Comparison of six pharmacologic regimens for hypercholesterolemia

Jeffrey M. Hoeg, Martha B. Maher, Kent R Bailey, H. Bryan Brewer

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Six sequential clinical trials were conducted over 5 years to evaluate the safety and efficacy of different treatment regimens for hypercholesterolemia. Of all the study participants, 11 patients were evaluated in all 6 clinical trials using the following regimens: neomycin, neomycin/niacin, cholestyramine, cholestyramine/neomycin, lovastatin and lovastatin/neomycin. All 6 regimens significantly (p <0.05) reduced both total and low-density lipoprotein cholesterol concentrations by 25 to 42 % from baseline levels. Only neomycin/niacin, cholestyramine and lovastatin significantly increased the high-density lipoprotein (HDL) cholesterol concentration, reducing the total cholesterol/high-density lipoprotein cholesterol ratio to less than 4.7. Thus, all 6 tested regimens were effective in modifying the plasma lipoprotein concentrations in type 11 hyperlipoproteinemia, but neomydn/niacin, cholestyramine and lovastatin had the most favorable Impact. Only lovastatin treatment was free of adverse effects.

Original languageEnglish (US)
JournalThe American Journal of Cardiology
Volume59
Issue number8
DOIs
StatePublished - Apr 1 1987
Externally publishedYes

Fingerprint

Lovastatin
Neomycin
Cholestyramine Resin
Hypercholesterolemia
Niacin
HDL Cholesterol
Clinical Trials
Hyperlipoproteinemias
LDL Cholesterol
Lipoproteins
Cholesterol
Safety

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Comparison of six pharmacologic regimens for hypercholesterolemia. / Hoeg, Jeffrey M.; Maher, Martha B.; Bailey, Kent R; Brewer, H. Bryan.

In: The American Journal of Cardiology, Vol. 59, No. 8, 01.04.1987.

Research output: Contribution to journalArticle

Hoeg, Jeffrey M. ; Maher, Martha B. ; Bailey, Kent R ; Brewer, H. Bryan. / Comparison of six pharmacologic regimens for hypercholesterolemia. In: The American Journal of Cardiology. 1987 ; Vol. 59, No. 8.
@article{6d0a1514712d43c29890ab64579b10f7,
title = "Comparison of six pharmacologic regimens for hypercholesterolemia",
abstract = "Six sequential clinical trials were conducted over 5 years to evaluate the safety and efficacy of different treatment regimens for hypercholesterolemia. Of all the study participants, 11 patients were evaluated in all 6 clinical trials using the following regimens: neomycin, neomycin/niacin, cholestyramine, cholestyramine/neomycin, lovastatin and lovastatin/neomycin. All 6 regimens significantly (p <0.05) reduced both total and low-density lipoprotein cholesterol concentrations by 25 to 42 {\%} from baseline levels. Only neomycin/niacin, cholestyramine and lovastatin significantly increased the high-density lipoprotein (HDL) cholesterol concentration, reducing the total cholesterol/high-density lipoprotein cholesterol ratio to less than 4.7. Thus, all 6 tested regimens were effective in modifying the plasma lipoprotein concentrations in type 11 hyperlipoproteinemia, but neomydn/niacin, cholestyramine and lovastatin had the most favorable Impact. Only lovastatin treatment was free of adverse effects.",
author = "Hoeg, {Jeffrey M.} and Maher, {Martha B.} and Bailey, {Kent R} and Brewer, {H. Bryan}",
year = "1987",
month = "4",
day = "1",
doi = "10.1016/0002-9149(87)91097-6",
language = "English (US)",
volume = "59",
journal = "American Journal of Cardiology",
issn = "0002-9149",
publisher = "Elsevier Inc.",
number = "8",

}

TY - JOUR

T1 - Comparison of six pharmacologic regimens for hypercholesterolemia

AU - Hoeg, Jeffrey M.

AU - Maher, Martha B.

AU - Bailey, Kent R

AU - Brewer, H. Bryan

PY - 1987/4/1

Y1 - 1987/4/1

N2 - Six sequential clinical trials were conducted over 5 years to evaluate the safety and efficacy of different treatment regimens for hypercholesterolemia. Of all the study participants, 11 patients were evaluated in all 6 clinical trials using the following regimens: neomycin, neomycin/niacin, cholestyramine, cholestyramine/neomycin, lovastatin and lovastatin/neomycin. All 6 regimens significantly (p <0.05) reduced both total and low-density lipoprotein cholesterol concentrations by 25 to 42 % from baseline levels. Only neomycin/niacin, cholestyramine and lovastatin significantly increased the high-density lipoprotein (HDL) cholesterol concentration, reducing the total cholesterol/high-density lipoprotein cholesterol ratio to less than 4.7. Thus, all 6 tested regimens were effective in modifying the plasma lipoprotein concentrations in type 11 hyperlipoproteinemia, but neomydn/niacin, cholestyramine and lovastatin had the most favorable Impact. Only lovastatin treatment was free of adverse effects.

AB - Six sequential clinical trials were conducted over 5 years to evaluate the safety and efficacy of different treatment regimens for hypercholesterolemia. Of all the study participants, 11 patients were evaluated in all 6 clinical trials using the following regimens: neomycin, neomycin/niacin, cholestyramine, cholestyramine/neomycin, lovastatin and lovastatin/neomycin. All 6 regimens significantly (p <0.05) reduced both total and low-density lipoprotein cholesterol concentrations by 25 to 42 % from baseline levels. Only neomycin/niacin, cholestyramine and lovastatin significantly increased the high-density lipoprotein (HDL) cholesterol concentration, reducing the total cholesterol/high-density lipoprotein cholesterol ratio to less than 4.7. Thus, all 6 tested regimens were effective in modifying the plasma lipoprotein concentrations in type 11 hyperlipoproteinemia, but neomydn/niacin, cholestyramine and lovastatin had the most favorable Impact. Only lovastatin treatment was free of adverse effects.

UR - http://www.scopus.com/inward/record.url?scp=0023187504&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0023187504&partnerID=8YFLogxK

U2 - 10.1016/0002-9149(87)91097-6

DO - 10.1016/0002-9149(87)91097-6

M3 - Article

C2 - 3644588

AN - SCOPUS:0023187504

VL - 59

JO - American Journal of Cardiology

JF - American Journal of Cardiology

SN - 0002-9149

IS - 8

ER -