Comparison of four computerized models to estimate 24-hour growth hormone secretion in girls with turner's syndrome

Manon M. Kuilboer, Bart Kleijer, Gerdine A. Kamp, Johannes D. Veldhuis, Michael L. Johnson, Jan Maarten Wit

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

Daily pituitary growth hormone (GH) secretion can be estimated from a 24- hour GH profile by various methods. We have used four methods to assess GH secretion in 36 girls with Turner’s syndrome: the method described by Thompson et al., the Pulsar algorithm combined with the method of Heilman et al. and two deconvolution techniques. The number of detected peaks varied considerably among the methods. The mean (± SD) total daily secretion per square meter body surface was 0.53 (0.19) U/m2-day by deconvolution, in contrast to 0.31 (0.17) with the Heilman method and 1.06 (0.37) according to Thompson. The differences are explained by different assumptions about the metabolic clearance rate and various methodological aspects. Assuming a degradation rate of 50%, the growth hormone substitution dosage would be 1- 2 IU/m2-day in GH-deficient children. The usual dosage in girls with Turner’s syndrome is expected to lead to serum GH levels approximately 4 times higher than in the untreated state.

Original languageEnglish (US)
Pages (from-to)125-133
Number of pages9
JournalHormone Research in Paediatrics
Volume38
Issue number3-4
DOIs
StatePublished - 1992

Keywords

  • Deconvolution analysis
  • Growth
  • Growth failure
  • Growth hormone secretion
  • Turner’s syndrome

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

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