Comparison of endoscopic treatment modalities for Barrett's neoplasia

Waseem J. David, Bashar J. Qumseya, Yazen Qumsiyeh, Michael G. Heckman, Nancy N. Diehl, Michael B. Wallace, Massimo Raimondo, Timothy A. Woodward, Herbert C. Wolfsen

Research output: Contribution to journalArticle

5 Scopus citations

Abstract

Background There are few data comparing endoscopic treatment outcomes for Barrett's esophagus (BE). Objective To compare treatment outcomes in BE patients treated with radiofrequency ablation (RFA), RFA after EMR, and porfimer sodium photodynamic therapy (Ps-PDT). Design Retrospective, observational study. Setting Single tertiary center between 2001 and 2013. Patients A total of 342 BE patients treated with RFA (n = 119), EMR+RFA (n = 98), and Ps-PDT (n = 125). Main Outcome Measurements Rates of complete remission of intestinal metaplasia (CRIM), BE recurrence, and adverse events. Results Baseline BE high-grade dysplasia (HGD) and adenocarcinoma were more common in the Ps-PDT group (89%) compared with the EMR-RFA (70%) and RFA (37%) groups. At a median follow-up of 14.2 months, 173 patients (50.6%) achieved CRIM. CRIM was significantly more common in Ps-PDT patients compared with RFA (P

Original languageEnglish (US)
Pages (from-to)793-803e3
JournalGastrointestinal Endoscopy
Volume82
Issue number5
DOIs
StatePublished - Nov 1 2015

    Fingerprint

ASJC Scopus subject areas

  • Gastroenterology
  • Radiology Nuclear Medicine and imaging

Cite this

David, W. J., Qumseya, B. J., Qumsiyeh, Y., Heckman, M. G., Diehl, N. N., Wallace, M. B., Raimondo, M., Woodward, T. A., & Wolfsen, H. C. (2015). Comparison of endoscopic treatment modalities for Barrett's neoplasia. Gastrointestinal Endoscopy, 82(5), 793-803e3. https://doi.org/10.1016/j.gie.2015.03.1979