TY - JOUR
T1 - Comparison of transarterial liver-directed therapies for low-grade metastatic neuroendocrine tumors in a single institution
AU - Engelman, Eric S.
AU - Leon-Ferre, Roberto
AU - Naraev, Boris G.
AU - Sharma, Nancy
AU - Sun, Shiliang
AU - O'Dorisio, Thomas M.
AU - Howe, James
AU - Button, Anna
AU - Zamba, Gideon
AU - Halfdanarson, Thorvardur R.
PY - 2014/3
Y1 - 2014/3
N2 - OBJECTIVE: We compared the clinical outcomes of patients with metastatic neuroendocrine tumors treated with hepatic artery embolization (HAE), chemoembolization (HACE), and selective internal radiation therapy (SIRT) at our institution over the last 10 years. METHODS: The medical records of 42 patients with metastatic neuroendocrine tumors with hepatic metastases treated with HAE, HACE, or SIRT at the University of Iowa from 2001 to 2011 were analyzed. RESULTS: A total of 13 patients had HAE, 17 patients had HACE, and 12 patients had SIRT as their initial procedure. Time to progression (TTP) was similar between SIRT (15.1 months) and HACE/HAE groups (19.6 months; P = 0.968). There was a trend toward increased TTP in patients receiving HACE (33.4 months) compared with HAE (12.1 months) or SIRT (15.1 months), although not statistically significant (P = 0.512). The overall survival for all patients from the first intervention was 41.9 months. There was no difference between HACE/HAE and SIRT in posttherapy change of chromogranin A (P = 0.233) and pancreastatin (P = 0.158) levels. Time to progression did not correlate with the change in the posttherapy chromogranin A (P = 0.299) or pancreastatin (P = 0.208) levels. CONCLUSIONS: There was no significant difference in TTP in patients treated with SIRT compared with patients treated with HAE or HACE. Baseline and posttherapy marker changes were not predictive of TTP.
AB - OBJECTIVE: We compared the clinical outcomes of patients with metastatic neuroendocrine tumors treated with hepatic artery embolization (HAE), chemoembolization (HACE), and selective internal radiation therapy (SIRT) at our institution over the last 10 years. METHODS: The medical records of 42 patients with metastatic neuroendocrine tumors with hepatic metastases treated with HAE, HACE, or SIRT at the University of Iowa from 2001 to 2011 were analyzed. RESULTS: A total of 13 patients had HAE, 17 patients had HACE, and 12 patients had SIRT as their initial procedure. Time to progression (TTP) was similar between SIRT (15.1 months) and HACE/HAE groups (19.6 months; P = 0.968). There was a trend toward increased TTP in patients receiving HACE (33.4 months) compared with HAE (12.1 months) or SIRT (15.1 months), although not statistically significant (P = 0.512). The overall survival for all patients from the first intervention was 41.9 months. There was no difference between HACE/HAE and SIRT in posttherapy change of chromogranin A (P = 0.233) and pancreastatin (P = 0.158) levels. Time to progression did not correlate with the change in the posttherapy chromogranin A (P = 0.299) or pancreastatin (P = 0.208) levels. CONCLUSIONS: There was no significant difference in TTP in patients treated with SIRT compared with patients treated with HAE or HACE. Baseline and posttherapy marker changes were not predictive of TTP.
KW - chemoembolization
KW - chromogranin A
KW - hepatic artery embolization
KW - neuroendocrine tumors
KW - pancreastatin
KW - transarterial liver-directed therapies
UR - http://www.scopus.com/inward/record.url?scp=84894420642&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84894420642&partnerID=8YFLogxK
U2 - 10.1097/MPA.0000000000000030
DO - 10.1097/MPA.0000000000000030
M3 - Article
C2 - 24518499
AN - SCOPUS:84894420642
SN - 0885-3177
VL - 43
SP - 219
EP - 225
JO - Pancreas
JF - Pancreas
IS - 2
ER -