Comparison of symptoms, chemistry, and nerve function to assess adequacy of hemodialysis

Peter J Dyck, W. J. Johnson, E. H. Lambert, P. C. O'Brien, J. R. Daube, K. F. Oviatt

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

To determine whether symptoms of uremia, serum urea, serum creatine, or nerve function tests provided the most sensitive and reliable index on which to judge the need for hemodialysis, we entered 22 patients in a controlled trial of short or long hemodialysis thrice weekly. Short hemodialysis consisted of 1 1/2 hours for women and 2 hours for men, whereas long dialysis consisted of 3 hours for women and 4 hours for men. Nerve function tests included scored neurologic disability, muscle strength, computerized tests of cutaneous sensation, and nerve conduction studies. Of nine patients in the short hemodialysis group, three remained free of symptoms of uremia, pericarditis developed in two, and pleurisy and ascites developed in one each. Only three could be maintained on the schedule for the full 12 months of the study. In contrast, all 13 patients in the long hemodialysis group remained free of such symptoms and signs, and could be maintained on the schedule for the full study. Despite the difference in duration of dialysis and the clinical response, predialysis urea and creatinine values and tests of nerve function did not provide a clear index of need for dialysis. Even in the three patients with unequivocal symptoms of uremia, serial tests failed to show worsening of nerve function. Therefore, predialysis urea and creatinine values and tests of peripheral nerve function do not appear to be sensitive or reliable indices by the practicing nephrologist can adjust the amount of hemodialysis from day to day. Although tests of nerve function might indicate a need for more hemodialysis when inadequate hemodialysis has been extended for long periods, we do not detect significant differences in scored neurologic findings between the two hemodialysis treatment schedules when our results were projected to the end of a year.

Original languageEnglish (US)
Pages (from-to)1361-1368
Number of pages8
JournalNeurology
Volume29
Issue number10
StatePublished - 1979

Fingerprint

Renal Dialysis
Uremia
Urea
Dialysis
Appointments and Schedules
Creatinine
Pleurisy
Pericarditis
Creatine
Neural Conduction
Muscle Strength
Neurologic Manifestations
Serum
Peripheral Nerves
Ascites
Nervous System
Signs and Symptoms
Skin

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Dyck, P. J., Johnson, W. J., Lambert, E. H., O'Brien, P. C., Daube, J. R., & Oviatt, K. F. (1979). Comparison of symptoms, chemistry, and nerve function to assess adequacy of hemodialysis. Neurology, 29(10), 1361-1368.

Comparison of symptoms, chemistry, and nerve function to assess adequacy of hemodialysis. / Dyck, Peter J; Johnson, W. J.; Lambert, E. H.; O'Brien, P. C.; Daube, J. R.; Oviatt, K. F.

In: Neurology, Vol. 29, No. 10, 1979, p. 1361-1368.

Research output: Contribution to journalArticle

Dyck, PJ, Johnson, WJ, Lambert, EH, O'Brien, PC, Daube, JR & Oviatt, KF 1979, 'Comparison of symptoms, chemistry, and nerve function to assess adequacy of hemodialysis', Neurology, vol. 29, no. 10, pp. 1361-1368.
Dyck PJ, Johnson WJ, Lambert EH, O'Brien PC, Daube JR, Oviatt KF. Comparison of symptoms, chemistry, and nerve function to assess adequacy of hemodialysis. Neurology. 1979;29(10):1361-1368.
Dyck, Peter J ; Johnson, W. J. ; Lambert, E. H. ; O'Brien, P. C. ; Daube, J. R. ; Oviatt, K. F. / Comparison of symptoms, chemistry, and nerve function to assess adequacy of hemodialysis. In: Neurology. 1979 ; Vol. 29, No. 10. pp. 1361-1368.
@article{7a9b05064ba9419ebebbe733887e7403,
title = "Comparison of symptoms, chemistry, and nerve function to assess adequacy of hemodialysis",
abstract = "To determine whether symptoms of uremia, serum urea, serum creatine, or nerve function tests provided the most sensitive and reliable index on which to judge the need for hemodialysis, we entered 22 patients in a controlled trial of short or long hemodialysis thrice weekly. Short hemodialysis consisted of 1 1/2 hours for women and 2 hours for men, whereas long dialysis consisted of 3 hours for women and 4 hours for men. Nerve function tests included scored neurologic disability, muscle strength, computerized tests of cutaneous sensation, and nerve conduction studies. Of nine patients in the short hemodialysis group, three remained free of symptoms of uremia, pericarditis developed in two, and pleurisy and ascites developed in one each. Only three could be maintained on the schedule for the full 12 months of the study. In contrast, all 13 patients in the long hemodialysis group remained free of such symptoms and signs, and could be maintained on the schedule for the full study. Despite the difference in duration of dialysis and the clinical response, predialysis urea and creatinine values and tests of nerve function did not provide a clear index of need for dialysis. Even in the three patients with unequivocal symptoms of uremia, serial tests failed to show worsening of nerve function. Therefore, predialysis urea and creatinine values and tests of peripheral nerve function do not appear to be sensitive or reliable indices by the practicing nephrologist can adjust the amount of hemodialysis from day to day. Although tests of nerve function might indicate a need for more hemodialysis when inadequate hemodialysis has been extended for long periods, we do not detect significant differences in scored neurologic findings between the two hemodialysis treatment schedules when our results were projected to the end of a year.",
author = "Dyck, {Peter J} and Johnson, {W. J.} and Lambert, {E. H.} and O'Brien, {P. C.} and Daube, {J. R.} and Oviatt, {K. F.}",
year = "1979",
language = "English (US)",
volume = "29",
pages = "1361--1368",
journal = "Neurology",
issn = "0028-3878",
publisher = "Lippincott Williams and Wilkins",
number = "10",

}

TY - JOUR

T1 - Comparison of symptoms, chemistry, and nerve function to assess adequacy of hemodialysis

AU - Dyck, Peter J

AU - Johnson, W. J.

AU - Lambert, E. H.

AU - O'Brien, P. C.

AU - Daube, J. R.

AU - Oviatt, K. F.

PY - 1979

Y1 - 1979

N2 - To determine whether symptoms of uremia, serum urea, serum creatine, or nerve function tests provided the most sensitive and reliable index on which to judge the need for hemodialysis, we entered 22 patients in a controlled trial of short or long hemodialysis thrice weekly. Short hemodialysis consisted of 1 1/2 hours for women and 2 hours for men, whereas long dialysis consisted of 3 hours for women and 4 hours for men. Nerve function tests included scored neurologic disability, muscle strength, computerized tests of cutaneous sensation, and nerve conduction studies. Of nine patients in the short hemodialysis group, three remained free of symptoms of uremia, pericarditis developed in two, and pleurisy and ascites developed in one each. Only three could be maintained on the schedule for the full 12 months of the study. In contrast, all 13 patients in the long hemodialysis group remained free of such symptoms and signs, and could be maintained on the schedule for the full study. Despite the difference in duration of dialysis and the clinical response, predialysis urea and creatinine values and tests of nerve function did not provide a clear index of need for dialysis. Even in the three patients with unequivocal symptoms of uremia, serial tests failed to show worsening of nerve function. Therefore, predialysis urea and creatinine values and tests of peripheral nerve function do not appear to be sensitive or reliable indices by the practicing nephrologist can adjust the amount of hemodialysis from day to day. Although tests of nerve function might indicate a need for more hemodialysis when inadequate hemodialysis has been extended for long periods, we do not detect significant differences in scored neurologic findings between the two hemodialysis treatment schedules when our results were projected to the end of a year.

AB - To determine whether symptoms of uremia, serum urea, serum creatine, or nerve function tests provided the most sensitive and reliable index on which to judge the need for hemodialysis, we entered 22 patients in a controlled trial of short or long hemodialysis thrice weekly. Short hemodialysis consisted of 1 1/2 hours for women and 2 hours for men, whereas long dialysis consisted of 3 hours for women and 4 hours for men. Nerve function tests included scored neurologic disability, muscle strength, computerized tests of cutaneous sensation, and nerve conduction studies. Of nine patients in the short hemodialysis group, three remained free of symptoms of uremia, pericarditis developed in two, and pleurisy and ascites developed in one each. Only three could be maintained on the schedule for the full 12 months of the study. In contrast, all 13 patients in the long hemodialysis group remained free of such symptoms and signs, and could be maintained on the schedule for the full study. Despite the difference in duration of dialysis and the clinical response, predialysis urea and creatinine values and tests of nerve function did not provide a clear index of need for dialysis. Even in the three patients with unequivocal symptoms of uremia, serial tests failed to show worsening of nerve function. Therefore, predialysis urea and creatinine values and tests of peripheral nerve function do not appear to be sensitive or reliable indices by the practicing nephrologist can adjust the amount of hemodialysis from day to day. Although tests of nerve function might indicate a need for more hemodialysis when inadequate hemodialysis has been extended for long periods, we do not detect significant differences in scored neurologic findings between the two hemodialysis treatment schedules when our results were projected to the end of a year.

UR - http://www.scopus.com/inward/record.url?scp=0018293816&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0018293816&partnerID=8YFLogxK

M3 - Article

C2 - 573380

AN - SCOPUS:0018293816

VL - 29

SP - 1361

EP - 1368

JO - Neurology

JF - Neurology

SN - 0028-3878

IS - 10

ER -