Comparison of the efficacy of betaxolol-brinzolamide and timolol- dorzolamide as suppressors of aqueous humor flow in human subjects

Richard F. Brubaker; Cory J. Ingram; Erik O. Schoff; Cherie B. Nau

doi:10.1016/S0161-6420(99)00044-5

Comparison of the efficacy of betaxolol-brinzolamide and timolol- dorzolamide as suppressors of aqueous humor flow in human subjects

Richard F. Brubaker, Cory J. Ingram, Erik O. Schoff, Cherie B. Nau

Family Medicine

Research output: Contribution to journal › Article › peer-review

21 Scopus citations

Abstract

Objective: To compare the efficacy of combinations of betaxolol- brinzolamide and timolol-dorzolamide as suppressors of aqueous humor flow and ocular hypotensive agents. Design: Placebo-controlled, masked comparison of the two drug combinations. Participants: Twenty-five normal human volunteers with the fellow eye serving as control. Methods or Testing: Fluorophotometric measurement of aqueous humor flow and pneumatonometric measurement of intraocular pressure. Main Outcome Measures: Aqueous humor flow and intraocular pressure. Results: The betaxolol-brinzolamide combination lowered aqueous flow 39% to 44%, and the timolol-dorzolamide combination lowered aqueous flow 51%. The betaxolol-brinzolamide combination lowered intraocular pressure 14% to 19%, and the timolol-dorzolamide combination lowered it 18% to 24%. Conclusions: Both drug combinations were effective; the timolol- dorzolamide combination appeared to be the more effective of the two after short-term exposure (24 hours). (C) 2000 by the Mayo Foundation.

Original language	English (US)
Pages (from-to)	283-287
Number of pages	5
Journal	Ophthalmology
Volume	107
Issue number	2
DOIs	https://doi.org/10.1016/S0161-6420(99)00044-5
State	Published - Feb 2000

ASJC Scopus subject areas

Ophthalmology

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10.1016/S0161-6420(99)00044-5

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title = "Comparison of the efficacy of betaxolol-brinzolamide and timolol- dorzolamide as suppressors of aqueous humor flow in human subjects",

abstract = "Objective: To compare the efficacy of combinations of betaxolol- brinzolamide and timolol-dorzolamide as suppressors of aqueous humor flow and ocular hypotensive agents. Design: Placebo-controlled, masked comparison of the two drug combinations. Participants: Twenty-five normal human volunteers with the fellow eye serving as control. Methods or Testing: Fluorophotometric measurement of aqueous humor flow and pneumatonometric measurement of intraocular pressure. Main Outcome Measures: Aqueous humor flow and intraocular pressure. Results: The betaxolol-brinzolamide combination lowered aqueous flow 39% to 44%, and the timolol-dorzolamide combination lowered aqueous flow 51%. The betaxolol-brinzolamide combination lowered intraocular pressure 14% to 19%, and the timolol-dorzolamide combination lowered it 18% to 24%. Conclusions: Both drug combinations were effective; the timolol- dorzolamide combination appeared to be the more effective of the two after short-term exposure (24 hours). (C) 2000 by the Mayo Foundation.",

author = "Brubaker, {Richard F.} and Ingram, {Cory J.} and Schoff, {Erik O.} and Nau, {Cherie B.}",

note = "Funding Information: Supported in part by NIH grant EY 00634 from the National Institutes of Health, Bethesda, MD; an unrestricted grant from Research to Prevent Blindness, Inc., New York, NY; the Bonner Foundation, Princeton, NJ; and the Mayo Foundation, Rochester, MN. ",

year = "2000",

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doi = "10.1016/S0161-6420(99)00044-5",

language = "English (US)",

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AU - Brubaker, Richard F.

AU - Ingram, Cory J.

AU - Schoff, Erik O.

AU - Nau, Cherie B.

N1 - Funding Information: Supported in part by NIH grant EY 00634 from the National Institutes of Health, Bethesda, MD; an unrestricted grant from Research to Prevent Blindness, Inc., New York, NY; the Bonner Foundation, Princeton, NJ; and the Mayo Foundation, Rochester, MN.

PY - 2000/2

Y1 - 2000/2

N2 - Objective: To compare the efficacy of combinations of betaxolol- brinzolamide and timolol-dorzolamide as suppressors of aqueous humor flow and ocular hypotensive agents. Design: Placebo-controlled, masked comparison of the two drug combinations. Participants: Twenty-five normal human volunteers with the fellow eye serving as control. Methods or Testing: Fluorophotometric measurement of aqueous humor flow and pneumatonometric measurement of intraocular pressure. Main Outcome Measures: Aqueous humor flow and intraocular pressure. Results: The betaxolol-brinzolamide combination lowered aqueous flow 39% to 44%, and the timolol-dorzolamide combination lowered aqueous flow 51%. The betaxolol-brinzolamide combination lowered intraocular pressure 14% to 19%, and the timolol-dorzolamide combination lowered it 18% to 24%. Conclusions: Both drug combinations were effective; the timolol- dorzolamide combination appeared to be the more effective of the two after short-term exposure (24 hours). (C) 2000 by the Mayo Foundation.

AB - Objective: To compare the efficacy of combinations of betaxolol- brinzolamide and timolol-dorzolamide as suppressors of aqueous humor flow and ocular hypotensive agents. Design: Placebo-controlled, masked comparison of the two drug combinations. Participants: Twenty-five normal human volunteers with the fellow eye serving as control. Methods or Testing: Fluorophotometric measurement of aqueous humor flow and pneumatonometric measurement of intraocular pressure. Main Outcome Measures: Aqueous humor flow and intraocular pressure. Results: The betaxolol-brinzolamide combination lowered aqueous flow 39% to 44%, and the timolol-dorzolamide combination lowered aqueous flow 51%. The betaxolol-brinzolamide combination lowered intraocular pressure 14% to 19%, and the timolol-dorzolamide combination lowered it 18% to 24%. Conclusions: Both drug combinations were effective; the timolol- dorzolamide combination appeared to be the more effective of the two after short-term exposure (24 hours). (C) 2000 by the Mayo Foundation.

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Comparison of the efficacy of betaxolol-brinzolamide and timolol- dorzolamide as suppressors of aqueous humor flow in human subjects

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