, M. A. V., Murray, D. L., Rajkumar, S. V., Bryant, S. C., Larson, D., Pazdernik, V., Snyder, M. R., Kyle, R. A., & Dispenzieri, A. (2022). Comparison of two free light chain assays: performance of the involved free light chain ratio and implications for diagnosis of multiple myeloma. Blood cancer journal, 12(9), Article 127. https://doi.org/10.1038/s41408-022-00722-5

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title = "Comparison of two free light chain assays: performance of the involved free light chain ratio and implications for diagnosis of multiple myeloma",

author = "Willrich, {Maria Alice V.} and Murray, {David L.} and Rajkumar, {S. Vincent} and Bryant, {Sandra C.} and Dirk Larson and Vanessa Pazdernik and Snyder, {Melissa R.} and Kyle, {Robert A.} and Angela Dispenzieri",

note = "Funding Information: The authors would like to thank the clinical laboratory staff in the Department of Laboratory Medicine and Pathology at Mayo Clinic Rochester, MN, for testing samples and managing sample sets: Brandon T. Copet, Mary Therese J. Pido, James M. Larkin, Tewodrose K. Tamire, Zachary V. Som, Kyle T. Herbstritt, Brett M. Hirner, Daniel M. Kuol, Stephanie J. Kalass, Mark A. Martinez, Michael W. Nelson, Matthew J. Kurke, Cassandra R. Poterucha, Rose J. Bengal, Cory S. Blixt, Justin A. Dunker, Jennifer B. Quam, and Page E. McCarthy. This study was supported by BioPharma Diagnostics, a business support unit within the Mayo Clinic Department of Laboratory Medicine and Pathology and Sebia Inc. (Lisses, France). Funding Information: This study was sponsored by Sebia Inc. (Lisses, France). The sponsor had no role in the data analysis. Additional funding to the Mayo Clinic includes grants numbers: P01 CA062242/CA/NCI NIH HHS, P50 CA100707/CA/NCI NIH HHS, R01 CA083724/CA/NCI NIH HHS, R01 CA107476/CA/NCI NIH HHS, R01 CA168762/CA/NCI NIH HHS, P50 CA186781//CA/NCI NIH HHS, JABBS foundation and Predolin foundation. AD and MAVW participated in an advisory board for Myeloma360 in 2021. The authors declare no other conflict of interest pertaining to this work. ",

year = "2022",

month = sep,

doi = "10.1038/s41408-022-00722-5",

language = "English (US)",

volume = "12",

journal = "Blood cancer journal",

issn = "2044-5385",

publisher = "Nature Publishing Group",

number = "9",

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T2 - performance of the involved free light chain ratio and implications for diagnosis of multiple myeloma

AU - Willrich, Maria Alice V.

AU - Murray, David L.

AU - Rajkumar, S. Vincent

AU - Bryant, Sandra C.

AU - Larson, Dirk

AU - Pazdernik, Vanessa

AU - Snyder, Melissa R.

AU - Kyle, Robert A.

AU - Dispenzieri, Angela

N1 - Funding Information: The authors would like to thank the clinical laboratory staff in the Department of Laboratory Medicine and Pathology at Mayo Clinic Rochester, MN, for testing samples and managing sample sets: Brandon T. Copet, Mary Therese J. Pido, James M. Larkin, Tewodrose K. Tamire, Zachary V. Som, Kyle T. Herbstritt, Brett M. Hirner, Daniel M. Kuol, Stephanie J. Kalass, Mark A. Martinez, Michael W. Nelson, Matthew J. Kurke, Cassandra R. Poterucha, Rose J. Bengal, Cory S. Blixt, Justin A. Dunker, Jennifer B. Quam, and Page E. McCarthy. This study was supported by BioPharma Diagnostics, a business support unit within the Mayo Clinic Department of Laboratory Medicine and Pathology and Sebia Inc. (Lisses, France). Funding Information: This study was sponsored by Sebia Inc. (Lisses, France). The sponsor had no role in the data analysis. Additional funding to the Mayo Clinic includes grants numbers: P01 CA062242/CA/NCI NIH HHS, P50 CA100707/CA/NCI NIH HHS, R01 CA083724/CA/NCI NIH HHS, R01 CA107476/CA/NCI NIH HHS, R01 CA168762/CA/NCI NIH HHS, P50 CA186781//CA/NCI NIH HHS, JABBS foundation and Predolin foundation. AD and MAVW participated in an advisory board for Myeloma360 in 2021. The authors declare no other conflict of interest pertaining to this work.

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Comparison of two free light chain assays: performance of the involved free light chain ratio and implications for diagnosis of multiple myeloma

ASJC Scopus subject areas

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