TY - JOUR
T1 - Comparison of graft-versus-host-disease and survival after HLA-identical sibling bone marrow transplantation in ethnic populations
AU - Oh, Hakumei
AU - Loberiza, Fausto R.
AU - Zhang, Mei Jie
AU - Ringdén, Olle
AU - Akiyama, Hideki
AU - Asai, Takayoshi
AU - Miyawaki, Shuichi
AU - Okamoto, Shinichiro
AU - Horowitz, Mary M.
AU - Antin, Joseph H.
AU - Bashey, Asad
AU - Bird, Jennifer M.
AU - Carabasi, Matthew H.
AU - Fay, Joseph W.
AU - Gale, Robert Peter
AU - Giller, Roger H.
AU - Goldman, John M.
AU - Hale, Gregory A.
AU - Harris, Richard E.
AU - Henslee-Downey, Jean
AU - Kolb, Hans Jochem
AU - Litzow, Mark R.
AU - McCarthy, Philip L.
AU - Neudorf, Steven M.
AU - Serna, Derek S.
AU - Socié, Gerard
AU - Tiberghien, Pierre
AU - Barrett, A. John
PY - 2005/2/15
Y1 - 2005/2/15
N2 - The association of ethinicity with the incidence of graft-versus-host disease (GVHD) and other clinical outcomes after transplantation is controversial. We compared the results of HLA-identical sibling bone marrow transplantations for leukemia, performed between 1990 and 1999, among different ethnic populations, including 562 Japanese, 829 white Americans, 71 African Americans, 195 Scandinavians, and 95 Irish. Results for adults and children were analyzed separately. Multivariate analyses of adult patients showed that white Americans, African Americans, and Irish cohorts were at significantly higher risk for acute GVHD than Japanese or Scandinavian cohorts (relative risk [RR] = 1.77, P < .001; RR = 1.84, P < .006; RR = 2.22, P < .001, respectively). White Americans, African Americans, and Irish, but not Scandinavians, were at significantly higher risk for early (within 3 months of transplantation) transplant-related mortality (TRM) compared with Japanese (RR = 2.99, P < .001; RR = 5.88, P < .001; RR = 2.66, P < .009, respectively). No differences in the risk for chronic GVHD, relapse, and overall survival were noted. In the pediatric cohort (limited to Japanese and white Americans), white Americans were at significantly higher risk for acute (RR = 1.93; P = .04) and chronic (RR = 3.16; P = .002) GVHD. No differences in other clinical outcomes were noted. Our findings suggest that ethnicity may influence the risk for GVHD, though overall survival rates after transplantation remain similar.
AB - The association of ethinicity with the incidence of graft-versus-host disease (GVHD) and other clinical outcomes after transplantation is controversial. We compared the results of HLA-identical sibling bone marrow transplantations for leukemia, performed between 1990 and 1999, among different ethnic populations, including 562 Japanese, 829 white Americans, 71 African Americans, 195 Scandinavians, and 95 Irish. Results for adults and children were analyzed separately. Multivariate analyses of adult patients showed that white Americans, African Americans, and Irish cohorts were at significantly higher risk for acute GVHD than Japanese or Scandinavian cohorts (relative risk [RR] = 1.77, P < .001; RR = 1.84, P < .006; RR = 2.22, P < .001, respectively). White Americans, African Americans, and Irish, but not Scandinavians, were at significantly higher risk for early (within 3 months of transplantation) transplant-related mortality (TRM) compared with Japanese (RR = 2.99, P < .001; RR = 5.88, P < .001; RR = 2.66, P < .009, respectively). No differences in the risk for chronic GVHD, relapse, and overall survival were noted. In the pediatric cohort (limited to Japanese and white Americans), white Americans were at significantly higher risk for acute (RR = 1.93; P = .04) and chronic (RR = 3.16; P = .002) GVHD. No differences in other clinical outcomes were noted. Our findings suggest that ethnicity may influence the risk for GVHD, though overall survival rates after transplantation remain similar.
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U2 - 10.1182/blood-2004-06-2385
DO - 10.1182/blood-2004-06-2385
M3 - Article
C2 - 15486071
AN - SCOPUS:13544250493
SN - 0006-4971
VL - 105
SP - 1408
EP - 1416
JO - Blood
JF - Blood
IS - 4
ER -