Comparison of complications during percutaneous transluminal coronary angioplasty from 1977 to 1981 and from 1985 to 1986: The National Heart, Lung, and Blood Institute Percutaneous Transluminal Coronary Angioplasty Registry

David R. Holmes, Richard Holubkov, Ronald E. Vlietstra, Sheryl F. Kelsey, Guy S. Reeder, Gerald Dorros, David O. Williams, Michael J. Cowley, David P. Faxon, Kenneth M. Kent, Lamberto G. Bentivoglio, Katherine Detre

Research output: Contribution to journalArticlepeer-review

273 Scopus citations

Abstract

Because the effects of changing technology in percutaneous transluminal coronary angioplasty, increased operator experience and use of the procedure in patients with extensive disease are unknown in regard to complication patterns, the initial 1977-1981 cohort and the recent 1985-1986 cohort of the National Heart, Lung, and Blood Institute Percutaneous Transluminal Coronary Angioplasty Registry were analyzed with respect to complications. Compared with the initial cohort of 1.155 patients, the 1,801 new cohort patients were older and had an increased prevalence of multivessel coronary artery disease, depressed left ventricular function and prior infarction. Overall complication rates in the recent cohort were either unchanged or decreased from the rates in the initial cohort despite a higher risk patient population. The most significant decreases were in the incidence of coronary spasm (p < 0.001, and the need for emergency coronary bypass surgery (p < 0.01). Overall in-hospital mortality was low but was dependent on the extent of vessel disease-0.2% for single vessel disease, 0.9% for double vessel disease and 2.2% for triple vessel disease (p < 0.001 for linear trend). Acute coronary complications of branch occlusion, dissection or abrupt closure were associated with increased rates of death, nonfatal infarction or need for emergency surgery. Factors showing a multivariate association with increased mortality included a history of congestive heart failure (p < 0.001), age ≥65 years (p < 0.01), triple vessel or left main coronary artery disease (p < 0.05), female gender (p < 0.05) and new onset angina. These data support the concept that, although coronary angioplasty is used in an increased number of patients with more extensive disease, its effectiveness has improved; the procedure, however, has an associated complication rate that, although small, is not negligible.

Original languageEnglish (US)
Pages (from-to)1149-1155
Number of pages7
JournalJournal of the American College of Cardiology
Volume12
Issue number5
DOIs
StatePublished - Nov 1988

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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