TY - JOUR
T1 - Comparison of efficacy and safety of leptin replacement therapy in moderately and severely hypoleptinemic patients with familial partial lipodystrophy of the dunnigan variety
AU - Simha, Vinaya
AU - Subramanyam, Lalitha
AU - Szczepaniak, Lidia
AU - Quittner, Claudia
AU - Adams-Huet, Beverley
AU - Snell, Peter
AU - Garg, Abhimanyu
PY - 2012/3
Y1 - 2012/3
N2 - Context: Leptin replacement therapy improves metabolic complications in patients with lipodystrophy and severe hypoleptinemia (SH), but whether the response is related to the degree of hypoleptinemia remains unclear. Objective: The aim of the study was to compare efficacy of leptin therapy in familial partial lipodystrophy, Dunnigan variety (FPLD) patients with SH (serum leptin <7th percentile of normal) vs. those with moderate hypoleptinemia (MH; serum leptin in 7th to 20th percentiles). Design, Setting, and Patients: We conducted an open-label, parallel group, observational study in 14 SH (mean±SD, serum leptin, 1.9±1.1 ng/ml) and 10MH(serum leptin, 5.3±1.0 ng/ml) women with FPLD. Intervention: Patients received 0.08 mg/kg · d of metreleptin by twice daily sc injections for 6 months. Main Outcome Measures: The primary outcome variable was change in fasting serum triglycerides. Other secondary variables were fasting plasma glucose and insulin, insulin sensitivity, hemoglobin A1c, and hepatic triglyceride content. Results: Median fasting serum triglycerides decreased from 228 to 183 mg/dl in the SH group (P = 0.04) and from 423 to 339 mg/dl in the MH group (P = 0.02), but with no difference between the groups (P value for interaction = 0.96). Hepatic triglyceride levels similarly declined significantly from 8.8 to 4.9% in the SH group and from 23.7 to 9.2% in the MH group (P value for interaction= 0.9). Loss of body weight and body fat occurred in both groups. Fasting glucose, insulin, glucose tolerance, and hemoglobin A1c levels did not change. K value on insulin tolerance test improved slightly in the SH group (0.98 to 1.24%; P = 0.01), but not in the MH group (1.1 to 1.27%; P = 0.4). Conclusion: Metreleptin replacement therapy is equally effective in FPLD patients with both SH and MH in reducing serum and hepatic triglyceride levels, but did not improve hyperglycemia.
AB - Context: Leptin replacement therapy improves metabolic complications in patients with lipodystrophy and severe hypoleptinemia (SH), but whether the response is related to the degree of hypoleptinemia remains unclear. Objective: The aim of the study was to compare efficacy of leptin therapy in familial partial lipodystrophy, Dunnigan variety (FPLD) patients with SH (serum leptin <7th percentile of normal) vs. those with moderate hypoleptinemia (MH; serum leptin in 7th to 20th percentiles). Design, Setting, and Patients: We conducted an open-label, parallel group, observational study in 14 SH (mean±SD, serum leptin, 1.9±1.1 ng/ml) and 10MH(serum leptin, 5.3±1.0 ng/ml) women with FPLD. Intervention: Patients received 0.08 mg/kg · d of metreleptin by twice daily sc injections for 6 months. Main Outcome Measures: The primary outcome variable was change in fasting serum triglycerides. Other secondary variables were fasting plasma glucose and insulin, insulin sensitivity, hemoglobin A1c, and hepatic triglyceride content. Results: Median fasting serum triglycerides decreased from 228 to 183 mg/dl in the SH group (P = 0.04) and from 423 to 339 mg/dl in the MH group (P = 0.02), but with no difference between the groups (P value for interaction = 0.96). Hepatic triglyceride levels similarly declined significantly from 8.8 to 4.9% in the SH group and from 23.7 to 9.2% in the MH group (P value for interaction= 0.9). Loss of body weight and body fat occurred in both groups. Fasting glucose, insulin, glucose tolerance, and hemoglobin A1c levels did not change. K value on insulin tolerance test improved slightly in the SH group (0.98 to 1.24%; P = 0.01), but not in the MH group (1.1 to 1.27%; P = 0.4). Conclusion: Metreleptin replacement therapy is equally effective in FPLD patients with both SH and MH in reducing serum and hepatic triglyceride levels, but did not improve hyperglycemia.
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U2 - 10.1210/jc.2011-2229
DO - 10.1210/jc.2011-2229
M3 - Article
C2 - 22170723
AN - SCOPUS:84858027751
SN - 0021-972X
VL - 97
SP - 785
EP - 792
JO - Journal of Clinical Endocrinology and Metabolism
JF - Journal of Clinical Endocrinology and Metabolism
IS - 3
ER -