@article{f649b3cbb8b241d7b55adaee6ae6373d,
title = "Comparison of neuropathology in Parkinson's disease subjects with and without deep brain stimulation",
abstract = "Background: The aim of this postmortem study was to compare, in Parkinson's disease subjects with and without bilateral subthalamic nucleus deep brain stimulation (STN-DBS), the loss of pigmented neurons within the substantia nigra and pathological alpha-synuclein density within the SN and other brain regions. Methods: PD subjects were identified from the Arizona Study of Aging and Neurodegenerative Disorders database (STN-DBS = 11, non-DBS = 156). Pigmented neuron loss scores within the substantia nigra as well as alpha-synuclein density scores within the substantia nigra and 9 other brain regions were compared, the latter individually and in summary as the Lewy body brain load score. Results: DBS subjects had higher alpha-synuclein density scores within the substantia nigra, olfactory bulb, and locus ceruleus, as well as higher total Lewy body brain load scores when compared with non-DBS subjects. No differences in substantia nigra pigmented neuron loss scores were found. Conclusions: STN-DBS subjects tend to have higher alpha-synuclein density scores, but do not have a differential loss of substantia nigra pigmented neurons.",
keywords = "Lewy body, Parkinson's disease, alpha-synuclein, deep brain stimulation, subthalamic nucleus",
author = "{the Arizona Study of Aging Neurodegenerative Disorders} and Pal, {Gian D.} and Bichun Ouyang and Geidy Serrano and Shill, {Holly A.} and Christopher Goetz and Glenn Stebbins and Metman, {Leo Verhagen} and Erika Driver-Dunckley and Mehta, {Shyamal H.} and Caviness, {John N.} and Sabbagh, {Marwan N.} and Adler, {Charles H.} and Beach, {Thomas G.}",
note = "Funding Information: Data used in the preparation of this article were obtained from the Arizona Study of Aging and Neurodegenerative Disorders (AZSAND) database (www.brainandbodydonationprogram.org). As such, the investigators of AZSAND contributed to the design and implementation of AZSAND and/or provided data, but they did not participate in the analysis or writing of this report. A complete listing of the AZSAND investigators is at the www.brainandbodydonationprogram.org website.The Brain and Body Donation Program is supported by the National Institute of Neurological Disorders and Stroke (U24 NS072026 National Brain and Tissue Resource for Parkinson's Disease and Related Disorders), the National Institute on Aging (P30 AG19610 Arizona Alzheimer's Disease Core Center), the Arizona Department of Health Services (contract 211002, Arizona Alzheimer's Research Center), the Arizona Biomedical Research Commission (contracts 4001, 0011, 05-901, and 1001 to the Arizona Parkinson's Disease Consortium) and the Michael J. Fox Foundation for Parkinson's Research. Publisher Copyright: {\textcopyright} 2016 International Parkinson and Movement Disorder Society",
year = "2017",
month = feb,
day = "1",
doi = "10.1002/mds.26882",
language = "English (US)",
volume = "32",
pages = "274--277",
journal = "Movement Disorders",
issn = "0885-3185",
publisher = "John Wiley and Sons Inc.",
number = "2",
}