Comparison of peripheral blood interphase cytogenetics with bone marrow karyotype analysis in myelofibrosis with myeloid metaplasia

Ayalew Tefferi, Reid G. Meyer, William A. Wyatt, Gordon W. Dewald

Research output: Contribution to journalArticle

29 Scopus citations

Abstract

In a prospective study of 42 patients with myelofibrosis with myeloid metaplasia (MMM), peripheral blood (PB) and bone marrow (BM) interphase cytogenetics and PB CD34 enumeration were performed concomitantly with BM karyotype analysis. Interphase cytogenetics was performed with a panel of fluorescence in situ hybridization (FISH) probes that were capable of detecting most of the known recurrent cytogenetic lesions in MMM. There was a close concordance in the results of interphase cytogenetics between PB and BM, regardless of the PB CD34 count. In general, FISH-detectable abnormalities were also detected by BM karyotype. Although complementary, interphase cytogenetics may not always provide the necessary karyotypic information in MMM.

Original languageEnglish (US)
Pages (from-to)316-319
Number of pages4
JournalBritish journal of haematology
Volume115
Issue number2
DOIs
StatePublished - 2001

Keywords

  • Inter-phase cytogenetics
  • Karyotype
  • Myelofibrosis with myeloid metaplasia
  • Myeloid disorders

ASJC Scopus subject areas

  • Hematology

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