Comparison of presentation and outcome for patients 18 to 40 and 60 to 70 years old with solid renal masses

Michael D. Gillett, John C. Cheville, Robert Jeffrey Karnes, Christine M. Lohse, Eugene D Kwon, Bradley C. Leibovich, Horst Zincke, Michael L. Blute

Research output: Contribution to journalArticle

69 Citations (Scopus)

Abstract

Purpose: We compared histological subtype, pathological features and outcome of patients with solid renal masses who were 18 to 40 years old vs patients who were 60 to 70 years old. Materials and Methods: We conducted a retrospective review of the Mayo Clinic Nephrectomy Registry from 1970 to 2000, and identified 124 patients 18 to 40 years old and 1,067 patients 60 to 70 years old available for analysis. Results: There was no significant difference in the incidence of benign solid renal masses between patients 18 to 40 years old and those 60 to 70 years old (13.7% vs 10.2%). Among patients with renal cell carcinoma (RCC), younger patients were more likely to have chromophobe RCC (13.1% vs 3.6%) and less likely to have clear cell RCC (70.1% vs 81.5%) than older patients. Among patients with clear cell RCC, younger patients were more likely to have stage pT2b or lower tumors (82.7% vs 69.9%) and a higher incidence of cystic clear cell RCC (10.7% vs 2.2%) than older patients. Younger patients had an improved cancer specific survival compared with older patients but this difference was not statistically significant (risk ratio 0.71, p = 0.127). Conclusions: We found that patients 18 to 40 years old were more likely to have chromophobe and less likely to have clear cell RCC compared with patients 60 to 70 years old. We did not identify a higher incidence of papillary RCC in younger patients. Patients with clear cell RCC 18 to 40 years old had a higher incidence of low stage and cystic tumors compared with patients 60 to 70 years old, features which have been shown to have a favorable prognosis. These factors likely contributed to improved cancer specific survival for younger patients.

Original languageEnglish (US)
Pages (from-to)1893-1896
Number of pages4
JournalJournal of Urology
Volume173
Issue number6
DOIs
StatePublished - Jun 2005

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Kidney
Renal Cell Carcinoma
Incidence
Neoplasms
Survival
Nephrectomy
Registries
Odds Ratio

Keywords

  • Adenoma
  • Carcinoma
  • Chromophobe
  • Renal cell

ASJC Scopus subject areas

  • Urology

Cite this

Comparison of presentation and outcome for patients 18 to 40 and 60 to 70 years old with solid renal masses. / Gillett, Michael D.; Cheville, John C.; Karnes, Robert Jeffrey; Lohse, Christine M.; Kwon, Eugene D; Leibovich, Bradley C.; Zincke, Horst; Blute, Michael L.

In: Journal of Urology, Vol. 173, No. 6, 06.2005, p. 1893-1896.

Research output: Contribution to journalArticle

Gillett, Michael D. ; Cheville, John C. ; Karnes, Robert Jeffrey ; Lohse, Christine M. ; Kwon, Eugene D ; Leibovich, Bradley C. ; Zincke, Horst ; Blute, Michael L. / Comparison of presentation and outcome for patients 18 to 40 and 60 to 70 years old with solid renal masses. In: Journal of Urology. 2005 ; Vol. 173, No. 6. pp. 1893-1896.
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abstract = "Purpose: We compared histological subtype, pathological features and outcome of patients with solid renal masses who were 18 to 40 years old vs patients who were 60 to 70 years old. Materials and Methods: We conducted a retrospective review of the Mayo Clinic Nephrectomy Registry from 1970 to 2000, and identified 124 patients 18 to 40 years old and 1,067 patients 60 to 70 years old available for analysis. Results: There was no significant difference in the incidence of benign solid renal masses between patients 18 to 40 years old and those 60 to 70 years old (13.7{\%} vs 10.2{\%}). Among patients with renal cell carcinoma (RCC), younger patients were more likely to have chromophobe RCC (13.1{\%} vs 3.6{\%}) and less likely to have clear cell RCC (70.1{\%} vs 81.5{\%}) than older patients. Among patients with clear cell RCC, younger patients were more likely to have stage pT2b or lower tumors (82.7{\%} vs 69.9{\%}) and a higher incidence of cystic clear cell RCC (10.7{\%} vs 2.2{\%}) than older patients. Younger patients had an improved cancer specific survival compared with older patients but this difference was not statistically significant (risk ratio 0.71, p = 0.127). Conclusions: We found that patients 18 to 40 years old were more likely to have chromophobe and less likely to have clear cell RCC compared with patients 60 to 70 years old. We did not identify a higher incidence of papillary RCC in younger patients. Patients with clear cell RCC 18 to 40 years old had a higher incidence of low stage and cystic tumors compared with patients 60 to 70 years old, features which have been shown to have a favorable prognosis. These factors likely contributed to improved cancer specific survival for younger patients.",
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AU - Gillett, Michael D.

AU - Cheville, John C.

AU - Karnes, Robert Jeffrey

AU - Lohse, Christine M.

AU - Kwon, Eugene D

AU - Leibovich, Bradley C.

AU - Zincke, Horst

AU - Blute, Michael L.

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N2 - Purpose: We compared histological subtype, pathological features and outcome of patients with solid renal masses who were 18 to 40 years old vs patients who were 60 to 70 years old. Materials and Methods: We conducted a retrospective review of the Mayo Clinic Nephrectomy Registry from 1970 to 2000, and identified 124 patients 18 to 40 years old and 1,067 patients 60 to 70 years old available for analysis. Results: There was no significant difference in the incidence of benign solid renal masses between patients 18 to 40 years old and those 60 to 70 years old (13.7% vs 10.2%). Among patients with renal cell carcinoma (RCC), younger patients were more likely to have chromophobe RCC (13.1% vs 3.6%) and less likely to have clear cell RCC (70.1% vs 81.5%) than older patients. Among patients with clear cell RCC, younger patients were more likely to have stage pT2b or lower tumors (82.7% vs 69.9%) and a higher incidence of cystic clear cell RCC (10.7% vs 2.2%) than older patients. Younger patients had an improved cancer specific survival compared with older patients but this difference was not statistically significant (risk ratio 0.71, p = 0.127). Conclusions: We found that patients 18 to 40 years old were more likely to have chromophobe and less likely to have clear cell RCC compared with patients 60 to 70 years old. We did not identify a higher incidence of papillary RCC in younger patients. Patients with clear cell RCC 18 to 40 years old had a higher incidence of low stage and cystic tumors compared with patients 60 to 70 years old, features which have been shown to have a favorable prognosis. These factors likely contributed to improved cancer specific survival for younger patients.

AB - Purpose: We compared histological subtype, pathological features and outcome of patients with solid renal masses who were 18 to 40 years old vs patients who were 60 to 70 years old. Materials and Methods: We conducted a retrospective review of the Mayo Clinic Nephrectomy Registry from 1970 to 2000, and identified 124 patients 18 to 40 years old and 1,067 patients 60 to 70 years old available for analysis. Results: There was no significant difference in the incidence of benign solid renal masses between patients 18 to 40 years old and those 60 to 70 years old (13.7% vs 10.2%). Among patients with renal cell carcinoma (RCC), younger patients were more likely to have chromophobe RCC (13.1% vs 3.6%) and less likely to have clear cell RCC (70.1% vs 81.5%) than older patients. Among patients with clear cell RCC, younger patients were more likely to have stage pT2b or lower tumors (82.7% vs 69.9%) and a higher incidence of cystic clear cell RCC (10.7% vs 2.2%) than older patients. Younger patients had an improved cancer specific survival compared with older patients but this difference was not statistically significant (risk ratio 0.71, p = 0.127). Conclusions: We found that patients 18 to 40 years old were more likely to have chromophobe and less likely to have clear cell RCC compared with patients 60 to 70 years old. We did not identify a higher incidence of papillary RCC in younger patients. Patients with clear cell RCC 18 to 40 years old had a higher incidence of low stage and cystic tumors compared with patients 60 to 70 years old, features which have been shown to have a favorable prognosis. These factors likely contributed to improved cancer specific survival for younger patients.

KW - Adenoma

KW - Carcinoma

KW - Chromophobe

KW - Renal cell

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