Comparison of neuropathology in Parkinson's disease subjects with and without deep brain stimulation

Gian D. Pal, Bichun Ouyang, Geidy Serrano, Holly A. Shill, Christopher Goetz, Glenn Stebbins, Leo Verhagen Metman, Erika M Driver-Dunckley, Shyamal Mehta, John Nathaniel Caviness, Marwan N. Sabbagh, Charles Howard Adler, Thomas G. Beach

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Background: The aim of this postmortem study was to compare, in Parkinson's disease subjects with and without bilateral subthalamic nucleus deep brain stimulation (STN-DBS), the loss of pigmented neurons within the substantia nigra and pathological alpha-synuclein density within the SN and other brain regions. Methods: PD subjects were identified from the Arizona Study of Aging and Neurodegenerative Disorders database (STN-DBS=11, non-DBS=156). Pigmented neuron loss scores within the substantia nigra as well as alpha-synuclein density scores within the substantia nigra and 9 other brain regions were compared, the latter individually and in summary as the Lewy body brain load score. Results: DBS subjects had higher alpha-synuclein density scores within the substantia nigra, olfactory bulb, and locus ceruleus, as well as higher total Lewy body brain load scores when compared with non-DBS subjects. No differences in substantia nigra pigmented neuron loss scores were found. Conclusions: STN-DBS subjects tend to have higher alpha-synuclein density scores, but do not have a differential loss of substantia nigra pigmented neurons.

Original languageEnglish (US)
JournalMovement Disorders
DOIs
StateAccepted/In press - 2016

Fingerprint

Deep Brain Stimulation
Substantia Nigra
Parkinson Disease
alpha-Synuclein
Subthalamic Nucleus
Lewy Bodies
Neurons
Brain
Locus Coeruleus
Olfactory Bulb
Neurodegenerative Diseases
Neuropathology
Databases

Keywords

  • Alpha-synuclein
  • Deep brain stimulation
  • Lewy body
  • Parkinson's disease
  • Subthalamic nucleus

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

Cite this

Pal, G. D., Ouyang, B., Serrano, G., Shill, H. A., Goetz, C., Stebbins, G., ... Beach, T. G. (Accepted/In press). Comparison of neuropathology in Parkinson's disease subjects with and without deep brain stimulation. Movement Disorders. https://doi.org/10.1002/mds.26882

Comparison of neuropathology in Parkinson's disease subjects with and without deep brain stimulation. / Pal, Gian D.; Ouyang, Bichun; Serrano, Geidy; Shill, Holly A.; Goetz, Christopher; Stebbins, Glenn; Metman, Leo Verhagen; Driver-Dunckley, Erika M; Mehta, Shyamal; Caviness, John Nathaniel; Sabbagh, Marwan N.; Adler, Charles Howard; Beach, Thomas G.

In: Movement Disorders, 2016.

Research output: Contribution to journalArticle

Pal, Gian D. ; Ouyang, Bichun ; Serrano, Geidy ; Shill, Holly A. ; Goetz, Christopher ; Stebbins, Glenn ; Metman, Leo Verhagen ; Driver-Dunckley, Erika M ; Mehta, Shyamal ; Caviness, John Nathaniel ; Sabbagh, Marwan N. ; Adler, Charles Howard ; Beach, Thomas G. / Comparison of neuropathology in Parkinson's disease subjects with and without deep brain stimulation. In: Movement Disorders. 2016.
@article{f649b3cbb8b241d7b55adaee6ae6373d,
title = "Comparison of neuropathology in Parkinson's disease subjects with and without deep brain stimulation",
abstract = "Background: The aim of this postmortem study was to compare, in Parkinson's disease subjects with and without bilateral subthalamic nucleus deep brain stimulation (STN-DBS), the loss of pigmented neurons within the substantia nigra and pathological alpha-synuclein density within the SN and other brain regions. Methods: PD subjects were identified from the Arizona Study of Aging and Neurodegenerative Disorders database (STN-DBS=11, non-DBS=156). Pigmented neuron loss scores within the substantia nigra as well as alpha-synuclein density scores within the substantia nigra and 9 other brain regions were compared, the latter individually and in summary as the Lewy body brain load score. Results: DBS subjects had higher alpha-synuclein density scores within the substantia nigra, olfactory bulb, and locus ceruleus, as well as higher total Lewy body brain load scores when compared with non-DBS subjects. No differences in substantia nigra pigmented neuron loss scores were found. Conclusions: STN-DBS subjects tend to have higher alpha-synuclein density scores, but do not have a differential loss of substantia nigra pigmented neurons.",
keywords = "Alpha-synuclein, Deep brain stimulation, Lewy body, Parkinson's disease, Subthalamic nucleus",
author = "Pal, {Gian D.} and Bichun Ouyang and Geidy Serrano and Shill, {Holly A.} and Christopher Goetz and Glenn Stebbins and Metman, {Leo Verhagen} and Driver-Dunckley, {Erika M} and Shyamal Mehta and Caviness, {John Nathaniel} and Sabbagh, {Marwan N.} and Adler, {Charles Howard} and Beach, {Thomas G.}",
year = "2016",
doi = "10.1002/mds.26882",
language = "English (US)",
journal = "Movement Disorders",
issn = "0885-3185",
publisher = "John Wiley and Sons Inc.",

}

TY - JOUR

T1 - Comparison of neuropathology in Parkinson's disease subjects with and without deep brain stimulation

AU - Pal, Gian D.

AU - Ouyang, Bichun

AU - Serrano, Geidy

AU - Shill, Holly A.

AU - Goetz, Christopher

AU - Stebbins, Glenn

AU - Metman, Leo Verhagen

AU - Driver-Dunckley, Erika M

AU - Mehta, Shyamal

AU - Caviness, John Nathaniel

AU - Sabbagh, Marwan N.

AU - Adler, Charles Howard

AU - Beach, Thomas G.

PY - 2016

Y1 - 2016

N2 - Background: The aim of this postmortem study was to compare, in Parkinson's disease subjects with and without bilateral subthalamic nucleus deep brain stimulation (STN-DBS), the loss of pigmented neurons within the substantia nigra and pathological alpha-synuclein density within the SN and other brain regions. Methods: PD subjects were identified from the Arizona Study of Aging and Neurodegenerative Disorders database (STN-DBS=11, non-DBS=156). Pigmented neuron loss scores within the substantia nigra as well as alpha-synuclein density scores within the substantia nigra and 9 other brain regions were compared, the latter individually and in summary as the Lewy body brain load score. Results: DBS subjects had higher alpha-synuclein density scores within the substantia nigra, olfactory bulb, and locus ceruleus, as well as higher total Lewy body brain load scores when compared with non-DBS subjects. No differences in substantia nigra pigmented neuron loss scores were found. Conclusions: STN-DBS subjects tend to have higher alpha-synuclein density scores, but do not have a differential loss of substantia nigra pigmented neurons.

AB - Background: The aim of this postmortem study was to compare, in Parkinson's disease subjects with and without bilateral subthalamic nucleus deep brain stimulation (STN-DBS), the loss of pigmented neurons within the substantia nigra and pathological alpha-synuclein density within the SN and other brain regions. Methods: PD subjects were identified from the Arizona Study of Aging and Neurodegenerative Disorders database (STN-DBS=11, non-DBS=156). Pigmented neuron loss scores within the substantia nigra as well as alpha-synuclein density scores within the substantia nigra and 9 other brain regions were compared, the latter individually and in summary as the Lewy body brain load score. Results: DBS subjects had higher alpha-synuclein density scores within the substantia nigra, olfactory bulb, and locus ceruleus, as well as higher total Lewy body brain load scores when compared with non-DBS subjects. No differences in substantia nigra pigmented neuron loss scores were found. Conclusions: STN-DBS subjects tend to have higher alpha-synuclein density scores, but do not have a differential loss of substantia nigra pigmented neurons.

KW - Alpha-synuclein

KW - Deep brain stimulation

KW - Lewy body

KW - Parkinson's disease

KW - Subthalamic nucleus

UR - http://www.scopus.com/inward/record.url?scp=85006138312&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85006138312&partnerID=8YFLogxK

U2 - 10.1002/mds.26882

DO - 10.1002/mds.26882

M3 - Article

C2 - 27911008

AN - SCOPUS:85006138312

JO - Movement Disorders

JF - Movement Disorders

SN - 0885-3185

ER -