Comparison of Combination Therapy of Adenosine and Nitroprusside with Adenosine Alone in the Treatment of Angiographic No-Reflow Phenomenon

Cem Barcin, Ali E. Denktas, Ryan J. Lennon, La Von Hammes, Stuart T. Higano, David R. Holmes, Kirk N. Garratt, Amir Lerman

Research output: Contribution to journalArticlepeer-review

44 Scopus citations

Abstract

We sought to compare the combination therapy of adenosine and nitroprusside in no-reflow phenomenon during percutaneous coronary intervention. Improvement in coronary flow from no-reflow to postdrug state was evaluated. Patients who received adenosine (n = 21) were compared to ones who received the combination of adenosine and nitroprusside (n = 20) for treatment. Improvement of TIMI flow grades was higher in the group that received combined therapy (1.5 ± 1.0 vs. 0.8 ± 0.6; P < 0.05). Combination therapy of adenosine and nitroprusside is safe and provides better improvement in coronary flow compared to intracoronary adenosine alone in case of impaired flow during coronary interventions.

Original languageEnglish (US)
Pages (from-to)484-491
Number of pages8
JournalCatheterization and Cardiovascular Interventions
Volume61
Issue number4
DOIs
StatePublished - Apr 2004

Keywords

  • Adenosine
  • Coronary
  • Coronary blood flow
  • Percutaneous coronary intervention

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Cardiology and Cardiovascular Medicine

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