Comparison of transarterial liver-directed therapies for low-grade metastatic neuroendocrine tumors in a single institution

Eric S. Engelman, Roberto Leon-Ferre, Boris G. Naraev, Nancy Sharma, Shiliang Sun, Thomas M. O'Dorisio, James Howe, Anna Button, Gideon Zamba, Thorvardur R. Halfdanarson

Research output: Contribution to journalArticlepeer-review

21 Scopus citations

Abstract

OBJECTIVE: We compared the clinical outcomes of patients with metastatic neuroendocrine tumors treated with hepatic artery embolization (HAE), chemoembolization (HACE), and selective internal radiation therapy (SIRT) at our institution over the last 10 years. METHODS: The medical records of 42 patients with metastatic neuroendocrine tumors with hepatic metastases treated with HAE, HACE, or SIRT at the University of Iowa from 2001 to 2011 were analyzed. RESULTS: A total of 13 patients had HAE, 17 patients had HACE, and 12 patients had SIRT as their initial procedure. Time to progression (TTP) was similar between SIRT (15.1 months) and HACE/HAE groups (19.6 months; P = 0.968). There was a trend toward increased TTP in patients receiving HACE (33.4 months) compared with HAE (12.1 months) or SIRT (15.1 months), although not statistically significant (P = 0.512). The overall survival for all patients from the first intervention was 41.9 months. There was no difference between HACE/HAE and SIRT in posttherapy change of chromogranin A (P = 0.233) and pancreastatin (P = 0.158) levels. Time to progression did not correlate with the change in the posttherapy chromogranin A (P = 0.299) or pancreastatin (P = 0.208) levels. CONCLUSIONS: There was no significant difference in TTP in patients treated with SIRT compared with patients treated with HAE or HACE. Baseline and posttherapy marker changes were not predictive of TTP.

Original languageEnglish (US)
Pages (from-to)219-225
Number of pages7
JournalPancreas
Volume43
Issue number2
DOIs
StatePublished - Mar 2014

Keywords

  • chemoembolization
  • chromogranin A
  • hepatic artery embolization
  • neuroendocrine tumors
  • pancreastatin
  • transarterial liver-directed therapies

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Hepatology
  • Endocrinology

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