Comparison of memory fMRI response among normal, MCI, and Alzheimer's patients

Mary Margaret Machulda, H. A. Ward, B. Borowski, J. L. Gunter, R. H. Cha, P. C. O'Brien, Ronald Carl Petersen, Bradley F Boeve, David S Knopman, D. F. Tang-Wai, R. J. Ivnik, G. E. Smith, Eric George Tangalos, Clifford R Jr. Jack

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Abstract

Objective: To determine whether an fMRI memory encoding task distinguishes among cognitively normal elderly individuals, patients with mild cognitive impairment (MCI), and patients with early Alzheimer's disease (AD). Methods: Twenty-nine subjects (11 normal, 9 MCI, 9 AD) were studied with an fMRI memory encoding task. A passive sensory task was also performed to assess potential intergroup differences in fMRI responsiveness. Activation in the medial temporal lobe for the memory task and in the anatomic rolandic area for the sensory task was studied. Intergroup comparisons were performed using receiver operating characteristic (ROC) analyses. The ROC method provides rigorous control of artifactual false-positive "activation." Subjects were tested for recall and recognition of the encoding task stimuli following the fMRI study. Results: Medial temporal lobe activation was greater in subjects than MCI and AD patients (p = 0.03 and p = 0.04). There was no difference between AD and MCI patients in normal fMRI memory performance. There was an association between fMRI memory activation (area under the ROC curve) and post-fMRI performance on recognition and free recall. There was no difference among the three groups on the sensory task. Conclusions: MCI and AD patients had less medial temporal lobe activation on the memory task than the normal subjects but similar activation as normal subjects on the sensory task. These findings suggest decreased medial temporal activation may be a specific marker of limbic dysfunction due to the neurodegenerative changes of AD. In addition, fMRI is sufficiently sensitive to detect changes in the prodromal, MCI, phase of the disease.

Original languageEnglish (US)
Pages (from-to)500-506
Number of pages7
JournalNeurology
Volume61
Issue number4
StatePublished - Aug 26 2003

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Magnetic Resonance Imaging
Alzheimer Disease
Temporal Lobe
ROC Curve
Cognitive Dysfunction

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Machulda, M. M., Ward, H. A., Borowski, B., Gunter, J. L., Cha, R. H., O'Brien, P. C., ... Jack, C. R. J. (2003). Comparison of memory fMRI response among normal, MCI, and Alzheimer's patients. Neurology, 61(4), 500-506.

Comparison of memory fMRI response among normal, MCI, and Alzheimer's patients. / Machulda, Mary Margaret; Ward, H. A.; Borowski, B.; Gunter, J. L.; Cha, R. H.; O'Brien, P. C.; Petersen, Ronald Carl; Boeve, Bradley F; Knopman, David S; Tang-Wai, D. F.; Ivnik, R. J.; Smith, G. E.; Tangalos, Eric George; Jack, Clifford R Jr.

In: Neurology, Vol. 61, No. 4, 26.08.2003, p. 500-506.

Research output: Contribution to journalArticle

Machulda, MM, Ward, HA, Borowski, B, Gunter, JL, Cha, RH, O'Brien, PC, Petersen, RC, Boeve, BF, Knopman, DS, Tang-Wai, DF, Ivnik, RJ, Smith, GE, Tangalos, EG & Jack, CRJ 2003, 'Comparison of memory fMRI response among normal, MCI, and Alzheimer's patients', Neurology, vol. 61, no. 4, pp. 500-506.
Machulda MM, Ward HA, Borowski B, Gunter JL, Cha RH, O'Brien PC et al. Comparison of memory fMRI response among normal, MCI, and Alzheimer's patients. Neurology. 2003 Aug 26;61(4):500-506.
Machulda, Mary Margaret ; Ward, H. A. ; Borowski, B. ; Gunter, J. L. ; Cha, R. H. ; O'Brien, P. C. ; Petersen, Ronald Carl ; Boeve, Bradley F ; Knopman, David S ; Tang-Wai, D. F. ; Ivnik, R. J. ; Smith, G. E. ; Tangalos, Eric George ; Jack, Clifford R Jr. / Comparison of memory fMRI response among normal, MCI, and Alzheimer's patients. In: Neurology. 2003 ; Vol. 61, No. 4. pp. 500-506.
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AU - Cha, R. H.

AU - O'Brien, P. C.

AU - Petersen, Ronald Carl

AU - Boeve, Bradley F

AU - Knopman, David S

AU - Tang-Wai, D. F.

AU - Ivnik, R. J.

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AU - Tangalos, Eric George

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