Comparison of non-contrast vessel wall imaging and 3-D time-of-flight MRA for atherosclerotic stenosis and plaque characterization within intracranial arteries

Dong Kun Kim, Jared T. Verdoorn, Tina M. Gunderson, John Huston, Waleed Brinjikji, Giuseppe Lanzino, Vance T Lehman

Research output: Contribution to journalArticle

Abstract

Purpose: We compared the ability of intracranial high-resolution vessel wall imaging (VWI) without gadolinium and 3-D time-of-flight (3D-TOF) MRA techniques to characterize intracranial arterial stenosis and arterial wall plaque consistent with atherosclerotic plaque. Methods: Consecutive intracranial VWI examinations performed within 2 months of a 3D-TOF exam with at least 1 noted plaque was included. Examinations assessed 17 vessel segments for plaque and diameters of stenotic and normal segments using double oblique reformatted images. Results were compared with the VWI and 3D-TOF exams considered the reference standard for plaque and luminal stenosis, respectively. Results: Assessed segments totaled 286 from 17 patients. Proximal segment sensitivity and specificity for luminal stenosis detection with VWI was 92.5% and 82.1%, respectively, whereas for assessing plaque with 3D-TOF it was 59.4% and 98.3%, respectively. The mean intra-rater difference in luminal diameter measurements between VWI and 3D-TOF at normal segments and at the area of maximal stenosis was 0.02 mm (SD 0.51 mm) and 0.08 mm (SD 0.66 mm), respectively. Conclusions: Intracranial VWI demonstrated reasonably high sensitivity and specificity for luminal stenosis assessment using 3D-TOF as a reference standard, while 3D-TOF demonstrated low sensitivity for plaque detection. Our results suggest that VWI can be used for simultaneous assessment of luminal stenosis and plaque in the intracranial arteries.

Original languageEnglish (US)
JournalJournal of Neuroradiology
DOIs
StatePublished - Jan 1 2019

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Three-Dimensional Imaging
Atherosclerotic Plaques
Pathologic Constriction
Arteries
Sensitivity and Specificity
Gadolinium

Keywords

  • Atherosclerosis
  • Magnetic resonance angiogram
  • Magnetic resonance imaging
  • Vessel wall imaging

ASJC Scopus subject areas

  • Radiological and Ultrasound Technology
  • Radiology Nuclear Medicine and imaging
  • Clinical Neurology

Cite this

@article{cf8240b6c3734df6a294778e3205cd45,
title = "Comparison of non-contrast vessel wall imaging and 3-D time-of-flight MRA for atherosclerotic stenosis and plaque characterization within intracranial arteries",
abstract = "Purpose: We compared the ability of intracranial high-resolution vessel wall imaging (VWI) without gadolinium and 3-D time-of-flight (3D-TOF) MRA techniques to characterize intracranial arterial stenosis and arterial wall plaque consistent with atherosclerotic plaque. Methods: Consecutive intracranial VWI examinations performed within 2 months of a 3D-TOF exam with at least 1 noted plaque was included. Examinations assessed 17 vessel segments for plaque and diameters of stenotic and normal segments using double oblique reformatted images. Results were compared with the VWI and 3D-TOF exams considered the reference standard for plaque and luminal stenosis, respectively. Results: Assessed segments totaled 286 from 17 patients. Proximal segment sensitivity and specificity for luminal stenosis detection with VWI was 92.5{\%} and 82.1{\%}, respectively, whereas for assessing plaque with 3D-TOF it was 59.4{\%} and 98.3{\%}, respectively. The mean intra-rater difference in luminal diameter measurements between VWI and 3D-TOF at normal segments and at the area of maximal stenosis was 0.02 mm (SD 0.51 mm) and 0.08 mm (SD 0.66 mm), respectively. Conclusions: Intracranial VWI demonstrated reasonably high sensitivity and specificity for luminal stenosis assessment using 3D-TOF as a reference standard, while 3D-TOF demonstrated low sensitivity for plaque detection. Our results suggest that VWI can be used for simultaneous assessment of luminal stenosis and plaque in the intracranial arteries.",
keywords = "Atherosclerosis, Magnetic resonance angiogram, Magnetic resonance imaging, Vessel wall imaging",
author = "Kim, {Dong Kun} and Verdoorn, {Jared T.} and Gunderson, {Tina M.} and John Huston and Waleed Brinjikji and Giuseppe Lanzino and Lehman, {Vance T}",
year = "2019",
month = "1",
day = "1",
doi = "10.1016/j.neurad.2019.05.003",
language = "English (US)",
journal = "Journal of Neuroradiology",
issn = "0150-9861",
publisher = "Elsevier Masson",

}

TY - JOUR

T1 - Comparison of non-contrast vessel wall imaging and 3-D time-of-flight MRA for atherosclerotic stenosis and plaque characterization within intracranial arteries

AU - Kim, Dong Kun

AU - Verdoorn, Jared T.

AU - Gunderson, Tina M.

AU - Huston, John

AU - Brinjikji, Waleed

AU - Lanzino, Giuseppe

AU - Lehman, Vance T

PY - 2019/1/1

Y1 - 2019/1/1

N2 - Purpose: We compared the ability of intracranial high-resolution vessel wall imaging (VWI) without gadolinium and 3-D time-of-flight (3D-TOF) MRA techniques to characterize intracranial arterial stenosis and arterial wall plaque consistent with atherosclerotic plaque. Methods: Consecutive intracranial VWI examinations performed within 2 months of a 3D-TOF exam with at least 1 noted plaque was included. Examinations assessed 17 vessel segments for plaque and diameters of stenotic and normal segments using double oblique reformatted images. Results were compared with the VWI and 3D-TOF exams considered the reference standard for plaque and luminal stenosis, respectively. Results: Assessed segments totaled 286 from 17 patients. Proximal segment sensitivity and specificity for luminal stenosis detection with VWI was 92.5% and 82.1%, respectively, whereas for assessing plaque with 3D-TOF it was 59.4% and 98.3%, respectively. The mean intra-rater difference in luminal diameter measurements between VWI and 3D-TOF at normal segments and at the area of maximal stenosis was 0.02 mm (SD 0.51 mm) and 0.08 mm (SD 0.66 mm), respectively. Conclusions: Intracranial VWI demonstrated reasonably high sensitivity and specificity for luminal stenosis assessment using 3D-TOF as a reference standard, while 3D-TOF demonstrated low sensitivity for plaque detection. Our results suggest that VWI can be used for simultaneous assessment of luminal stenosis and plaque in the intracranial arteries.

AB - Purpose: We compared the ability of intracranial high-resolution vessel wall imaging (VWI) without gadolinium and 3-D time-of-flight (3D-TOF) MRA techniques to characterize intracranial arterial stenosis and arterial wall plaque consistent with atherosclerotic plaque. Methods: Consecutive intracranial VWI examinations performed within 2 months of a 3D-TOF exam with at least 1 noted plaque was included. Examinations assessed 17 vessel segments for plaque and diameters of stenotic and normal segments using double oblique reformatted images. Results were compared with the VWI and 3D-TOF exams considered the reference standard for plaque and luminal stenosis, respectively. Results: Assessed segments totaled 286 from 17 patients. Proximal segment sensitivity and specificity for luminal stenosis detection with VWI was 92.5% and 82.1%, respectively, whereas for assessing plaque with 3D-TOF it was 59.4% and 98.3%, respectively. The mean intra-rater difference in luminal diameter measurements between VWI and 3D-TOF at normal segments and at the area of maximal stenosis was 0.02 mm (SD 0.51 mm) and 0.08 mm (SD 0.66 mm), respectively. Conclusions: Intracranial VWI demonstrated reasonably high sensitivity and specificity for luminal stenosis assessment using 3D-TOF as a reference standard, while 3D-TOF demonstrated low sensitivity for plaque detection. Our results suggest that VWI can be used for simultaneous assessment of luminal stenosis and plaque in the intracranial arteries.

KW - Atherosclerosis

KW - Magnetic resonance angiogram

KW - Magnetic resonance imaging

KW - Vessel wall imaging

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