Comparison of longitudinal variance components and regression-based approaches for linkage detection on chromosome 17 for systolic blood pressure.

Mariza de Andrade, Curtis Olswold

Research output: Contribution to journalArticlepeer-review

5 Scopus citations

Abstract

We compare two methods to detect genetic linkage by using serial observations of systolic blood pressure in pedigree data from the Framingham Heart Study focusing on chromosome 17. The first method is a variance components (VC) approach that incorporates longitudinal pedigree data, and the second method is a regression-based approach that summarizes all longitudinal measures in one single measure. No evidence of linkage was found either using the VC longitudinal approach or the regression-based approach, except when all time points were used from Cohorts 1 and 2 and only subjects aged 25 and 75 years were included.

Original languageEnglish (US)
JournalBMC genetics
Volume4 Suppl 1
StatePublished - 2003

ASJC Scopus subject areas

  • Genetics
  • Genetics(clinical)

Fingerprint Dive into the research topics of 'Comparison of longitudinal variance components and regression-based approaches for linkage detection on chromosome 17 for systolic blood pressure.'. Together they form a unique fingerprint.

Cite this