Comparison of neuropathology in Parkinson's disease subjects with and without deep brain stimulation

Gian D. Pal, Bichun Ouyang, Geidy Serrano, Holly A. Shill, Christopher Goetz, Glenn Stebbins, Leo Verhagen Metman, Erika M Driver-Dunckley, Shyamal Mehta, John Nathaniel Caviness, Marwan N. Sabbagh, Charles Howard Adler, Thomas G. Beach

Research output: Contribution to journalArticle

9 Scopus citations

Abstract

Background: The aim of this postmortem study was to compare, in Parkinson's disease subjects with and without bilateral subthalamic nucleus deep brain stimulation (STN-DBS), the loss of pigmented neurons within the substantia nigra and pathological alpha-synuclein density within the SN and other brain regions. Methods: PD subjects were identified from the Arizona Study of Aging and Neurodegenerative Disorders database (STN-DBS=11, non-DBS=156). Pigmented neuron loss scores within the substantia nigra as well as alpha-synuclein density scores within the substantia nigra and 9 other brain regions were compared, the latter individually and in summary as the Lewy body brain load score. Results: DBS subjects had higher alpha-synuclein density scores within the substantia nigra, olfactory bulb, and locus ceruleus, as well as higher total Lewy body brain load scores when compared with non-DBS subjects. No differences in substantia nigra pigmented neuron loss scores were found. Conclusions: STN-DBS subjects tend to have higher alpha-synuclein density scores, but do not have a differential loss of substantia nigra pigmented neurons.

Original languageEnglish (US)
JournalMovement Disorders
DOIs
StateAccepted/In press - 2016

Keywords

  • Alpha-synuclein
  • Deep brain stimulation
  • Lewy body
  • Parkinson's disease
  • Subthalamic nucleus

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

Fingerprint Dive into the research topics of 'Comparison of neuropathology in Parkinson's disease subjects with and without deep brain stimulation'. Together they form a unique fingerprint.

  • Cite this

    Pal, G. D., Ouyang, B., Serrano, G., Shill, H. A., Goetz, C., Stebbins, G., Metman, L. V., Driver-Dunckley, E. M., Mehta, S., Caviness, J. N., Sabbagh, M. N., Adler, C. H., & Beach, T. G. (Accepted/In press). Comparison of neuropathology in Parkinson's disease subjects with and without deep brain stimulation. Movement Disorders. https://doi.org/10.1002/mds.26882