Abstract
Women with elevated mammographic percent density, defined as the ratio of fibroglandular tissue area to total breast area on a mammogram are at an increased risk of developing breast cancer. Ultrasound tomography (UST) is an imaging modality that can create tomographic sound speed images of a patients breast, which can then be used to measure breast density. These sound speed images are useful because physical tissue density is directly proportional to sound speed. The work presented here updates previous results that compared mammographic breast density measurements with UST breast density measurements within an ongoing study. The current analysis has been expanded to include 158 women with negative digital mammographic screens who then underwent a breast UST scan. Breast density was measured for both imaging modalities and preliminary analysis demonstrated strong and positive correlations (Spearman correlation coefficient rs = 0.703). Additional mammographic and UST related imaging characteristics were also analyzed and used to compare the behavior of both imaging modalities. Results suggest that UST can be used among women with negative mammographic screens as a quantitative marker of breast density that may avert shortcomings of mammography.
| Original language | English (US) |
|---|---|
| Title of host publication | Medical Imaging 2015 |
| Subtitle of host publication | Ultrasonic Imaging and Tomography |
| Publisher | SPIE |
| Volume | 9419 |
| ISBN (Electronic) | 9781628415094 |
| DOIs | |
| State | Published - 2015 |
| Event | Medical Imaging 2015: Ultrasonic Imaging and Tomography - Orlando, United States Duration: Feb 22 2015 → Feb 23 2015 |
Other
| Other | Medical Imaging 2015: Ultrasonic Imaging and Tomography |
|---|---|
| Country | United States |
| City | Orlando |
| Period | 2/22/15 → 2/23/15 |
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Keywords
- Breast cancer risk
- Breast density
- Mammography
- Sound speed
- Ultrasound tomography
ASJC Scopus subject areas
- Atomic and Molecular Physics, and Optics
- Electronic, Optical and Magnetic Materials
- Biomaterials
- Radiology Nuclear Medicine and imaging
Cite this
Comparison of breast density measurements made using ultrasound tomography and mammography. / Sak, Mark; Duric, Neb; Littrup, Peter; Bey-Knight, Lisa; Krycia, Mark; Sherman, Mark E.; Boyd, Norman; Gierach, Gretchen L.
Medical Imaging 2015: Ultrasonic Imaging and Tomography. Vol. 9419 SPIE, 2015. 94190R.Research output: Chapter in Book/Report/Conference proceeding › Conference contribution
}
TY - GEN
T1 - Comparison of breast density measurements made using ultrasound tomography and mammography
AU - Sak, Mark
AU - Duric, Neb
AU - Littrup, Peter
AU - Bey-Knight, Lisa
AU - Krycia, Mark
AU - Sherman, Mark E.
AU - Boyd, Norman
AU - Gierach, Gretchen L.
PY - 2015
Y1 - 2015
N2 - Women with elevated mammographic percent density, defined as the ratio of fibroglandular tissue area to total breast area on a mammogram are at an increased risk of developing breast cancer. Ultrasound tomography (UST) is an imaging modality that can create tomographic sound speed images of a patients breast, which can then be used to measure breast density. These sound speed images are useful because physical tissue density is directly proportional to sound speed. The work presented here updates previous results that compared mammographic breast density measurements with UST breast density measurements within an ongoing study. The current analysis has been expanded to include 158 women with negative digital mammographic screens who then underwent a breast UST scan. Breast density was measured for both imaging modalities and preliminary analysis demonstrated strong and positive correlations (Spearman correlation coefficient rs = 0.703). Additional mammographic and UST related imaging characteristics were also analyzed and used to compare the behavior of both imaging modalities. Results suggest that UST can be used among women with negative mammographic screens as a quantitative marker of breast density that may avert shortcomings of mammography.
AB - Women with elevated mammographic percent density, defined as the ratio of fibroglandular tissue area to total breast area on a mammogram are at an increased risk of developing breast cancer. Ultrasound tomography (UST) is an imaging modality that can create tomographic sound speed images of a patients breast, which can then be used to measure breast density. These sound speed images are useful because physical tissue density is directly proportional to sound speed. The work presented here updates previous results that compared mammographic breast density measurements with UST breast density measurements within an ongoing study. The current analysis has been expanded to include 158 women with negative digital mammographic screens who then underwent a breast UST scan. Breast density was measured for both imaging modalities and preliminary analysis demonstrated strong and positive correlations (Spearman correlation coefficient rs = 0.703). Additional mammographic and UST related imaging characteristics were also analyzed and used to compare the behavior of both imaging modalities. Results suggest that UST can be used among women with negative mammographic screens as a quantitative marker of breast density that may avert shortcomings of mammography.
KW - Breast cancer risk
KW - Breast density
KW - Mammography
KW - Sound speed
KW - Ultrasound tomography
UR - http://www.scopus.com/inward/record.url?scp=84943560815&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84943560815&partnerID=8YFLogxK
U2 - 10.1117/12.2082802
DO - 10.1117/12.2082802
M3 - Conference contribution
VL - 9419
BT - Medical Imaging 2015
PB - SPIE
ER -