Comparison of fatty acid tracers FTHA and BMIPP during myocardial ischemia and hypoxia

Britta Renstrom, Stephen Rommelfanger, Charles K. Stone, Timothy R DeGrado, Khristen J. Carlson, Emanuel Scarbrough, Robert J. Nickles, A. James Liedtke, James E. Holden

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

To study the sensitivity of two fatty acid tracers to changes in beta- oxidation, the myocardial retention kinetics of 125I-iodine-15(p- iodophenyl)-3(R,S)-methylpentadecanoic acid (BMIPP) and 14 18F-fluoro-6- thia-heptadecanoic acid (FTHA) were compared in states of oxygen deprivation due to ischemia and hypoxia. Methods: Nineteen swine were studied by extracorporeal perfusion of the three coronary arteries. Fatty acid beta- oxidation rates were determined by infusion of tritiated palmitate into the left anterior descending artery (LAD) and by measurement of labeled water production in the LAD perfusion bed. After a baseline period of 30 min, animals were divided into three groups and subjected to a 50-min intervention period. For the control group, there was no change in perfusion; for the ischemia group, there was a 60% decrease in LAD perfusion; and for the hypoxia group, the perfusion rate was unchanged, but venous blood was used as the LAD perfusate. Continuous infusion of FTHA and BMIPP into the LAD started 10 min into the intervention period and continued until the end of the intervention period. Retention rates of the two tracers were compared between the LAD and circumflex perfusion beds. Results: No difference in beta- oxidation rate occurred from the baseline to the intervention period in the control group. A 50% reduction in beta-oxidation occurred in the ischemia group, and an 80% reduction occurred in the hypoxia group. No difference in retention of BMIPP or FTHA occurred in the control group. In the ischemia group, reduction in retention of both tracers occurred. However, in the hypoxia group, FTHA uptake was unchanged, whereas BMIPP retention increased compared to the circumflex arterial bed. Conclusion: Decreased retention of both BMIPP and FTHA occurred with ischemia, despite the known differences in metabolism of the two tracers. This difference in metabolism was further highlighted in the setting of hypoxia with increased BMIPP uptake. Thus, these results suggest that uptake of both FTHA and BMIPP tracks reduction of fatty acid utilization in myocardial ischemia but fails in tracking reduction of fatty acid oxidation during hypoxia.

Original languageEnglish (US)
Pages (from-to)1684-1689
Number of pages6
JournalJournal of Nuclear Medicine
Volume39
Issue number10
StatePublished - Oct 1998
Externally publishedYes

Fingerprint

Myocardial Ischemia
Fatty Acids
Arteries
Perfusion
Ischemia
Control Groups
Palmitates
margaric acid
iodofiltic acid
Hypoxia
Iodine
Coronary Vessels
Swine
Oxygen
Acids
Water

Keywords

  • BMIPP
  • Fatty acid tracer
  • FTHA
  • Myocardial hypoxia
  • Myocardial ischemia

ASJC Scopus subject areas

  • Radiological and Ultrasound Technology

Cite this

Renstrom, B., Rommelfanger, S., Stone, C. K., DeGrado, T. R., Carlson, K. J., Scarbrough, E., ... Holden, J. E. (1998). Comparison of fatty acid tracers FTHA and BMIPP during myocardial ischemia and hypoxia. Journal of Nuclear Medicine, 39(10), 1684-1689.

Comparison of fatty acid tracers FTHA and BMIPP during myocardial ischemia and hypoxia. / Renstrom, Britta; Rommelfanger, Stephen; Stone, Charles K.; DeGrado, Timothy R; Carlson, Khristen J.; Scarbrough, Emanuel; Nickles, Robert J.; Liedtke, A. James; Holden, James E.

In: Journal of Nuclear Medicine, Vol. 39, No. 10, 10.1998, p. 1684-1689.

Research output: Contribution to journalArticle

Renstrom, B, Rommelfanger, S, Stone, CK, DeGrado, TR, Carlson, KJ, Scarbrough, E, Nickles, RJ, Liedtke, AJ & Holden, JE 1998, 'Comparison of fatty acid tracers FTHA and BMIPP during myocardial ischemia and hypoxia', Journal of Nuclear Medicine, vol. 39, no. 10, pp. 1684-1689.
Renstrom B, Rommelfanger S, Stone CK, DeGrado TR, Carlson KJ, Scarbrough E et al. Comparison of fatty acid tracers FTHA and BMIPP during myocardial ischemia and hypoxia. Journal of Nuclear Medicine. 1998 Oct;39(10):1684-1689.
Renstrom, Britta ; Rommelfanger, Stephen ; Stone, Charles K. ; DeGrado, Timothy R ; Carlson, Khristen J. ; Scarbrough, Emanuel ; Nickles, Robert J. ; Liedtke, A. James ; Holden, James E. / Comparison of fatty acid tracers FTHA and BMIPP during myocardial ischemia and hypoxia. In: Journal of Nuclear Medicine. 1998 ; Vol. 39, No. 10. pp. 1684-1689.
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abstract = "To study the sensitivity of two fatty acid tracers to changes in beta- oxidation, the myocardial retention kinetics of 125I-iodine-15(p- iodophenyl)-3(R,S)-methylpentadecanoic acid (BMIPP) and 14 18F-fluoro-6- thia-heptadecanoic acid (FTHA) were compared in states of oxygen deprivation due to ischemia and hypoxia. Methods: Nineteen swine were studied by extracorporeal perfusion of the three coronary arteries. Fatty acid beta- oxidation rates were determined by infusion of tritiated palmitate into the left anterior descending artery (LAD) and by measurement of labeled water production in the LAD perfusion bed. After a baseline period of 30 min, animals were divided into three groups and subjected to a 50-min intervention period. For the control group, there was no change in perfusion; for the ischemia group, there was a 60{\%} decrease in LAD perfusion; and for the hypoxia group, the perfusion rate was unchanged, but venous blood was used as the LAD perfusate. Continuous infusion of FTHA and BMIPP into the LAD started 10 min into the intervention period and continued until the end of the intervention period. Retention rates of the two tracers were compared between the LAD and circumflex perfusion beds. Results: No difference in beta- oxidation rate occurred from the baseline to the intervention period in the control group. A 50{\%} reduction in beta-oxidation occurred in the ischemia group, and an 80{\%} reduction occurred in the hypoxia group. No difference in retention of BMIPP or FTHA occurred in the control group. In the ischemia group, reduction in retention of both tracers occurred. However, in the hypoxia group, FTHA uptake was unchanged, whereas BMIPP retention increased compared to the circumflex arterial bed. Conclusion: Decreased retention of both BMIPP and FTHA occurred with ischemia, despite the known differences in metabolism of the two tracers. This difference in metabolism was further highlighted in the setting of hypoxia with increased BMIPP uptake. Thus, these results suggest that uptake of both FTHA and BMIPP tracks reduction of fatty acid utilization in myocardial ischemia but fails in tracking reduction of fatty acid oxidation during hypoxia.",
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author = "Britta Renstrom and Stephen Rommelfanger and Stone, {Charles K.} and DeGrado, {Timothy R} and Carlson, {Khristen J.} and Emanuel Scarbrough and Nickles, {Robert J.} and Liedtke, {A. James} and Holden, {James E.}",
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T1 - Comparison of fatty acid tracers FTHA and BMIPP during myocardial ischemia and hypoxia

AU - Renstrom, Britta

AU - Rommelfanger, Stephen

AU - Stone, Charles K.

AU - DeGrado, Timothy R

AU - Carlson, Khristen J.

AU - Scarbrough, Emanuel

AU - Nickles, Robert J.

AU - Liedtke, A. James

AU - Holden, James E.

PY - 1998/10

Y1 - 1998/10

N2 - To study the sensitivity of two fatty acid tracers to changes in beta- oxidation, the myocardial retention kinetics of 125I-iodine-15(p- iodophenyl)-3(R,S)-methylpentadecanoic acid (BMIPP) and 14 18F-fluoro-6- thia-heptadecanoic acid (FTHA) were compared in states of oxygen deprivation due to ischemia and hypoxia. Methods: Nineteen swine were studied by extracorporeal perfusion of the three coronary arteries. Fatty acid beta- oxidation rates were determined by infusion of tritiated palmitate into the left anterior descending artery (LAD) and by measurement of labeled water production in the LAD perfusion bed. After a baseline period of 30 min, animals were divided into three groups and subjected to a 50-min intervention period. For the control group, there was no change in perfusion; for the ischemia group, there was a 60% decrease in LAD perfusion; and for the hypoxia group, the perfusion rate was unchanged, but venous blood was used as the LAD perfusate. Continuous infusion of FTHA and BMIPP into the LAD started 10 min into the intervention period and continued until the end of the intervention period. Retention rates of the two tracers were compared between the LAD and circumflex perfusion beds. Results: No difference in beta- oxidation rate occurred from the baseline to the intervention period in the control group. A 50% reduction in beta-oxidation occurred in the ischemia group, and an 80% reduction occurred in the hypoxia group. No difference in retention of BMIPP or FTHA occurred in the control group. In the ischemia group, reduction in retention of both tracers occurred. However, in the hypoxia group, FTHA uptake was unchanged, whereas BMIPP retention increased compared to the circumflex arterial bed. Conclusion: Decreased retention of both BMIPP and FTHA occurred with ischemia, despite the known differences in metabolism of the two tracers. This difference in metabolism was further highlighted in the setting of hypoxia with increased BMIPP uptake. Thus, these results suggest that uptake of both FTHA and BMIPP tracks reduction of fatty acid utilization in myocardial ischemia but fails in tracking reduction of fatty acid oxidation during hypoxia.

AB - To study the sensitivity of two fatty acid tracers to changes in beta- oxidation, the myocardial retention kinetics of 125I-iodine-15(p- iodophenyl)-3(R,S)-methylpentadecanoic acid (BMIPP) and 14 18F-fluoro-6- thia-heptadecanoic acid (FTHA) were compared in states of oxygen deprivation due to ischemia and hypoxia. Methods: Nineteen swine were studied by extracorporeal perfusion of the three coronary arteries. Fatty acid beta- oxidation rates were determined by infusion of tritiated palmitate into the left anterior descending artery (LAD) and by measurement of labeled water production in the LAD perfusion bed. After a baseline period of 30 min, animals were divided into three groups and subjected to a 50-min intervention period. For the control group, there was no change in perfusion; for the ischemia group, there was a 60% decrease in LAD perfusion; and for the hypoxia group, the perfusion rate was unchanged, but venous blood was used as the LAD perfusate. Continuous infusion of FTHA and BMIPP into the LAD started 10 min into the intervention period and continued until the end of the intervention period. Retention rates of the two tracers were compared between the LAD and circumflex perfusion beds. Results: No difference in beta- oxidation rate occurred from the baseline to the intervention period in the control group. A 50% reduction in beta-oxidation occurred in the ischemia group, and an 80% reduction occurred in the hypoxia group. No difference in retention of BMIPP or FTHA occurred in the control group. In the ischemia group, reduction in retention of both tracers occurred. However, in the hypoxia group, FTHA uptake was unchanged, whereas BMIPP retention increased compared to the circumflex arterial bed. Conclusion: Decreased retention of both BMIPP and FTHA occurred with ischemia, despite the known differences in metabolism of the two tracers. This difference in metabolism was further highlighted in the setting of hypoxia with increased BMIPP uptake. Thus, these results suggest that uptake of both FTHA and BMIPP tracks reduction of fatty acid utilization in myocardial ischemia but fails in tracking reduction of fatty acid oxidation during hypoxia.

KW - BMIPP

KW - Fatty acid tracer

KW - FTHA

KW - Myocardial hypoxia

KW - Myocardial ischemia

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